With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.
25 mL of Schlenk tube, and 2-diphenylphosphino-2 ‘- (N, N-dimethylamino) biphenyl was added to a solution of 76.3 mg (0.2 mmol), (1,5-cyclooctadiene) chloride2.5 mg of rhodium (I) dimer (2.5% of moles of raw material), and 32 mg of lithium tert-butoxide (0.4 mmol), argon was replaced three times, and 1 mL of 1,4-dioxane and 47.1 mg (0.3 mmol) of bromobenzene were added under argon. 120 C for 36 hours, cooled to room temperature and evaporated under reduced pressure. The solvent was separated on a 200-300 mesh silica gel column. The petroleum ether: Ester = 100: 1 and dried in vacuo to give 56.9 mg of product as a white solid in 62% yield,
240417-00-9 2-Diphenylphosphino-2’-(N,N-dimethylamino)biphenyl 2734939, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate