With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.
General procedure: To a solution of tertiary phosphine oxides 2 (0.4mmol) in CH2Cl2 (2mL) was added oxalyl chloride (0.4mmol) dropwise at room temperature under an argon atmosphere. After 30min, HEH (1mmol) was added to the mixture in one portion as well as TEA (3mmol). The mixture was stirred for another 2h at 40C, and then diluted with H2O (10mL). The resulting mixture was extracted with CH2Cl2 repeatedly. The extracts were dried (anhydrous Na2SO4) and evaporated. The crude product was purified by column chromatography on silica gel using ethyl acetate/petroleum ether to afford the pure product.
13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Article; Zhang, Tong-Xin; Zhang, Wei-Xi; Luo, Mei-Ming; Chinese Chemical Letters; vol. 25; 1; (2014); p. 176 – 178;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate