Day: August 20, 2020

13689-20-8, Cyclohexyldiphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a screw capped vial with a spinvane triangular-shaped Teonstir bar were added indicated arylphosphine oxide (0.20 mmol),[IrCp*Cl2]2 (3.2 mg, 0.0040 mmol, 2.0 mol %), AgNTf2 (6.6 mg,0.017 mmol, 8.5 mol %), O,O-dipivaloyl-L-tartaric acid (2.6 mg,0.040 mmol), 1,2-dichloroethane (0.5 mL), and p-toluenesulfonylazide (43.4 mg, 0.22 mmol) under atmospheric conditions. Thereaction mixture was stirred in a pre-heated oil bath at 60 C for18 h, and then ltered through a pad of Celite washing with EtOAc(10 mL3). Solvents were removed under reduced pressure and theresidue was puried by column chromatography to give the ami-dated product. Enantiomeric excess (ee) of amidated products ofthe crude reaction mixture was determined by chiral HPLC analysisusing ChiralPak IB-3 column with ethanol/hexane as eluents. 4.8.4. Compound 5d. White solid; mp 225e227 C; 1H NMR(600 MHz, CDCl3) d 11.52 (s,1H), 7.80 (dd, J8.5, 4.0 Hz,1H), 7.69 (d,J8.2 Hz, 2H), 7.65e7.58 (m, 2H), 7.50 (td, J7.4,1.6 Hz,1H), 7.42 (td,J7.7, 2.9 Hz, 2H), 7.41e7.34 (m, 1H), 7.20 (ddd, J12.4, 7.7, 1.6 Hz,1H), 7.07 (d, J8.0 Hz, 2H), 7.06e7.00 (m,1H), 2.30 (s, 3H), 2.21e2.11(m,1H),1.82e1.76 (m,1H),1.76e1.66 (m, 2H),1.60 (ddd, J12.3, 6.2,3.2 Hz, 1H), 1.55e1.37 (m, 3H), 1.26e1.16 (m, 3H); 13C NMR(150 MHz, CDCl3) d 144.4,143.1,136.8,132.7 (d, JCP2.3 Hz),131.8 (d,JCP2.7 Hz), 131.1 (d, JCP96.5 Hz), 130.8 (d, JCP9.9 Hz), 130.7 (d,JCP8.9 Hz, 2C), 129.3 (2C), 128.6 (d, JCP11.4 Hz, 2C), 127.2 (s, 2C),122.9 (d, JCP11.6 Hz), 120.3 (d, JCP7.0 Hz), 116.2 (d, JCP90.3 Hz),37.2 (d, JCP72.9 Hz), 26.1 (d, JCP10.2 Hz), 26.0 (d, JCP10.2 Hz),25.5, 24.2 (d, JCP2.9 Hz), 23.8 (d, JCP2.7 Hz), 21.4; 31P NMR(243 MHz, CDCl3) d 44.1; IR (diamond) 2930, 2853, 2807, 2746,1594,1573,1491,1448,1439,1418,1339,1266,1161,1131,1106,1089,943, 872, 812, 779, 712, 695 cm1; HRMS (EI) m/z calcd forC25H28NO3PS [M]: 453.1528, found: 453.1526.

The synthetic route of 13689-20-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gwon, Donghyeon; Park, Sehoon; Chang, Sukbok; Tetrahedron; vol. 71; 26-27; (2015); p. 4504 – 4511;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

To a Schlenk flask charged with a solution of [Ph2P(o-tolyl)] (1 g, 3.61 mmol) in hexane (40 mL),tetramethylethylenediamine, TMEDA (0.54 mL, 3.61 mmol) and nBuLi (1.44 mL of a hexane solution,3.61 mmol) were added at -78 C with stirring. The reaction mixture was then kept at 0 C for 16 h,after which it was filtered and dried under reduced pressure yielding an extremely air and moisturesensitive yellow-orange solid. Crystals for the X-ray experiment were obtained from benzene. Yield:(1.24 g, 86%). m.p.: 146-148 C. 1H NMR (500 MHz, C6D6, 298 K): delta 7.57 (m, 4H, CH arom), 7.36 (m, 1H,CH arom), 7.16 (m, 1H, CH arom), 7.09 (m, 3H, CH arom), 7.03 (m, 2H, CH arom), 6.99 (m, 1H, CH arom),6.73 (m, 1H, CH arom), 6.19 (m, 1H, CH arom), 2.35 (br, 2H, CH2Li), 1.85 (s, 12H, CH3N), 1.65 (s, 4H,CH2N). 13C{1H} NMR (100.68 MHz, C6D6, 298 K): delta 43.71 (d, CH2-Li, 3JP,C = 17.5 Hz), 45.57 (s, CH3N),56.87 (s, CH2N), 108.12 (s, CH, o-tolyl), 120.68 (s, CH, o-tolyl), 127.94 (s, CH, Phenyl), 128.03 (d, CH,3JP,C = 7.4 Hz, Phenyl), 128.3 (s, CH, o-tolyl), 128.80 (s, CH, Phenyl), 132.79, (s, CH, o-tolyl), 133.9 (d, CH,2JP,C = 20.1 Hz, o-tolyl), 134.2 (s, CH, 2JP,C = 17.5 Hz, Phenyl), 136.27 (d, C-P, 1JP,C = 12.57 Hz, o-tolyl),136.66 (d, C-P, 1JP,C = 11.3 Hz, Phenyl), 157.5 (d, C-P, 1JP,C = 26.39 Hz, o-tolyl). 31P{1H} NMR (161.92MHz, C6D6, 298 K): delta 15.30 (s, w1/2 4 Hz).). 7Li NMR (155.45 MHz, C6D6, 298 K): delta 1.59 (s). IR(KBr/cm-1): 3059 (m), 2962 (m), 1585 (m), 1470 (m), 1434 (m), 1258 (m), 1176 (m), 1088 (m), 1026 (m),803 (m), 742 (s), 693 (s), 551 (m), 511 (m).

The synthetic route of 5931-53-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rufino-Felipe, Ernesto; Mu Oz-Hernandez, Miguel-Angel; Montiel-Palma, Virginia; Molecules; vol. 23; 1; (2018);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Example 3 Dinaphthylphosphine-borane complex Under an argon atmosphere, 4 mL of toluene was added to dinaphthylphosphine oxide synthesised in Reference Example 2 (0.6061 g, 2.00 mmol) at a room temperature (25C) and the mixture was stirred to obtain a suspension. Then, to the suspension was added 1.02 mol/L of a borane-tetrahydrofuran complex (5 mL, 2.55 equivalents). The reaction mixture was purified by silica gel column chromatography (silica gel 15 g, toluene) and the desired fraction was concentrated under reduced pressure. The residue was dried (under reduced pressure at 40C) to obtain the titled compound (0.4577 g, white powder). The yield was 76.2%. 1H-NMR (300 MHz, CDCl3, TMS) delta: 0.60-1.85 (m, 3 H), 6.56 (dq, 1 H, JH-P= 378.7 Hz, J = 6.9 Hz), 7.52-8.31 (m, 14H). 13C-NMR (75 MHz, CDCl3, CDCl3) delta: 124.40, 125.16, 128.53, 129.22, 129.31, 129.61, 129.96, 130.30, 130.43, 134.20, 134.36, 135.91, 135.94, 135.99, 136.14. 31P-NMR (121 MHz, CDCl3, 85% H3PO4) delta: 1.10-2.21 (m), 3.92-4.95 (m).

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1626052; (2006); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 12 (mu-SCH2CH2CH2S-mu)Fe2(CO)6 (0.193g, 0.5mmol) and 13 2-(diphenylphosphino)benzaldehyde (0.145g, 0.5mmol) in 14 CH2Cl2 (20mL) was added a solution of 15 Me3NO¡¤2H2O (0.056g, 0.5mmol) in 16 MeCN (10mL). The mixture was stirred at room temperature for 1h and then the solvent was reduced on a rotary evaporator and the residue was subjected to TLC separation using CH2Cl2/17 petroleum ether=1:1 (v/v) as eluent.

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Reference£º
Article; Sheng, Yu-Dong; Yu, Xiao-Yong; Liu, Xu-Feng; Li, Yu-Long; Polyhedron; vol. 137; (2017); p. 134 – 139;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 50 mL four-necked round-bottom flask, a magnetic stirrer bar, a Claisen distillation apparatus, a condenser, a thermometer, and a three-way stopcock were attached, and the inside was purged with nitrogen. Then, [RuCl2(p-cymene)]2 (459 mg, 0.75 mmol, 1.0 equivalents), tris(4-methoxyphenyl)phosphine (11-6) (581 mg, 1.65 mmol, 2.2 equivalents), and anhydrous THF (5 mL) were introduced sequentially, and the obtained dark red suspension was stirred at room temperature for 5 minutes. Subsequently, 2-diphenylphosphino-N-[2-(methylthio)ethyl]ethylamine (1D-1) (500 mg, 1.65 mmol, 2.2 equivalents) obtained in Example 1/Example 2 and 3M1B (10 mL) were added, and THF was removed by distillation at normal pressure using the Claisen distillation apparatus, followed by stirring for 1 hour under reflux in 3M1B.The reaction liquid was cooled to 5 C., and MeOH (20 mL) was added to the obtained yellowish orange suspension, followed by filtration by suction. Then, the crystals obtained by filtration were washed with MeOH, and dried by heating under reduced pressure to obtain 922 mg of title compound (8S-10) as a yellowish orange powder. Isolated yield: 73.5%, Purity: 99.0% by weight. Note that the major impurity was 3M1B.1H NMR (400 MHz, CD2Cl2): 31P NMR (161 MHz, CD2Cl2): delta=47.0-45.6 (m, 1P), 40.1-39.4 (m, 1P).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; NAKAYAMA, Yuji; OGATA, Osamu; (72 pag.)US2017/233418; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78percent).2

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(diphenylphosphino)benzaldehyde (0.290g, 1mmol) and 2-thiophene carboxylic acid hydrazide (0.126g, 1mmol) in ethanol (20mL) were added 2?3 drops of glacial acetic acid. The resulting solution was heated under reflux over a 3h period, and then concentrated to ca. 3mL. The white crystalline precipitate was filtered off, washed with diethyl ether (2¡Á5mL), and dried under vacuo. Yield: 87percent (0.36g). Mp: 197?199¡ãC. Anal. Calcd for C24H19N2OPS: C, 69.55; H, 4.62; N, 6.76; S, 7.74. Found: C, 69.67; H, 4.58; N, 6.86; S, 7.69. IR (KBr disks, cm?1): 3195 (m, nuNH); 1685 (s, nuC=O); 1583+1474 (s, nuC=N+nuC?N). 1H NMR (400MHz, DMSO?d6, ppm): 6.83?7.50 (m, 14H, Ar H), 7.57 (t, 1H, J=6.24, Hz Ar H), 8.05 (s, 1H, Ar H), 8.15 (s, 1H, Ar H), 8.85 (d, IH, J=3.6Hz, ?CH=N), 9.13 (s, 1H, Ar H), 11.98 (s, IH, ?NH). 13C NMR (100MHz, DMSO?d6, ppm): 125.78 (Ar C), 128.91 (Ar C), 129.15 (Ar C), 129.47 (Ar C), 130.07 (Ar C), 133.30 (Ar C), 133.49 (Ar C), 134.12 (Ar C), 135.62 (Ar C), 138.25 (Ar C), 149.52 (?CH=N), 158.12 (C=O). 31P NMR (162MHz, DMSO?d6, ppm): ?17.14.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Ramachandran; Prakash; Viswanathamurthi; Malecki; Inorganica Chimica Acta; vol. 477; (2018); p. 122 – 129;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Similar procedure described for 1c was used in the synthesis of 5c by using dppbz instead of dppm to obtain a pale yellow solid. Yield: 94%. 31P-NMR (121.42 MHz, 298 K, CDCl3):62.4 ppm (d, 1J(Rh-P) = 134 Hz). 1H-NMR (300 MHz,298 K, CDCl3): 7.38-6.75 (m, 24H, Ph). ESI-MS(?):501.3 (M?-CO-Ph, calc.: 501.3). IR (KBr, cm-1) 1970,m(C:O); 1103, 1032 (OTf-).

The synthetic route of 13991-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arcau, Julia; Ferrer, Montserrat; Aguilo, Elisabet; Rodriguez, Laura; Transition Metal Chemistry; vol. 42; 1; (2017); p. 57 – 67;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl diphenyl phosphinite (12.6 g, 55 MMOL) is added, at 60C and under argon, to a solution of the compound of formula (37) (15.2 g, 36.6 MMOL) IN toluene (370 ml). The reaction mixture is stirred at 60C for 3 hours and then concentrated. The residue is dissolved in 10 ml of toluene, and 10 ml of hexane are added, the product precipitating out in the form of a colourless powder, which is filtered off. In that manner, 14.3 G (73 %) of the phosphine oxide (38) can be obtained. aH NMR (300 MHz, CDCI3) : 1.22 (d, J = 6.7 Hz, 6H); 3.32-3. 45 (m, 1H); 3.41 (s, 3H); 3.47 (s, 3H); 3.89 (d, J = 12.9 Hz, 2H); 6.86 (dd, J = 8.7, 8.7 Hz, 2H); 7.09 (dd, J = 8.6, 5.3 Hz, 2H); 7.27-7. 45 (m, 10H). 13C NMR (75 MHz, CDCI3) : 22.1, 30.0 (JCP = 64.8 Hz), 33.1, 33.5, 42.7, 114.1 (Jcp = 8.2 Hz), 115.5 (JCF = 21.7 Hz), 128.8 (Jcp = 11. 8 Hz), 130.9 (Jcp = 9.3 Hz), 132.1 (JCF = 8.4 Hz), 132.1 (Jcp = 2.9 Hz), 133.3, 134.7 (Jcp = 2.3 Hz), 157.3 (Jcp = 2.3 Hz), 162.9 (JCF = 249 Hz), 166.3 (Jcp = 4.6 Hz). 3’P NMR (121 MHz, CD13) : 27.7.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; CIBA SPECIALTY CHEMICALS HOLDING INC.; WO2004/103977; (2004); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Embodiment 1 Synthesis of Compounds 8 and 9 Ammonium chloride (0.01 g) and Compound 7 (1 mmol) were charged to a 30 mL flask. The mixture was dissolved in toluene (10 mL), hexamethyl phosphorus triamide was added, and the mixture was refluxed for 12 hours. After allowing the mixture to cool to room temperature, the solvent was distilled off. The residue was recrystallized from methylene chloride/pentane (yield 75 percent, R=Me).

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Patent; Japan Science and Technology Agency; EP1854802; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate