With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
To a CH2Cl2 solution (20 mL) of (1) (50 mg, 0.041 mmol) and P(4-FC6H4)3 (13 mg, 0.041 mmol), was added dropwise a solution of Me3NO (3 mg, 0.041 mmol) in the same solvent (10 mL). The mixture was then heated to reflux for 8 h. The solvent was removed by rotary evaporation and the residue chromatographed by TLC on silica gel. Elution with cyclohexane/CH2Cl2 (7:3, v/v) gave three bands. The major band afforded compound [Os3(CO)9(mu-dppm)- {P(4-FC6H4)3}] (2) (30 mg, 49percent) as yellow crystals after recrystallization from hexane/CH2Cl2 at 4 ¡ãC. The contents of other bands were too little for characterization. Spectroscopic data for (2): Anal. (percent) Calcd for C52H34F3O9Os3P3: C 40.99; H2.25. Found: C 41.33; H 2.32. IR (cm-1) (nuCO, CH2Cl2): 2063 w, 1999 s, 1978 vs, 1961 sh, 1935 m. 1H NMR (CDCl3, 25 C): delta 7.44 (m, 6H), 7.34 (m, 20H), 7.09 (m, 6H), 4.93 (t, J = 10 Hz, 2H). 31P{1H} NMR (CDCl3,25 C): delta ?3.6 (s, 2P), ?27.6 (s, 1P). FAB MS: m/z1523 [M+].
18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Article; Miah, Abdur R.; Rajbangshi, Subas; Hossain, Kamal; Siddiquee, Tasneem A.; Kabir, Shariff E.; Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical; vol. 54A; 5; (2015); p. 581 – 587;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate