Day: August 19, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.30 methyl 2-phenyl-5-(4-methoxylphenyl)oxazole-4-carboxylate (4j) A suspension of Pd(OAc)2 (10 mol %), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 72 mg (47%). White solid, mp 131-132.5 C; 1H NMR (300 MHz, CDCl3) delta 3.87 (s, 3H), 3.97 (s, 3H), 7.01 (d, J=8.9 Hz, 2H), 7.46-7.48 (m, 3H), 8.12-8.15 (m, 4H) ppm; 13C NMR (75 MHz, CDCl3) delta 162.4, 160.7, 158.6, 155.1, 130.4, 129.7, 128.3, 126.2, 126.0, 119.0, 113.4, 54.9, 51.8 ppm; IR (KBr) 2962, 2926, 2855, 1729, 1465, 1330, 1261, 1108, 1069, 1020, 802, 761, 686 cm-1; HRMS (ESI) calcd for [C18H15NO4+H]+ 310.1074, found 310.1066.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 Preparation of N,N’-bis{[2-(diphenylphosphino)phenyllmethvlenel-2,2-dimethyl-1,3-propanediamine (L-5) Under argon, a solution of 2-(diphenylphosphino)benzaldehyde (522.7 mg, 1.8 mmol) and 2,2-dimethyl-1,3-propanediamine (93.3 mg, 0.9 mmol) in toluene (15 mL) was stirred at room temperature for 15 h. Then the reaction mixture was heated at 80; C. (oil bath) for 2,5 h. Next, the solvent was removed in vacuo, and an orange solid was recovered (476.8 mg, 0.74 mmol, 82percent). 1H NMR (CD2Cl2, 400 MHz): delta 8.78 (d, J=4.6 Hz, 2H), 7.96 (dd, J=7.7, 4.1 Hz, 2H), 7.3-7.2 (m, 24H), 6.87 (dd, J=7.7, 4.1Hz, 2H), 3.19 (s, 4H), 0.69 (s, 6H). 13C NMR (CD2CL2, 100 MHz): delta 160 (d, J=20.2 Hz, CH=N), 140.3 (d, J=17.8 Hz, Carom), 137.7 (d, J=20.2 Hz, Carom), 137.4 (d, J=10.5 Hz, Carom), 134.4 (d, J=20.2 Hz, CHarom), 134.1 (d, J=20.2 Hz, CHarom), 133.7 (CHarom), 130.2 (CHarom), 129.1 (CHarom), 128.9 (d, J=7.3 Hz, CHarom), 128.4 (d, J=4.8 Hz, CHarom), 70.7 (CH2), 36.9 (C), 24.4 (CH3). 31P{1H}NMR (CD2CL2, 100 MHz): delta -12.8.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SAUDAN, Lionel; Dupau, Philippe; Riedhauser, Jean-Jacques; Wyss, Patrick; US2008/71098; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

29949-84-6, Tris(3-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under a N2 atmosphere, phosphine ligand (2 mmol) (L) was added to a stirred solution of Co2(CO)8 (1 mmol) in tetrahydrofuran or toluene (10 mL). The reaction mixture was stirred for 1 h under CO bubbling at 50 C. The organic solvent was evaporated under reduced pressure. The resulting solid was washed several times with diethyl ether and pentane, finally dried under vacuum to give the desired complex.

As the paragraph descriping shows that 29949-84-6 is playing an increasingly important role.

Reference£º
Article; Amezquita-Valencia, Manuel; Ramirez-Garavito, Ricardo; Toscano, Ruben A.; Cabrera; Catalysis Communications; vol. 33; (2013); p. 29 – 33;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of [Fe2(CO)6{mu-SC6H3(CH3)S}] (0.043 g,0.1 mmol) and ethyl diphenylphosphinite (0.023 g,0.1 mmol) in CH2Cl2(5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 1:4(v/v) as eluent. From the main red band, 0.056 g (88%) of complex 2 was obtained as a red solid. IR (CH2Cl2, cm-1):nuC?O 2048 (vs), 1991 (vs), 1937 (m). 1H NMR (500 MHz,CDCl3):7.55 (q, J = 9 Hz, 4H, PhH), 7.40-7.32 (m, 6H,PhH), 6.57 (d, J = 7.5 Hz, 1H, C6H3H),6.30 (s, 1H, C6H3H),6.17 (d, J = 7.5 Hz, 1H, C6H3H),3.92-3.83 (m, 2H, OCH2),1.93 (s, 3H, C6H3CH3),1.28 (t, J = 7 Hz, 3H, CH2CH3)ppm.31P{1H} NMR (200 MHz, CDCl3,85% H3PO4):162.12 (s)ppm. Anal. Calcd. for C26H21Fe2O6PS2:C, 49.08; H, 3.33.Found: C, 48.88; H, 3.56%.

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Lin, Hui-Min; Mu, Chao; Li, Ao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Transition Metal Chemistry; vol. 44; 5; (2019); p. 491 – 498;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Example 221A 6-(tert-butyl)-2-methoxynicotinaldehyde A 500 mL flask was charged with palladium acetate (0.511 g, 2.277 mmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (1.933 g, 4.55 mmol), and cesium carbonate (37.1 g, 114 mmol). After purging the flask with N2, toluene (75 mL) was added, and the mixture was heated in a preheated heating block to 80 C. After 5 minutes, the flask was cooled to room temperature, and 6-(tert-butyl)-2-chloronicotinaldehyde (15 g, 76 mmol) was added as a solution in methanol (75 mL). The mixture was heated at 67 C. for 2 hours, and cooled to room temperature. The reaction was quenched by the addition of saturated aqueous ammonium chloride solution, the mixture was partitioned between water and methyl tert-butyl ether, and the organic phase was washed with brine and dried over sodium sulfate. After filtration, the mixture was concentrated in vacuo, and the residue was purified by silica gel chromatography, eluting with 0 to 10% ethyl acetate/heptanes, to afford the title compound. 1H NMR (501 MHz, CDCl3) delta ppm 10.35 (s, 1H), 8.06 (d, J=7.8 Hz, 1H), 7.06-6.99 (m, 1H), 4.09 (s, 3H), 1.38 (s, 9H); MS (ESI+) m/z 194.1 (M+H)+.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: DMPE (102 muL, 0.616 mmol) was slowly added to a yellow suspension of [Pd(TFA)2(TMEDA)] (0.138 g, 0.31 mmol) in CH2Cl2 (3 mL). An initial suspension turned gray. After stirring the reaction mixture for 2 h at room temperature, the solvent was removed under vacuum, and washed with n-hexane. The crude solid was recrystallized from CH2Cl2/hexane to give [Pd(P~P)2](TFA)2 (P~P = DMPE), 2 (0.192 g, 99percent). Complexes 3?8 were analogously prepared. Analytical and spectroscopic data are available as Supporting Information.

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Kim, Kun-Woo; Kim, Yong-Joo; Lim, Hye Jin; Lee, Soon W.; Bulletin of the Korean Chemical Society; vol. 36; 12; (2015); p. 2952 – 2955;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 2-iodophenol (21c) (1.32 g, 6.00 mmol) and bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide (22) (2.85 g, 6.01 mmol) dissolved in CCl4 (30 mL) was added triethylamine (1.67 mL, 12.0 mmol) at 0 C. After stirring for 15 min at the same temperature, to the mixture was added an aqueous saturated solution of NH4Cl (40mL). The mixture was extracted with CH2Cl2 (50 mL ¡Á 3), and the combined organicextract was dried (Na2SO4), and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel100 g, n-hexane/EtOAc = 19/1 to 9/1) to give 2-iodophenyl bis(3,5-bis(trifluoromethyl)-phenyl)phosphinate (23c) (3.67 g, 5.30 mmol, 88.4%) as a colorless solid.

The synthetic route of 15929-43-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nishiyama, Yoshitake; Kamada, Shuhei; Yoshida, Suguru; Hosoya, Takamitsu; Chemistry Letters; vol. 47; 9; (2018); p. 1216 – 1219;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 2-(diphenylphosphino)benzaldehyde (0.279 g, 0.961 mmol) in CH2Cl2 (10 ml) in a Schlenk tube was added 2-methylaniline (0.103 g, 0.961 mmol) dropwise. Anhydrous magnesium sulfate (~ 0.5 g) was added to the Schlenk tube and the reaction was stirred at room temperature for 20 h. The resulting yellow mixture was filtered to obtain a yellow solution, which gave yellow oil upon evaporation of the solvent. Yield: 0.2990 g (82percent);

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Reference£º
Article; Motswainyana, William M.; Onani, Martin O.; Madiehe, Abram M.; Saibu, Morounke; Thovhogi, Ntevheleni; Lalancette, Roger A.; Journal of Inorganic Biochemistry; vol. 129; (2013); p. 112 – 118;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 2-ethynylpyridine (0.052 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI (0.019 g, 0.1 mmol), di-tert-butyl peroxide(0.30 g, 2 mmol), and acetone (2 mL),50oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product. (Yield 63%).

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate