With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.
Add cyclohexylcarboxylic acid (136 mg, 1 mmol), 4-dimethylaminopyridine (DMAP, 18.3 mg, 0.15 mmol), dicyclohexylcarbodiimide (DCC, 340 mg, 1.65 mmol), and hydrogen peroxide to the reaction flask. (57 muL 1.9 mmol) and dichloromethane (5 mL), stirred at room temperature for 2 hours, filtered, and distilled off the solvent in the filtrate to obtain a concentrate;To the concentrate were added copper bromide (17.8 mg, 0.08 mmol), 6,6′-dimethyl-2,2′-bipyridine (14.7 mg, 0.08 mmol), and ethylene glycol dimethyl ether (1 mL). And diphenylphosphine (50.5 mg, 0.25 mmol), stirred at 60 oC, TLC monitoring until the end of the reaction;The crude product obtained after the reaction was separated by column chromatography (petroleum ether: acetone = 4: 1) to obtain the target product (yield 75%).
The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate