With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.
Tris(dimethylamino)phosphine (2.29g, 14mmol) was added drop-wise to a stirred solution of 2-methylprop-2-en-1-ol (1g, 14mmol) and CCl4 (2.46g, 16mmol) in dry CH2Cl2 (30mL) cooled at-30C. Then, 15mL of distilled water was added and the reaction mixture was allowed to proceed at room temperature for 2h. Organic phase was decanted and extracted with water (2¡Á40mL). Aqueous phases were collected, washed with Et2O and decanted to give an aqueous solution of methallyloxyphosphonium chloride. After the addition of KPF6 (3.68g, 20mmol) in 10mL of water, an immediate precipitate was formed. The mixture was filtered and the crude product was washed with Et2O and dried under vacuum. Recrystallization from a mixture of chloroform: Et2O solution afforded salt 2 as a white solid. Yield: 4.15g (78%). IR [nu cm-1]: 836 (PF6-). 1H NMR (300MHz, CDCl3): 1.78 (s, 3H, CH3-allyl); 2.76 (d, 18H, (CH3)2N); 4.54 (d, 2H, CH2-O); 5.01 (s, 1H, CH2); 5.08 (s, 1H, CH2). 13C NMR (75.47MHz, CDCl3): 18.7 (CH3-allyl); 36.7 (CH3-N); 71.9 (CH2-O); 114.3 (CH2); 137.7 (C).
As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.
Reference£º
Article; Dridi, Sana; Mechria, Ali; Msaddek, Moncef; Journal of Organometallic Chemistry; vol. 772-773; (2014); p. 217 – 221;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate