With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.
To a colourless solution of [(C6F5)2Pt(mu-PPh2)2Pt(NCMe)2] (0.150g, 0.127mmol) in acetone (5mL) was added dppf (0.071g, 0.127mmol). The resulting yellow solution was stirred at room temperature for 1h and then evaporated to 2mL. Complex 1 crystallized as a yellow solid, which was filtered, washed with Et2O (2¡Á2mL) and vacuum-dried. Yield: 0.178g, 85percent. Anal. Found (Calc. for C70H48F10FeP4Pt2): C, 51.07 (50.99); H, 3.08 (2.93). IR (Nujol, cm?1): 1161 (vs), 821 (s) dppf; 952 (vs), 781(vs) (Fermi res., C6F5), 772 (vs) (X-sensitive C6F5). 1H NMR (thf-d8, 295K, 400MHz): delta 4.10 (s, CbetaH, 4H), 4.41 (s, CgammaH, 4H), from 6.5 to 8.5 (m, Ph, 40H). 19F NMR (thf-d8, 300K, 376.5MHz): delta ?116.7 (4 o-F, 3JF,Pt(1)=325Hz), ?168.8 (m, 4 m-F), ?169.6 (t, 2 p-F, 3JF,F=20Hz); 31P{1H} NMR (thf-d8, 295K, 162MHz): delta 12.0 (m, 2JP(3),P(1)=2JP(4),P(2)=239Hz, 2JP(3),P(4)=55Hz, 2JP(3),P(2)=2JP(4),P(1)=14Hz, 1JP,Pt=2210Hz, P3/4), ?98.6 (m, 2JP(1),P(3)=2JP(2),P(4)=239Hz, 2JP(1),P(2)=111Hz, 2JP(1),P(4)=2JP(2),P(3)=14Hz, 1JP,Pt(1)=1802Hz, 1JP,Pt(2)=1745Hz, P1/2) ppm. 195Pt{1H} NMR (thf-d8, 295K, 86MHz): delta ?3761 (m, Pt1), ?4235 (m, Pt2), ppm.
As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.
Reference£º
Article; Giardina-Papa, Daniela; Ara, Irene; Ibanez, Susana; Mastrorilli, Piero; Gallo, Vito; Fornies, Juan; Polyhedron; vol. 120; (2016); p. 44 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate