With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.
A mixture of [Cu(CH3CN)4](ClO4) (0.0654g, 0.2mmol), dppbe (0.0893g, 0.2mmol) and Bphen (0.0665g, 0.2mmol) were dissolved in a mixture of CH2Cl2 (5ml) and CH3OH (5ml), then stirred for 6h. The insoluble residues were removed by filtration and the filtrate was evaporated slowly at room temperature for a week to yield a yellow crystalline product. Yield: 74%. Anal. Calc. for C56H48ClCuN2O6P2: C, 66.81; H, 4.77; N, 2.78. Found: C, 67.71; H, 4.75; N, 2.86%. IR (cm-1): 3446s, 2377w, 2345w, 1622m, 1553w, 1515w, 1481w, 1436m, 1121s, 1091vs, 866w, 742m, 697s, 668w, 623m, 531m, 496w. 1H NMR (600MHz, CDCl3, 298K) delta, ppm: 7.2-7.8 (m, overlap with the solvent peak signal, Bphen-aromatic ring, dppbe-aromatic ring), 8.8 (d, Bphen-aromatic ring).
The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Yan-Ru; Yu, Xiao; Lin, Sen; Jin, Qiong-Hua; Yang, Yu-Ping; Liu, Min; Li, Zhong-Feng; Zhang, Cun-Lin; Xin, Xiu-Lan; Polyhedron; vol. 138; (2017); p. 46 – 56;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate