With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.
At room temperature under argon, a solution of sec-BuLi (22 mL, 1.3 mol dm-3, 0.029 mol, 3 eq) in hexane is added dropwise to a stirred solution of diphenyl ether (1.6 g, 9.5.x.10-3 mol, 1 eq) and tetramethylethylenediamine (TMEDA, 3.4 g, 0.029 mol, 3 eq) in dry degassed diethyl ether and stirred for 16 hours. A solution of chlorodiphenylphosphine (5.2 mL, 0.029 mol, 3 eq) in hexane is then added dropwise, and the reaction mixture stirred for a further 16 hours. The solvent is removed under reduced pressure, and the resulting oil dissolved in CH2Cl2, washed with water and dried with MgSO4. The solvent is removed under reduced pressure, and the resulting yellow oil is recrystallized from ethanol to yield 2,2′-bis(diphenylphosphino)diphenyl ether.
1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Patent; White, Daniel F.; US2011/124904; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate