Day: August 21, 2020

224311-51-7, 2-(Di-tert-Butylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50 ml of degassed, anhydrous methanol were heated to reflux temperature, and 2.36 g (7.9 mmol) of 2-(di-tert-butylphosphino)biphenyl were added slowly to the methanol until the phosphine compound was completely dissolved. Subsequently, 0.59 g (2.6 mmol) of copper(II) bromide was added to the solution in portions. After the copper bromide had been added, the solution was heated to reflux temperature for a further 15 min, and then the solution was cooled. After the solution had been cooled, a solid precipitated out and was filtered off, and was washed with a little ethanol and diethyl ether and subsequently dried. 0.93 g (1.1 mmol) of the abovementioned compound was obtained. The yield was 80percent of theory.

224311-51-7 2-(Di-tert-Butylphosphino)biphenyl 2734215, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Scholz, Ulrich; Kunz, Klaus; Gaertzen, Oliver; Benet-Buchholz, Jordi; Wesener, Joachim; US2004/198997; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131274-22-1,Tri-tert-butylphosphonium tetrafluoroborate,as a common compound, the synthetic route is as follows.

Step A (2E)-3-(2-Phenyl-5-pyrimidinyl)-2-propenoic Acid Methyl Ester Dioxane (1.3 mL) was added to a mixture of 5-bromo-2-phenylpyrimidine (310 mg, 1.32 mmol, prepared as described in Org. Lett. 2002, 4, 513), tri-t-butylphosphonium tetrafluoroborate (11 mg, 0.038 mmol), and tris(dibenzylideneacetone)dipalladium(0) (18 mg, 0.020 mmol). N-Methyldicyclohexylamine (0.31 mL, 1.45 mmol) and methyl acrylate (0.24 mL, 2.67 mmol) were added and the mixture was stirred for 72 h at room temperature. The mixture was diluted with ethyl acetate, filtered through a small plug of silica gel which was washed with additional ethyl acetate, and the combined filtrates were concentrated. The residue was triturated with 5:1 hexane/ethyl acetate and the solid was filtered and dried in vacuo to provide 178 mg (56%) of the title compound as an off-white solid. MS 241 (M+H)+.

131274-22-1 Tri-tert-butylphosphonium tetrafluoroborate 2734635, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Henninger, Todd C.; Macielag, Mark J.; Tennakoon, Manomi A.; Xu, Xiaodong; US2003/220272; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexylcarboxylic acid (136 mg, 1 mmol), 4-dimethylaminopyridine (DMAP, 18.3 mg, 0.15 mmol), dicyclohexylcarbodiimide (DCC, 340 mg, 1.65 mmol), and hydrogen peroxide to the reaction flask. (57 muL 1.9 mmol) and dichloromethane (5 mL), stirred at room temperature for 2 hours, filtered, and distilled off the solvent in the filtrate to obtain a concentrate;To the concentrate were added copper bromide (17.8 mg, 0.08 mmol), 6,6′-dimethyl-2,2′-bipyridine (14.7 mg, 0.08 mmol), and ethylene glycol dimethyl ether (1 mL). And diphenylphosphine (50.5 mg, 0.25 mmol), stirred at 60 oC, TLC monitoring until the end of the reaction;The crude product obtained after the reaction was separated by column chromatography (petroleum ether: acetone = 4: 1) to obtain the target product (yield 75%).

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

To a colourless solution of [(C6F5)2Pt(mu-PPh2)2Pt(NCMe)2] (0.150g, 0.127mmol) in acetone (5mL) was added dppf (0.071g, 0.127mmol). The resulting yellow solution was stirred at room temperature for 1h and then evaporated to 2mL. Complex 1 crystallized as a yellow solid, which was filtered, washed with Et2O (2¡Á2mL) and vacuum-dried. Yield: 0.178g, 85percent. Anal. Found (Calc. for C70H48F10FeP4Pt2): C, 51.07 (50.99); H, 3.08 (2.93). IR (Nujol, cm?1): 1161 (vs), 821 (s) dppf; 952 (vs), 781(vs) (Fermi res., C6F5), 772 (vs) (X-sensitive C6F5). 1H NMR (thf-d8, 295K, 400MHz): delta 4.10 (s, CbetaH, 4H), 4.41 (s, CgammaH, 4H), from 6.5 to 8.5 (m, Ph, 40H). 19F NMR (thf-d8, 300K, 376.5MHz): delta ?116.7 (4 o-F, 3JF,Pt(1)=325Hz), ?168.8 (m, 4 m-F), ?169.6 (t, 2 p-F, 3JF,F=20Hz); 31P{1H} NMR (thf-d8, 295K, 162MHz): delta 12.0 (m, 2JP(3),P(1)=2JP(4),P(2)=239Hz, 2JP(3),P(4)=55Hz, 2JP(3),P(2)=2JP(4),P(1)=14Hz, 1JP,Pt=2210Hz, P3/4), ?98.6 (m, 2JP(1),P(3)=2JP(2),P(4)=239Hz, 2JP(1),P(2)=111Hz, 2JP(1),P(4)=2JP(2),P(3)=14Hz, 1JP,Pt(1)=1802Hz, 1JP,Pt(2)=1745Hz, P1/2) ppm. 195Pt{1H} NMR (thf-d8, 295K, 86MHz): delta ?3761 (m, Pt1), ?4235 (m, Pt2), ppm.

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Giardina-Papa, Daniela; Ara, Irene; Ibanez, Susana; Mastrorilli, Piero; Gallo, Vito; Fornies, Juan; Polyhedron; vol. 120; (2016); p. 44 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

255835-82-6, Dicyclohexyl(2′-methoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

25 mL of Schlenk tube, 76.1 mg (0.2 mmol) of 2-dicyclohexylphosphino-2′-methoxybiphenyl was added,(1,5-cyclooctadiene) chlorine2.5 g of rhodium (I) dimer (2.5% of moles of raw material), 48 mg (0.6 mmol) of lithium tert-butoxide, Gas three times, under the protection of argon by adding 1,4-dioxane 1mL, bromobenzene 47.1mg (0.3mmol). 138 C for 36 hours and cooled After cooling at room temperature, the solvent was evaporated under reduced pressure, separated by 200-300 mesh silica gel column, petroleum ether: ethyl acetate = 100: 1 elution, true Dried in vacuo to give product 59.0 mg of a pale yellow solid in 65% yield

255835-82-6 Dicyclohexyl(2′-methoxy-[1,1′-biphenyl]-2-yl)phosphine 11794186, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl-2,2,4,4-tetramethyl chroman-6-carboxylate (Compound 23) A solution of 6-bromo-2,2,4,4-tetramethylchroman (synthesis is described in U.S. Pat. No. 6,252,090)(2.2 g, 8.08 mmol), palladium acetate (0.145 g, 0.65 mmol) and 1,3-bis(diphenylphosphino)propane (0.267 g, 0.65 mmol) in a mixture of N,N-dimethylformamide (25 mL), ethanol (20 mL) and triethyl amine (7 mL) was heated at 90 C. under an atmosphere of carbon monoxide overnight. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ethyl acetate. The combined organic extract was washed with brine (*1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to an oil which was subjected to flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent to afford the title compound (1.9 g, 90%). 1H NMR (300 MHz, CDCl3): delta8.00 (d, 1H, J=2.3 Hz), 7.76 (dd, 1H, J=2.1,8.5 Hz), 6.79 (d, 1H, J=8.5 Hz), 4.33(q, 2H, J=7.1 Hz), 1.85 (s, 2H), 1.36(s, 6H), 1.37 (s, 6H), 1.39-1.33(m, 3H).

As the paragraph descriping shows that 6737-42-4 is playing an increasingly important role.

Reference£º
Patent; Yuan, Yang-Dar; Vasudevan, Jayasree; Thacher, Scott; Chandraratna, Roshantha A.; US2004/77721; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4E)-5-(3-Pyridyl)-4-penten-2-ol. A mixture of 3-bromopyridine (7.50 g, 47.46 mmol), 4-penten-2-ol (4.90 g, 56.96 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (575 mg, 1.89 mmol), triethylamine (28.4 mL, 204.11 mmol) and acetonitrile (25 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (7.50 g, 81.0%).

6163-58-2 Tri-o-tolylphosphine 80271, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Caldwell, William S.; Dull, Gary M.; Bhatti, Balwinder S.; Hadimani, Srishailkumar B.; Park, Haeil; Wagner, Jared M.; Crooks, Peter A.; Lippiello, Patrick M.; Bencherif, Merouane; US2003/125345; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

trans-RuC12(slMes)(3-methyl-2-butenylidene)(Ph2P(OEt)), trans-C777: In an argon filled glove box, a 40 mL scintillation vial equipped with a magnetic stir bar was charged with C705 (2.000 g, 2.84 mmol) and dichloromethane (15 ml). To the stirring solution was added Phosphinite Ph2P(OEt) (0.607 mL, 2.84 mmol) in dichloromethane (5 mL). The reaction was stirred at room temperature for one hour then devolatilized. The resulting residue was recrystallized from toluene/pentane at -35 C affording trans-C777 (1.48 g, 67.2%, >95% purity). ?H NMR (400 MHz, CD2C12, ppm): oe18.39 (d, J= 11.2 Hz, 1H), 7.34 – 7.26 (m, 2H), 7.24 – 7.14 (m, 8H), 7.03 – 6.95 (m, 1H), 6.89 (s, 2H), 6.79 (s, 2H), 4.08 – 3.88 (m, 4H), 3.36 (pseudo pentet, J= 6.9 Hz, 2H), 2.56 (s, 6H), 2.36 (s, 6H), 2.32 (s, 3H), 2.24 (s, 3H), 1.11 (s, 3H), 1.07 (t, J= 6.9 Hz, 3H), 1.03 (s, 3H). 3?PNIVIR(161.8 IVIHz, CD2C12, ppm): oe 129.8 (s).

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

2622-14-2, Tricyclohexylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

As the paragraph descriping shows that 2622-14-2 is playing an increasingly important role.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

Example 253 0.031 mL of indoline, 0.12 g of cesium carbonate, 1.7 mg of tris(dibenzylideneacetone)dipalladium(0), 0.8 mg of palladium acetate and 4.4 mg of 2-dicyclohexylphosphino -2′,4′,6′-triisopropylbiphenyl were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 3 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain 77 mg of tert-butyl 2-(benzamido)-4-(indolin-1-yl)benzoate as yellow oil. 1H-NMR (CDCl3) delta: 1.63 (9H, s), 3. 17 (2H, t, J = 8.4 Hz), 4.10 (2H, t, J = 8.4 Hz), 6.86 (1H, td, J = 7.4, 0.8 Hz), 6.96 (1H, dd, J = 8.9, 2.5 Hz), 7.16-7.24 (2H, m), 7.46-7.57 (4H, m), 7.97 (1H, d, J = 8.9 Hz), 8.06-8.10 (2H, m), 8.81 (1H, d, J = 2.5 Hz), 12.40 (1H, s).

The synthetic route of 564483-18-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate