With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.
6737-42-4, 4-[Isopropyl-(7-isopropyl-3,3,6-trimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid methyl ester (Compound 67) Following general procedure O and using 7-isopropyl-5-[isopropyl-(4-trifluoromethanesulfonyloxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 63, 0.052 g, 0. 107 mmol), triethyl amine (0.4 mL, 0.28 mmol), palladium(II)acetate (0.030 g, 0.13 mmol) and 1,3-bis(diphenylphosphino)propane (0.041 g, 0.1 mmol) in a mixture of 3 mL of methanol, 2 mL of dimethylsulfoxide and 1 mL of 1,2-dichloroethane, the title compound (0.037 g, 84%) was obtained as a brown oil. 1 H NMR (300 MHz, CDCl3): delta 7.81 (d, 2H, J=9.2 Hz), 6.59 (s, 1H), 6.40 (d, 2H, J=9.2 Hz), 4.32 (heptet, 1H, J=6.6 Hz), 4.24 (s, 2H), 3.83 (s, 3H), 3.19 (heptet, 1H, J=7.0 Hz), 2.00 (s, 3H), 1.36-1.26 (m, 15H), 0.98 (d, 3H, J=6.6 Hz).
The synthetic route of 6737-42-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Allergan Sales, Inc.; US6093838; (2000); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate