With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.829-85-6,Diphenylphosphine,as a common compound, the synthetic route is as follows.
1.86 g (10 mmol) of diphenyl phosphane and 10 ml of tetrahydrofuran were introduced into a four-neck flask of 100 ml in capacity that had been fully replaced with nitrogen. Into this mixture, 7.63 g of 1.4 mol/kg isopropyl magnesium chloride/lithium chloride-THF solution was dripped over 30 minutes at a constant temperature between 0 C. and 2 C. After the entire solution had been dripped, the mixture was agitated for 4 hours at a temperature of 0 C., to manufacture a diphenyl phosphanyl magnesium chloride/lithium chloride complex. Into this complex, a solution prepared from 0.99 g (7.8 mmol) of benzoyl chloride and 5 ml of tetrahydrofuran was dripped over 1 hour at a constant temperature of 0 C. After the entire solution had been dripped, the mixture was agitated for 8 hours at a temperature of 0 C. Thereafter, 8.5 g of toluene was added to the reaction liquid, after which 10 ml of 5% aqueous sulfuric acid solution was added to the reaction liquid to separate out the organic layer which was then washed with 10 g of water, 10 g of 5% sodium bicarbonate water, and 10 g of water, in this order. The solvent was distilled away from the obtained organic layer under reduced pressure and the residue was dissolved in 5 ml of methanol at 50 C., after which the solution was cooled to 0 C., and thus 1.83 g of benzyl diphenyl phosphine (purity: 98%) was obtained as white crystal. The yield was 85%.
As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.
Reference£º
Patent; HOKKO CHEMICAL INDUSTRY CO., LTD.; SUZUKI, Kenta; KUMAMOTO, Nobumichi; ITO, Nobuhiro; HATAE, Shinji; SUZUKI, Hiroyuki; US2019/248815; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate