Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: The iminophosphine ligands were prepared according to the method reported by Shirakawa and co-workers [70]. To 2-(diphenylphosphino)enzaldehyde(1) (200 mg, 0.689 mmol) 0.758 mmol (1.1 M equivalent) of the corresponding amine and 10 mL of freshly distilled toluene were added. The mixture was stirred under reflux (150?160 ¡ãC oil bath temperature) for 6 h.The solvent was removed in vacuo and the crude product was purified by bulb-to-bulb vacuum distillation (170 ¡ãC at 0.05 mm Hg,consistently used for all products) using a Kugel Rohr apparatus into which argon was continuously piped to prevent the ingress of oxygen. Since the iminophosphine products were unstable onsilica, no Rf-values are included for the iminophosphine ligands.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Traut-Johnstone, Telisha; Kanyanda, Stonard; Kriel, Frederik H.; Viljoen, Tanya; Kotze, P.D. Riekert; Van Zyl, Werner E.; Coates, Judy; Rees, D. Jasper G.; Meyer, Mervin; Hewer, Raymond; Williams, D. Bradley G.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 108 – 120;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Solution of di(1-naphthyl)phosphine oxide (0.1 g) in chloroform (5 mL) was refluxed in air for 2 h. Then the solvent was distilled under reduced pressure and residue was dried in vacuum. Di(1-naphthyl)phosphinic acid was prepared in near quantitative yield. White powder, mp 198-201 C, FT-IR (KBr): 3055, 3008, 2955, 2922, 2854, 2632, 2289, 1955, 1646, 1619, 1591, 1568, 1505, 1456, 1432, 1382, 1334, 1212, 1178, 1152, 1025, 995, 951, 833, 800, 773, 753, 680, 566, 526, 479. 1H NMR (CDCl3): 9.58 (br, 1H, OH), 8.48 (d, J 8.5 Hz, 2H, H8), 8.16 (dd, J 16.3 and 7.2 Hz, 2H, H2), 7.92 (d, J 8.4 Hz, 2H, H4), 7.79 (d, J 8.1 Hz, 2H, H5), 7.40-7.36 (m, 4H, H6,7), 7.29 (t, J 7.7 Hz, 2H, H3). 13C NMR (CDCl3): 133.5 (d, J 11 Hz, C9), 133.4 (d, J 11 Hz, C8), 133.3 (d, J 2 Hz, C7), 132.7 (d, J 11 Hz, C10), 128.9 (d, J 137 Hz, C1), 128.7 (C4), 127.1 (C5), 126.6 (d, J 5 Hz, C3), 126.1 (C6), 124.5 (d, J 15 Hz, C2). 31P NMR (CDCl3): 37.3 ppm. MS m/z calcd for C20H15O2P: MS (M+ 315)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kuimov, Vladimir A.; Matveeva, Elena A.; Khutsishvili, Spartak S.; Vakul’skaya, Tamara I.; Sinegovskaya, Lidiya M.; Malysheva, Svetlana F.; Gusarova, Nina K.; Trofimov, Boris A.; Tetrahedron; vol. 73; 32; (2017); p. 4723 – 4729;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

1608-26-0 N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine 15355, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Synthesis of the Intermediate Imines E8 Intermediate E8.1 Under argon in a sealed tube were added to a solution of (S)-N-(bis(4-methoxyphenyl)(phenyl)methyl)-4-(5-bromo-2-fluorophenyl)-4-(difluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (intermediate E7.1) (725 mg, 1.16 mmol) in toluene (15 ml) sodium tert-butoxide (334 mg, 3.48 mmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (73.8 mg, 174 mumol) and tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (60.0 mg, 58.0 mumol) and benzophenone imine (420 mg, 389 mul, 2.32 mmol), the tube was sealed under argon and the mixture was stirred at 105 C. for 4 h. The brown solution was extracted with ethyl acetate/water. The organic layer was washed with brine, dried over Na2SO4, filtered and evaporated to give a brown oil. The residue was chromatographed on 20 g silica gel with ethyl acetate 0-50% to give (S)-N-(bis(4-methoxyphenyl)(phenyl)methyl)-4-(difluoromethyl)-4-(5-(diphenylmethyleneamino)-2-fluorophenyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (525 mg, 723 mumol, 62.4% yield) as a yellow oil. MS (ISP): m/z=726.8 [M+H]+.

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; Woltering, Thomas; US2014/80819; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 (EX 6) (0129) IrCl3(THT)3 (300 mg, 0.63 mmol) was placed in a round-bottom flask, (0130) (239 mg, 0.63 mmol) and 20 ml decalin were subsequently added thereto to obtain the first mixture. The first mixture was heated under reflux and under a nitrogen atmosphere for a period of 6 hours. After the reaction was completed and the temperature was reduced to room temperature, decalin in the first mixture was removed by reduced pressure distillation. Thereafter, (0131) (122 mg, 0.63 mmol) and 15 ml dimethylformamide were sequentially added to the first mixture, from which decalin was removed, to obtain a second mixture. The second mixture was heated under reflux and under a nitrogen atmosphere for a second reaction period of 12 hours. After the reaction was completed and the temperature was cooled down to room temperature, dimethylformamide in the second mixture was removed by reduced pressure distillation to obtain a solid. The solid was washed using diethyl ether to obtain an intermediate product (400 mg, 80% yield)., 13991-08-7

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Liao, Jia-Ling; US8957208; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 0.32 g (1.61 mmol) of the compound [1], 0.47 g (1.61 mmol) of 2- (diphenylphosphino) benzaldehyde, 1.5 g (1.61 mmol) of Amberlyst 15 (0.11 g), 15 mL of toluene were added, and the mixture was allowed to react at 80 ¡ã C. for 8 hours. The reaction solution was filtered, and the filtrate was evaporated under reduced pressure to give 0.61 g (yield: 80percent) of the target compound (hereinafter referred to as the compound [3]) represented by the following formula [3].

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsui Chemicals; Ishii, Seiichi; Ichikawa, Shinichiro; Fujita, Otomo Toshinori; (49 pag.)JP2018/162230; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

In a 1000 ml reaction flask was charged with 99.5 g (0.46 mol)Diphenylmethoxyphosphine (purity ? 99.5%) and 109.7 g(0.64 mol) of m-methoxybenzyl chloride (content of ? 99.2%), heated to 58 C with stirring, and incubated at this temperature for 8 hours, The end of Paul to cool to 15 C, directly into the next step reaction., 4020-99-9

As the paragraph descriping shows that 4020-99-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Chengche Pharmaceutical & Chemical Co., Ltd; Xia, Qiujing; (6 pag.)CN105541565; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under inert gas protection conditions,To a flask equipped with a stirring magnet, 344 mg of Fe2S2(CO)6 (1 mmol) and 30 mL of tetrahydrofuran solvent were added.A dark red solution was obtained, and the resulting solution was cooled to -78 ¡ã C with a liquid nitrogen bath.2.1 mL of lithium triethylborohydride (1M in THF) solution was slowly added under stirring.After reacting for 15 min, 0.2 mL of trifluoroacetic acid (2.5 mmol) was added and the reaction was continued for 15 min.Add 348 mg of P(C6H4-4-F)3 (1.1 mmol), stir at room temperature for 3 h before adding788 mg of I-4-C6H4N(CH2Cl)2 (2.5 mmol) and 0.3 mL of triethylamine were stirred at room temperature for 12 h.The solvent of tetrahydrofuran was removed by rotary distillation, and the residue was extracted with dichloromethane, and then subjected to thin-layer chromatography using a solvent of dichloromethane/petroleum ether ratio of 1:5 to collect a main color band to obtain a model 2 .

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan University of Science and Engineering; Li Yulong; He Jiao; Wu Yu; Xie Ying; Jiang Jin; Sun Yanchun; Wang Zheng; Zou Like; Xie Bin; Gao Fan; Mu Chao; (11 pag.)CN109232665; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, [Pd(allyl)(brettphos)]OTf was synthesized according to the literature.[4] A dry Schlenk flask equipped with a Teflon-coated magnetic stirring bar was charged with [(allyl)PdCl]2 (183 mg, 0.5 mmol) followed by AgOTf (257 mg, 1.0 mmol). The flask was fitted with a rubber septum, evacuated, and backfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated two additional times. Solvent (10 mLof THF) was added, and the reaction mixture was stirred at room temperature for 30min while protected from light. A second dry Schlenk flask was equipped with a magnetic stirring bar, fitted with a Schlenk frit, and charged with BrettPhos (537 mg,1.0 mmol). The flask was fitted with a rubber septum, and it was evacuated andbackfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated twoadditional times. The solution from the first Schlenk flask was transferred through amillipore filter (to remove AgCl) into the second Schlenk flask containing the ligand,rinsing with 5 mL of additional solvent (THF). This mixture was stirred at roomtemperature for 2 h. Hexanes (450 mL) was then added to the mixture to fullyprecipitate the product. The solid materials were then collected by suction filtration,washed with additional hexanes, and dried in vacuo to give 734 mg (86%) of the titlecompound as a yellow solid.

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Wentong; Kuang, Yi; Wang, Zhifan; Zhu, Jin; Wang, Yuanhua; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 542 – 550;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

EXAMPLE 8 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs,1H).

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate