Day: August 26, 2020

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 296.4 mg of tricyclohexylphosphorus oxide and 188.5 mg of DyCl3 ¡¤6H2O was added to a beaker, 15 mL of ethanol and 5 mL of water were added, and the mixture was stirred at room temperature for 4 hours. Then, the mixed solution was allowed to stand at room temperature for 3 days to obtain colorless rectangular crystals. The resulting crystals were washed with iced ethanol to purify the resulting product. The calculated yield based on the metal Dy was 52%.

The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nankai University; Cheng Peng; Wang Yuxia; Shi Wei; (8 pag.)CN107556341; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Potassium tetrachloropalladate(II) was prepared by the procedure described in [26]. Potassium chloride, 2 equiv, was added to a solution of palladium(II) chloride in 25 mL of distilled water with stirring over a period of 30 min. The mixture was cooled with ice, and yellowish-brown crystals of potassium tetrachloropalladate(II) separated in a few minutes. The crystals were collected by filtration and recrystallized from water containing a few drops of aqueous HCl. The complexes were prepared by adding 2 equiv of the corresponding phosphine in 15 mL of acetonitrile to a solution of 0.326 g of K2[PdCl4] in15 mL of water, followed by stirring. After 30 min, a solution of 2 equiv of N,N-dimethylthiourea in 15 mL of methanol was added, and the mixture was stirred for one hour. The resulting yellow or red solution was filtered, and the filtrate was kept at room temperature for three to five days. Slow evaporation of the acetonitrile-methanol solution afforded solid complex 1-3. The overall reaction is shown in Scheme 1.

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aziz; Sirajuddin; Munir; Tirmizi; Nadeem; Tahir; Sajjad; Russian Journal of General Chemistry; vol. 88; 3; (2018); p. 551 – 559;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

A solution of tyramine (239 mg, 1.74 mmol) in hot EtOH (8 mL) was added dropwise to a solution of 2-(diphenylphosphino)benzaldehyde (505 mg, 1.69 mmol) in hot EtOH (8 mL). The mixture was left stirring at 45 C for 2 h (31P NMR monitoring). Solvent was removed in vacuum to afford 1 in 84percent yield (603 mg,1.47 mmol) as a pale yellow powder. 31P{1H} NMR (121.25 MHz,CDCl3, d (ppm)): 14.1 (s, PIII). 1H NMR (300 MHz, CDCl3, d(ppm)): 2.73 (t, JHH = 7.55 Hz, 2H, CH2Cx4), 3.75 (t, JHH = 7.55 Hz,2H, NCH2), 6.72 (d, JHH = 8.25 Hz, 2H, Cx2H), 6.97 (d, JHH = 8.25 Hz,2H, Cx2H), 6.9?7.0 (m, 1H, Cy3H), 7.20?7.75 (m, 12H, Harom), 7.97(br s, 1H, OH), 8.04 (dd, JHH = 6.9 Hz, JHH = 3.9 Hz, 1H, Cy8H), 8.97(d, JHP = 4.8 Hz, 1H, CHN). 13C{1H} NMR (75.5 MHz, CDCl3, d(ppm)): 36.42 (s, CH2Cx4), 62.98 (s, CH2N), 115.61 (s, Cx2), 127.79(d, JCP = 4.0 Hz, Cy5), 128.79 (d, JCP = 7.2 Hz, Cm), 128.97 (s, Cx4),129.09 (s, Cp), 129.23 (s, Cy6), 129.84 (s, Cx3), 130.64 (s, Cy4),133.32 (s, Cy3), 134.13 (d, JCP = 20.4 Hz, Co), 136.19 (d, JCP = 9.2 Hz,Ci), 137.73 (d, JCP = 18.6 Hz, Cy1), 138.95 (d, JCP = 17.2 Hz, Cy2),155.02 (s, Cx1), 161.31 (d, JCP = 23 Hz, CHN). MS (DCI/NH3, CHCl3,positive) m/z: 410.4 [M+1].

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Tristany, Mar; Laurent, Re?gis; Dib, Hanna; Gonsalvi, Luca; Peruzzini, Maurizio; Majoral, Jean-Pierre; Caminade, Anne-Marie; Inorganica Chimica Acta; vol. 409; PART A; (2014); p. 121 – 126;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The crude solid was treated with 1.31 mL of thionyl chloride and heated on a steam bath for 1 hour. After cooling to room temperature, the crude mixture was taken up in water and extracted with ether. The ether was washed with water and dried(MgSO4), and concentrated to give an oily residue which was purified by silica gel chromatography (25% methylene chloride/75% hexane) to give 2.70 grams (85.6%) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride as a solid. 2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150 C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography (10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the above-titled compound. MP 109-111 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US5935945; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61.0mg mesityl -Cu and 3ml of toluene were added to 100.0mg(0.33 mmol) of 7-BTpCa and 149.3mg (0.33 mmol) of dppb in a glove box. It formsa yellow solution. It was filtered and was coated with a layer of hexane. itforms yellow crystals. under UV (356nm), these emit a strong green and thesolution in the same way emits a strong green. Yield: 83%.

As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19845-69-3,1,6-Bis(diphenylphosphino)hexane,as a common compound, the synthetic route is as follows.

General procedure: A mixture of the dimeric complex [Pd(mu-Cl)(Cl)(NHC)]2(0.10 mmol) and the appropriate diphosphine ligand (0.10 mmol) was dissolved in CH2Cl2 (5.0 mL) and stirred at ambient temperature overnight. The reaction mixture was filtered over Celite, the solvent was reduced under vacuum to about 1.0 mL and the yellow precipitate formed by careful addition of n-hexane (c.a. 10 mL). The yellow solid was then filtered off, washed with n-hexane, and dried under vacuum.

The synthetic route of 19845-69-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Jin; Li, Pinhua; Zhang, Yicheng; Wang, Lei; Journal of Organometallic Chemistry; vol. 766; (2014); p. 73 – 78;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.829-85-6,Diphenylphosphine,as a common compound, the synthetic route is as follows.

1.86 g (10 mmol) of diphenyl phosphane and 10 ml of tetrahydrofuran were introduced into a four-neck flask of 100 ml in capacity that had been fully replaced with nitrogen. Into this mixture, 7.63 g of 1.4 mol/kg isopropyl magnesium chloride/lithium chloride-THF solution was dripped over 30 minutes at a constant temperature between 0 C. and 2 C. After the entire solution had been dripped, the mixture was agitated for 4 hours at a temperature of 0 C., to manufacture a diphenyl phosphanyl magnesium chloride/lithium chloride complex. Into this complex, a solution prepared from 0.99 g (7.8 mmol) of benzoyl chloride and 5 ml of tetrahydrofuran was dripped over 1 hour at a constant temperature of 0 C. After the entire solution had been dripped, the mixture was agitated for 8 hours at a temperature of 0 C. Thereafter, 8.5 g of toluene was added to the reaction liquid, after which 10 ml of 5% aqueous sulfuric acid solution was added to the reaction liquid to separate out the organic layer which was then washed with 10 g of water, 10 g of 5% sodium bicarbonate water, and 10 g of water, in this order. The solvent was distilled away from the obtained organic layer under reduced pressure and the residue was dissolved in 5 ml of methanol at 50 C., after which the solution was cooled to 0 C., and thus 1.83 g of benzyl diphenyl phosphine (purity: 98%) was obtained as white crystal. The yield was 85%.

As the paragraph descriping shows that 829-85-6 is playing an increasingly important role.

Reference£º
Patent; HOKKO CHEMICAL INDUSTRY CO., LTD.; SUZUKI, Kenta; KUMAMOTO, Nobumichi; ITO, Nobuhiro; HATAE, Shinji; SUZUKI, Hiroyuki; US2019/248815; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5518-52-5, Tri(furan-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 1-[3-(2,4-Difluoro-benzyl)-phenyl]-ethanone L2-A To an oven dried three-necked 100 mL round bottom flask fitted with argon inlet, temperature probe and stir bar was added zinc powder (793 mg, 12.2 mmol), 1,2-dibromoethane (21 muL, 0.24 mmol), and THF (2 mL). The mixture was brought to reflux two times using a heat gun then cooled to 0 C. at which time alpha-bromo-2,4-difluorotoluene (781 muL, 6.10 mL) in THF (3 mL) was added slowly keeping the temperature <3 C. To another 3-necked round bottom flask fitted as above was added bis(dibenzylideneacetone)palladium (Pd(dba)2, 234 mg, 0.41 mmol), tris(2-furyl)phosphine (tfp, 189 mg, 0.81 mmol), and THF (5 mL). The mixture was stirred 10 minutes at room temperature then cooled to 0 C. at which time 3'-iodoacetophenone (562 muL, 4.06 mmol) in THF (1 mL) was added. The flask was flushed with argon and the zinc mixture was pipetted in. After stirring 5 minutes at 0 C., the reaction was left to stir over night at room temperature. The next morning the reaction was quenched with sat. NH4Cl solution and extracted three times with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated to a brown oil. The crude product was chromatographed on silica gel using 5% EtOAc/hexane as elutant. Pure product fractions were combined and concentrated to afford L2-A as a yellow oil. Rf=0.22 (5% EtOAc/hexane). 1H NMR (400 MHz, CDCl3) delta7.81 (m, 2H), 7.39 (m, 2H), 7.11 (m, 1H), 6.81 (m, 2H), 4.02 (s, 2H), 2.56 (s, 3H). The synthetic route of 5518-52-5 has been constantly updated, and we look forward to future research findings. Reference£º
Patent; Merck & Co., Inc.; Tularik Inc.; US6380249; (2002); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

At room temperature under argon, a solution of sec-BuLi (22 mL, 1.3 mol dm-3, 0.029 mol, 3 eq) in hexane is added dropwise to a stirred solution of diphenyl ether (1.6 g, 9.5.x.10-3 mol, 1 eq) and tetramethylethylenediamine (TMEDA, 3.4 g, 0.029 mol, 3 eq) in dry degassed diethyl ether and stirred for 16 hours. A solution of chlorodiphenylphosphine (5.2 mL, 0.029 mol, 3 eq) in hexane is then added dropwise, and the reaction mixture stirred for a further 16 hours. The solvent is removed under reduced pressure, and the resulting oil dissolved in CH2Cl2, washed with water and dried with MgSO4. The solvent is removed under reduced pressure, and the resulting yellow oil is recrystallized from ethanol to yield 2,2′-bis(diphenylphosphino)diphenyl ether.

1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; White, Daniel F.; US2011/124904; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate