With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.
trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OEt)), trans-C777: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OEt) (0.607 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from toluene/pentane at -35 C affording trans-C777 (1.48 g, 67.2%, >95% purity). ?H NMR (400 MHz, CD2C12, ppm): oe18.39 (d, J= 11.2 Hz, 1H), 7.34 – 7.26 (m, 2H), 7.24 – 7.14 (m, 8H), 7.03 – 6.95 (m, 1H), 6.89 (s, 2H), 6.79 (s, 2H), 4.08 – 3.88 (m, 4H), 3.36 (pseudo pentet, J= 6.9 Hz, 2H), 2.56 (s, 6H), 2.36 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.11 (s, 3H), 1.07 (t, J= 6.9 Hz, 3H), 1.03 (s, 3H). 3?PNIVIR(161.8 IVIHz, CD2C12, ppm): oe 129.8 (s).
719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate