Day: August 27, 2020

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 (0.2 mmol) and P(3-C6H4Cl)3 (0.2 mmol) in MeCN (15 mL) was added a solution of Me3NO¡¤2H2O (0.2 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h and then the solvent was reduced on a rotary evaporator and the residue was subjected to TLC separationusing CH2Cl2/petroleum ether = 1 : 3 (v/v) as eluent. The main red band gave 0.110 g (71percent) of 2 as a red solid.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xu-Feng; Journal of Coordination Chemistry; vol. 69; 17; (2016); p. 2620 – 2629;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

1,1′-Bis(diphenylphosphino)ferrocene (dppf) (0.554 g, 1.0 mmol) was added to a solution of gold(I) cyanide (0.223 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture at room temperature.The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h. Slowly, the colour of the solution changed from light yellowish orange to dark yellowish orange. The resulting solution was evaporated to dryness to give a dark yellowish orange solid which were separated and washed with hexane and dried. Yield: (0.500 g, 50 percent). Anal. Calc. for C36H28N2P2Au2Fe: C, 43.20; H,2.80; N, 2.80. Found: C, 43.32; H, 2.85; N, 2.91. IR (cm-1, KBr): nu = 3430, 3022, 2929, 2147(CN), 1956, 1650, 1580, 1479, 1428, 1308, 1164, 1157, 1091, 1086, 1022, 890, 820, 740, 691, 630, 494. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K): 8.10-7.30 (m, 40H, Ph), 4.35 (s, 8H,C5H4), 4.10 (s, 8H, C5H4). 31P{1H}: delta 31.4 (s) (Sharp). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 275 (18,904), 450 (30,337). ESI-MS (m/z): 1000.8 (M+).

The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an anhydrous, argon-filled glovebox, a 4 ml. vial was charged with TpRh(COD) (12.7 mg, 0.0300 mmol, 1 .00 equiv) and dppf (16.9 mg, 0.0300 mmol, 1 .00 equiv). After adding 1.0 ml. of MeCN to the reaction mixture, the vial was sealed with a Teflon cap and moved out of the glovebox to a preheated metal heating block at 1 10 ¡ãC. After 1 hour, the resulting mixture was cooled to 23 ¡ãC. Orange crystals precipitated from the solution within 1 hour. The vial was then placed in a 4 ¡ãC fridge for 12 hours. After warming the solution to 23 ¡ãC, 18.8 mg (72percent) of crystals were obtained by careful filtration. The quality of the crystals was suitable for X-ray crystallographic analysis. The compound has a limited lifetime in solution. In solid state, TpRh(dppf) can be oxidized by air.NMR Spectroscopy:1H NMR (500 MHz, CD2CI2, 23 ¡ãC, delta): 7.77 – 7.58 (br. m, 10H), 7.23 – 6.93 (br. m, 16H), 6.24 (br. s, 1 H), 5.74 (br. s, 1 H), 5.42 (br. s, 1 H), 4.13 – 3.89 (br. m, 9H).13C NMR (125 MHz, CD2CI2, 23 ¡ãC, delta): 141 .3, (d, J = 153.5 Hz), 136.5 – 136.0 (br, m), 134.8 (br, s), 134.1 , 133.3 – 132.4 (br, d), 128.5, 126.7, 103.2, 78.8 – 78.5 (br, m), 75.1 – 73.9 (br, m), 71 .4.31P NMR (202 MHz, CD2CI2, 23 ¡ãC, delta): 46.5 (d, J = 183 Hz), 44.7 (d, J = 183 Hz).11B NMR (128 MHz, CD2CI2, 23 ¡ãC, delta): -1.28 (br. s).HRMS-FIA (m/z) calc’d for C43H38BFeN6P2Rh [M+H]+, 871 .1214, found: 871 .1204.

12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; STUDIENGESELLSCHAFT KOHLE MBH; RITTER, Tobias; YE, Fei; (45 pag.)WO2018/210631; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

(2) A suspension of the compound obtained in (1) (89.27 g), ethyl 1H-pyrazole-4-carboxylate (45.16 g), tripotassium phosphate (93.3 g), 2-di-t-butylphosphino-2′,4′,6′-triisopropyl biphenyl (9.33 g) and tris(dibenzylideneacetone)dipalladium(0) (6.7 g) in t-butyl alcohol (900 mL) was stirred for 2 hours at 90 C. under nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure, and the residue was added with chloroform and water. The organic layer was separated, and the aqueous layer was extracted with chloroform. The NH-silica gel (100 mL) and sodium sulfate (100 g) were added to the organic layer, and insoluble materials were removed by filtration. The filtrate was concentrated under reduced pressure, and the residue was added with methanol. The resulting crystals were collected by filtration to yield ethyl 1-[7-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylate (78.94 g, 66% yield) as colorless crystals. MS (APCI) m/z: 409 [M+H]+.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei; US2015/239889; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

101.4 mg (0.3 mmol) was added to the reaction kettle.2-diphenylphosphine-biphenyl (compound I-2),141 muL of tert-butyl acrylate (Compound II-2), 9.3 mg of cymene dichloride dimer, 15.8 mg of N-Boc-glycine, 5.3 mg of tris(4-methoxyphenyl)phosphine,58.8 mg of potassium acetate and 1.5 mL of n-hexane,After stirring and mixing uniformly, argon gas is introduced into the reaction system to control the reaction in an argon atmosphere.The temperature was reacted at 120 C for 24 h and then cooled to room temperature.Separation of diatomaceous earth by vacuum filtration and column chromatography101 mg of the desired product in a yield of 72%.

As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Patent; Hubei University; Liu Yuejin; Wang Liangneng; Li Jiawei; Zeng Minghua; Li Ming; Tang Panting; (17 pag.)CN109851635; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

25 mL of Schlenk tube, and 2-diphenylphosphino-2 ‘- (N, N-dimethylamino) biphenyl was added to a solution of 76.3 mg (0.2 mmol), (1,5-cyclooctadiene) chloride2.5 mg of rhodium (I) dimer (2.5% of moles of raw material), and 32 mg of lithium tert-butoxide (0.4 mmol), argon was replaced three times, and 1 mL of 1,4-dioxane and 47.1 mg (0.3 mmol) of bromobenzene were added under argon. 120 C for 36 hours, cooled to room temperature and evaporated under reduced pressure. The solvent was separated on a 200-300 mesh silica gel column. The petroleum ether: Ester = 100: 1 and dried in vacuo to give 56.9 mg of product as a white solid in 62% yield,

240417-00-9 2-Diphenylphosphino-2’-(N,N-dimethylamino)biphenyl 2734939, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 317 Production of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}amino)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide A mixture of N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (330 mg, 1.0 mmol), N-(3-aminophenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide (280 mg, 1.2 mmol), tris(dibenzylideneacetone)dipalladium (0) (46 mg, 0.050 mmol), 2-dicyclohexylphosphino-2′,4′,6′-tri-isopropyl-1,1′-biphenyl (48 mg, 0.10 mmol), potassium tert-butoxide (170 mg, 1.5 mmol) and tert-butanol was heated under reflux for 2 days. Ethyl acetate/tetrahydrofuran and saturated aqueous sodium hydrogencarbonate solution were added to the mixture, the aqueous layer was extracted with ethyl acetate/tetrahydrofuran (*4). Combined organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=30/70?100/0) to give the title compound (37 mg, 9%) as a brown solid. 1H-NMR (DMSO-d6, 300 MHz) delta 0.74-0.88 (4H, m), 1.86-1.98 (1H, m), 2.22 (3H, s), 4.01 (3H, s), 6.85 (1H, s), 6.89 (1H, d, J=9.6 Hz), 7.24-7.36 (2H, m), 7.45-7.53 (1H, m), 7.75 (1H, d, J=9.6 Hz), 8.00 (1H, s), 8.21 (1H, s), 9.37 (1H, s), 10.15 (1H, s), 10.93 (1H, s).

As the paragraph descriping shows that 564483-18-7 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-1-benzoic acid methyl ester To a solution of trifluoro-methanesulfonic acid 4-[1-benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-phenyl ester (10.0 g, 19.8 mmol) in a Parr pressure bottle in MeOH (69 mL) were added DMSO (62 mL) and triethylamine (21.8 mL, 157 mmol). To the reaction mixture were added palladium acetate (2.2 g, 9.1 mmol) and 1,3-bis(diphenylphosphino)propane(3.75 g, 9.1 mmol). The mixture was shaken under 40 psi of CO at 70 C. for 4 hours. The reaction mixture was cooled to room temperature and was diluted with diethyl ether (600 mL). The ether layer was washed with water (5*60 mL), dried (MgSO4) and concentrated. The crude residue was purified by flash chromatography with hexanes/EtOAc (1:1) to afford 6.9 g (85% yield) of 4-[1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-yl]-benzoic acid methyl ester. 1H-NMR (400 MHz, CDCl3) delta 7.91 (d, 2H), 7.32 (d, 2H), 7.28-7.16 (comp, 6H),), 6.82 (d,, 1H), 6.79 (s, 1 H), 6.68 (dd, 1H), 3.86 (s, 3H), 3.74 (s, 3H), 3.38 (s, 2H), 2.47-2.44 (comp, 8H); MS (M+1) 416.2.

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Liras, Spiros; US2002/13321; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate