With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.
Example 221A 6-(tert-butyl)-2-methoxynicotinaldehyde A 500 mL flask was charged with palladium acetate (0.511 g, 2.277 mmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (1.933 g, 4.55 mmol), and cesium carbonate (37.1 g, 114 mmol). After purging the flask with N2, toluene (75 mL) was added, and the mixture was heated in a preheated heating block to 80 C. After 5 minutes, the flask was cooled to room temperature, and 6-(tert-butyl)-2-chloronicotinaldehyde (15 g, 76 mmol) was added as a solution in methanol (75 mL). The mixture was heated at 67 C. for 2 hours, and cooled to room temperature. The reaction was quenched by the addition of saturated aqueous ammonium chloride solution, the mixture was partitioned between water and methyl tert-butyl ether, and the organic phase was washed with brine and dried over sodium sulfate. After filtration, the mixture was concentrated in vacuo, and the residue was purified by silica gel chromatography, eluting with 0 to 10% ethyl acetate/heptanes, to afford the title compound. 1H NMR (501 MHz, CDCl3) delta ppm 10.35 (s, 1H), 8.06 (d, J=7.8 Hz, 1H), 7.06-6.99 (m, 1H), 4.09 (s, 3H), 1.38 (s, 9H); MS (ESI+) m/z 194.1 (M+H)+.
As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.
Reference£º
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate