With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0
Compound 110: Os3(C0)10(CNh (20 mg, 0.022 mmol) was dissolved in dichloromethane (3 ml).HS(CH2)2NCH2(CsNHs)2 (1 eq) was then added and the reaction mixture was stirred at roomtemperature overnight. The solvent was removed and the crude material was purified by columnchromatography to obtain product precursor (110a) in 88% yield. Compound (110a) was thenfurther modified as summarized in Figure 1 to yield compound (110).
The synthetic route of 63995-70-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MELVILLE, Chris R.; INBAR FESKE, Miriam; HERSCHLEB, Jill Lynden; JOHNS, Adam Matthew; GREENMAN, Kevin Lloyd; PARTYKA, David; ZALATAN, David; TOSTE, Dean F.; WO2014/14852; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate