855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a 50 mL four-necked round-bottom flask, a magnetic stirrer bar, a Claisen distillation apparatus, a condenser, a thermometer, and a three-way stopcock were attached, and the inside was purged with nitrogen. Then, [RuCl2(p-cymene)]2 (459 mg, 0.75 mmol, 1.0 equivalents), tris(4-methoxyphenyl)phosphine (11-6) (581 mg, 1.65 mmol, 2.2 equivalents), and anhydrous THF (5 mL) were introduced sequentially, and the obtained dark red suspension was stirred at room temperature for 5 minutes. Subsequently, 2-diphenylphosphino-N-[2-(methylthio)ethyl]ethylamine (1D-1) (500 mg, 1.65 mmol, 2.2 equivalents) obtained in Example 1/Example 2 and 3M1B (10 mL) were added, and THF was removed by distillation at normal pressure using the Claisen distillation apparatus, followed by stirring for 1 hour under reflux in 3M1B.The reaction liquid was cooled to 5 C., and MeOH (20 mL) was added to the obtained yellowish orange suspension, followed by filtration by suction. Then, the crystals obtained by filtration were washed with MeOH, and dried by heating under reduced pressure to obtain 922 mg of title compound (8S-10) as a yellowish orange powder. Isolated yield: 73.5%, Purity: 99.0% by weight. Note that the major impurity was 3M1B.1H NMR (400 MHz, CD2Cl2): 31P NMR (161 MHz, CD2Cl2): delta=47.0-45.6 (m, 1P), 40.1-39.4 (m, 1P).
The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; NAKAYAMA, Yuji; OGATA, Osamu; (72 pag.)US2017/233418; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate