With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.
1.28 g (3.42×10″3 moles) of trichlorotris(tetrahydrofuran)vanadium [VCI3(THF)3], 15 ml of toluene and, subsequently, 2.90 g (1.37×10~2 moles) of (ethyl)diphenylphosphine (P/V molar ratio = 4) were placed into a 100 ml tailed flask. The mixture obtained was left, under vigorous stirring, at room temperature, for 15 minutes and, then, heated under reflux for 1 hour. The suspension obtained was filtered in the hot (60C) and the fraction collected was concentrated, under vacuum, at room temperature. Subsequently, drop by drop, under stirring, about 50 ml of pentane were added, obtaining the precipitation of a purple/gray powder. After about 3 hours, everything was filtered and the solid gray/pink residue obtained was washed with pentane (50 ml) and dried, under vacuum, at room temperature, obtaining 1.8226 g (conversion with respect to starting [VCI3(THF)3] = 91.0%) of complex VCI3(PEtPh2)2 (molecular weight = 585.79 gxmol”1). (0146) Elementary analysis [found (calculated)] C: 57.40% (57.41%); H: 5.10% (5.16%); CI: 18.20% (18.16%); P: 10.07% (10.58%); V: 8.60% (8.70%). (0147) Figure 2 reports the XRD structure of the VCI3(PEtPh2)2 complex obtained. (0148) Table 1 and Table 2 report the crystallographic data of the VCI3(PEtPh2)2 complex obtained
The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VERSALIS S.P.A.; RICCI, Giovanni; LEONE, Giuseppe; SOMMAZZI, Anna; FORNI, Alessandra; MASI, Francesco; (110 pag.)WO2016/128812; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate