Day: August 18, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

1.28 g (3.42×10″3 moles) of trichlorotris(tetrahydrofuran)vanadium [VCI3(THF)3], 15 ml of toluene and, subsequently, 2.90 g (1.37×10~2 moles) of (ethyl)diphenylphosphine (P/V molar ratio = 4) were placed into a 100 ml tailed flask. The mixture obtained was left, under vigorous stirring, at room temperature, for 15 minutes and, then, heated under reflux for 1 hour. The suspension obtained was filtered in the hot (60C) and the fraction collected was concentrated, under vacuum, at room temperature. Subsequently, drop by drop, under stirring, about 50 ml of pentane were added, obtaining the precipitation of a purple/gray powder. After about 3 hours, everything was filtered and the solid gray/pink residue obtained was washed with pentane (50 ml) and dried, under vacuum, at room temperature, obtaining 1.8226 g (conversion with respect to starting [VCI3(THF)3] = 91.0%) of complex VCI3(PEtPh2)2 (molecular weight = 585.79 gxmol”1). (0146) Elementary analysis [found (calculated)] C: 57.40% (57.41%); H: 5.10% (5.16%); CI: 18.20% (18.16%); P: 10.07% (10.58%); V: 8.60% (8.70%). (0147) Figure 2 reports the XRD structure of the VCI3(PEtPh2)2 complex obtained. (0148) Table 1 and Table 2 report the crystallographic data of the VCI3(PEtPh2)2 complex obtained

The synthetic route of 607-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERSALIS S.P.A.; RICCI, Giovanni; LEONE, Giuseppe; SOMMAZZI, Anna; FORNI, Alessandra; MASI, Francesco; (110 pag.)WO2016/128812; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

Example 584 86 mg of 4-phenylpiperidine, 0.22 g of cesium carbonate, 2.4 mg of tris(dibenzylideneacetone)dipalladium(0), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added to 3.0 mL of toluene solution containing 0.10 g of tert-butyl 2-(benzamido)-4-bromobenzoate, and the resulting mixture was heated to reflux for 2 hours. After the reaction mixture was cooled to room temperature, 2.4 mg of tris(dibenzylideneacetone)dipalladium(O), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added and the resulting mixture was heated to reflux for 6 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain tert-butyl 2-(benzamido)-4-(4-phenylpiperidin-1-yl)benzoate as pale yellow solid.

As the paragraph descriping shows that 564483-18-7 is playing an increasingly important role.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

To a 500 mL reaction was added 10 g (1,5-cyclooctadiene) palladium dichloride, the reaction flask was replaced with a nitrogen atmosphere,19.6 g of di-tert-butyl-4-dimethylaminophenylphosphine prepared in Example 1 and 200 mL of anhydrous tetrahydrofuran were added, and the mixture was stirred at room temperature for 16 hours,There is a solid precipitation,Filtration and drying gave a pale yellow powder product bis (di-tert-butyl-4-dimethylaminophenylphosphine) palladium chloride 24. 1 g,The yield was 97% (yield based on (1,5-cyclooctadiene) palladium dichloride)The purity of the product was 99.8% by XY-1A intelligent element analyzer.

As the paragraph descriping shows that 932710-63-9 is playing an increasingly important role.

Reference£º
Patent; Panjin Ge Linkaimo Technology Co., Ltd.; Rao Zhihua; Gong Ningrui; (9 pag.)CN105237568; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 8A N-(2-Fluoro-4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 500 mg (3.28 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (Schneller, Stewart, W.; Luo, Jiann-Kuan; J. Org. Chem. 1980, 45, 4045-4048.), 614 mg (3.93 mmol) of 2-fluoro-4-nitroaniline, 150 mg (0.16 mmol) of tris(dibenzylidenacetone)dipalladium and 156 mg (0.33 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 996 mg (7.21 mmol) of potassium carbonate in 5.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. After cooling to RT, the mixture is filtered through Celite, the Celite is washed with ethyl acetate and the filtrates are concentrated under reduced pressure. The residue is purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 1:1). Yield: 694 mg (78% of theory)

As the paragraph descriping shows that 564483-18-7 is playing an increasingly important role.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After dissolving 3-amino-2-naphthol (0.159 g, 1.0 mmol), 2 (diphenylphosphino) benzoic acid (0.306 g, 1.0 mmol) and paratoluenesulfonicacid (0.190 g, 1.0 mmol) in 30 ml of toluene,The mixture was stirred at 150 under N2 (g) air flow for 15 hours.The product was separated into H2O and toluene layers using H2O,after toluene layer only collected separately dissolved in minimum amount of CHCl3 and the solvent evaporated in evaporator was performed by a silica gel column (Merck 60, 70-230 mesh).The column was prepared using a solution of CHCl3: ethyl acetate in a volume ratio of 5: 1 (v: v),The extracted product was recrystallized with CHCl3 and ethyl acetate in a volume ratio of 5: 2. The recrystallized product was dissolved in 10 ml of CH2Cl2,While stirring, 2 ml of H2O2 (30percent) was slowly added dropwise and the reaction was allowed to proceed overnight.The product was separated into a H2O layer and a CH2Cl2 layer using H2O,The CH2Cl2 layer alone was collected and the solvent was evaporated by evaporator and 2- (2-diphenylphosphoryl) phenyl) naphtho [2,3-d] oxazole (2-PPN),obtained.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Inje university industry-academic cooperation foundation; Lee, Bum-Jong; Kim, Ik-Hwan; Kang, Eun-Guk; Kim, Kyung-Hyun; (23 pag.)KR101581821; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19845-69-3,1,6-Bis(diphenylphosphino)hexane,as a common compound, the synthetic route is as follows.

General procedure: [Cu(MeCN)4]ClO4 (0.025g, 0.076mmol) was taken in a double neck Round Bottom flask dissolved in dry MeOH by magnetic stirring under N2 atmosphere. Then 1,3-bis(diphenylphosphino)propane (dppp) (0.0314g, 0.076mmol) was added to this solution and stirred magnetically. After half an hour L (0.019g, 0.076mmol) was added to the reaction mixture and stirred for another 2h. The solution colour turned to red. It was filtered and kept undisturbed for crystallisation.

As the paragraph descriping shows that 19845-69-3 is playing an increasingly important role.

Reference£º
Article; Roy, Suman; Mondal, Tapan Kumar; Layek, Animesh; Saha, Rajat; Sinha, Chittaranjan; Inorganica Chimica Acta; vol. 469; (2018); p. 523 – 535;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of methyl iodide (1.14 g, 8 mmol) was added dropwise for 1 min to the stirringmixture of tertiary phosphine (4 mmol) in anhydrous tetrahydrofuran (16 mL) at roomtemperature. After the mixture was stirred at room temperature for 12 h, the mixture wasevaporated in vacuo. The residue was washed with ether, and the precipitate was dried invacuo for 12 h at 40 C to give corresponding quaternary phosphonium iodide as a whitepowder.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Aoyagi, Naoto; Furusho, Yoshio; Endo, Takeshi; Tetrahedron Letters; vol. 54; 51; (2013); p. 7031 – 7034;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

Phosphine 1 (0.22 g, 0.723 mmol) dissolved in EtOH (5 ml) andaq.H2O2 (34%, 0.075 g) was added and resulted mixture was stirredduring 1 h at room temperature. In 1 h MnO2 was added to quenchthe traces of H2O2. Then the mixture was filtered through K2CO3and EtOH was removed in vacuum to give the phosphine oxide 2 aswhite powder.Yield 0.229 g (99%). M.p. 148-150 C (heptane), FTIR (KBr, cm-1):3024, 2921, 2862, 2819, 1922, 1820, 1656, 1599, 1499, 1444, 1399,1310, 1175, 1115, 1025, 807, 660, 523, 464; 1H NMR (400.13 MHz,CDCl3, delta, ppm): 2.35 (Me, 9H, s), 7.16 (3,5-H, C6H4, 6H, br.d,3JHH =7.9 Hz), 7.52 (2,6-H, C6H4, 6H, dd, 3JHH =7.9 Hz,3JPH =11.8 Hz). 13C NMR (100.62 MHz, CDCl3, delta, ppm): 21.55 (Me),129.14 (3,5-C, C6H4, d, 3JPC =12.6 Hz), 129.45 (1-C, C6H4, d,1JPC= 107.5 Hz), 132.10 (2,6-C, C6H4, d, 2JPC =10.4 Hz), 142.21 (4-C,C6H4, d, 4JPC= 2.8 Hz); 31P NMR (161.98 MHz, CDCl3, delta, ppm): 27.49.For C21H21PO calcd (%): , 78.73; , 6.61; , 9.67. Found: , 78.65; ,6.59; , 9.47.

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sterkhova; Smirnov; Malysheva; Kuimov; Belogorlova; Journal of Molecular Structure; vol. 1197; (2019); p. 681 – 690;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the chloro derivative of pyridoxine 9 (1 equiv) in 30 ml of acetonitrile were added trisubstituted phosphine (1?5 equiv). The reaction mixture was refluxed for 7 h. Different workup procedures were used for preparation of phosphonium salts.

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pugachev, Mikhail V.; Shtyrlin, Nikita V.; Sapozhnikov, Sergey V.; Sysoeva, Lubov P.; Iksanova, Alfiya G.; Nikitina, Elena V.; Musin, Rashid Z.; Lodochnikova, Olga A.; Berdnikov, Eugeny A.; Shtyrlin, Yurii G.; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7330 – 7342;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate