With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
A mixture of 0.23 g (0.6 mmol) of iodo aminoester (S)-2-(t-butyloxycarbonylamino)allyl-4-iodobutanoate (III’) and 0.42 g (1.2 mmol) of [tri-(4- methoxyphenyl)]phosphine in 0.5 mL of dry THF was stirred under argon at 80C. After three hours, 3 mL of toluene followed by 30 mL of diethyl ether were added to the mixture at room temperature. The white precipitate was washed with 2 x 25 mL of diethyl ether and purified by chromatography with a mixture of acetone / petroleum ether (3 : 7) as eluent. The phosphonium salt (II’c) was isolated in 70% yield. Pale yellow solid 31P NMR (121 MHz, CDCl3) : 5(ppm) = +21 (s).
The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; JUGE, Sylvain; BAYARDON, Jerome; REMOND, Emmanuelle; ONDEL-EYMIN, Marie-Joelle; WO2013/30193; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate