Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Example 1 Diphenyl(phthalimidomethyl)phosphine oxide IV Toluene (25 ml) was added to a mixture of ethyl diphenylphosphinite (5 g, 21.71 mmole) and the N-(bromomethy)phthalimide III (5.21 g, 21.70 mmole) at room temperature. The reaction mixture was heated to 90 C. and maintained at this temperature for 48 h when the reaction was complete as indicated from the TLC of the reaction mixture. The reaction mixture was concentrated under reduced pressure, triturated with toluene and filtered to furnish the phosphine oxide compound IV as a solid; yield: 6 g, 76.5%.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; HELVETICA INDUSTRIES (P) LIMITED; US2011/263870; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

A mixture of 0.23 g (0.6 mmol) of iodo aminoester (S)-2-(t-butyloxycarbonylamino)allyl-4-iodobutanoate (III’) and 0.42 g (1.2 mmol) of [tri-(4- methoxyphenyl)]phosphine in 0.5 mL of dry THF was stirred under argon at 80C. After three hours, 3 mL of toluene followed by 30 mL of diethyl ether were added to the mixture at room temperature. The white precipitate was washed with 2 x 25 mL of diethyl ether and purified by chromatography with a mixture of acetone / petroleum ether (3 : 7) as eluent. The phosphonium salt (II’c) was isolated in 70% yield. Pale yellow solid 31P NMR (121 MHz, CDCl3) : 5(ppm) = +21 (s).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; JUGE, Sylvain; BAYARDON, Jerome; REMOND, Emmanuelle; ONDEL-EYMIN, Marie-Joelle; WO2013/30193; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Complex 2: Solid AgSCN (0.0718 g, 0.43 mmol) was added to the solution of benzyldiphenylphosphine (0.2376 g, 0.86 mmol) in acetonitrile(50 cm3). The reaction mixture was heated under reflux for 5.5 h. The solution was filtered hot and the solvent was reduced to 10 cm3 by means of evaporation. The solution was left to crystallise from which small white crystals were isolated (0.2446 g,78%), mp 81-83 C. The product obtained was recrystallised from acetonitrile (5 cm3), from which large clear cubic crystals were isolated.Anal. Calc. for C39H34AgNSP2CH3CN: C, 64.83; H, 4.91; N,3.69; S, 4.22. Found: C, 64.88; H, 4.68; N, 2.35; S, 4.27%. Solid FTIR(m in cm1): 3054 (m(C-H), aromatic), w) 2950 (m(C-H) benzyl,w) 2359, 2341 (m); 2083 (m(SCN), s); 1598, 1584, 1494, 1480,1433, 1418 (m(CC), aromatic, m); 1452.34, (d(CH2), benzyl), m);1307 (m(C-H rock), benzyl, m), 1275 (w); 1096 (m(P-C), m); 1064(m); 1027, 997 (m); 917 (w); 841 (d(C-H), aromatic, m); 776 (d(C-H), aromatic, s); 743 (d(C-H), aromatic, s); 692 (d(C-H), aromatic,s). 1H NMR (400 MHz, CDCl3): d (ppm) 3.66 (d, 2J(H-P)= 6.8 Hz, CH2 benzyl, 2H); 6.99 (s, H-aromatic); 7.02 (d,3J = 6.0 Hz, H-aromatic); 7.27 (m, H-aromatic); 7.36 (t, 3J = 7.0 Hz,H-aromatic). 13C{H} NMR (100 MHz, CDCl3): d(ppm) 35.25 (d, 1J(P-C) = 8.9 Hz, CH2, benzyl); 126.73 (s, ortho C, benzyl); 128.67 (s,meta C, benzyl); 128.78 (d, 2J(P-C) = 9.1 Hz, ortho C, phenyl);129.55 (d, 3J(P-C) = 5.6 Hz, meta C, phenyl); 130.41 (s, para C, phenyl);131.67 (d, 1J(P-C) = 23.8 Hz, ipso C, phenyl); 133.15 (d, 2J(P-C)= 15.2 Hz, ipso C, benzyl); 134.69 (s, para C, benzyl). 31P{H} NMR(161 MHz, CDCl3): d (ppm) 11.14.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Potgieter, Kariska; Cronje, Marianne J.; Meijboom, Reinout; Inorganica Chimica Acta; vol. 437; (2015); p. 195 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried 10 mL screw-capped vial was charged with [(allyl)PdCl]2 (3.7 mg, 0.010 mmol),1a (0.12 g, 0.20 mmol) and toluene (1 mL) under a gentle stream of nitrogen. The vessel washeated at 140 C for 24 h followed by cooling. An aqueous solution of H2O2 (ca. 30%, a fewdrops) was added, and the mixture was stirred at room temperature for 1 h. The mixture wasfiltered through a short pad of silica gel, and the pad was washed with EtOAc. The filtrate wasevaporated, and the residue was purified by GPC to give 2a (70 mg, 93%) as a yellowish whitesolid., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Baba, Katsuaki; Masuya, Yoshihiro; Chatani, Naoto; Tobisu, Mamoru; Chemistry Letters; vol. 46; 9; (2017); p. 1296 – 1299;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-[3-(2-trifluoromethylphenyl)-1 H-1,2,4-triazol-5-yl]pyridine (80 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:n-hexane=1:3 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a white crystalline product, referred to as complex E4 (77.2% yield; 144 mg). The reaction scheme for producing the complex E4 is represented as follows: The spectrum analysis for the complex E4 is: 1H NMR (400 MHz, CDCl3, 298 K) delta 9.07 (d, J=7.9 Hz, 1H), 8.17 (d, J=2.0 Hz, 1H), 7.99 (d, J=7.7 Hz, 1H), 7.83-7.88 (m, 4H), 7.79 (d, J=7.7 Hz, 1H), 7.56-7.62 (m, 2H), 7.44-7.53 (m, 7H), 7.08-7.15 (m, 2H), 6.99 (t, J=7.1 Hz, 1H), 6.79 (dd, J=2.2, 6 Hz, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.29 (s, 9H), 19F NMR (400 MHz, CDCl3, 298 K) delta -58.2, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.35, FAB-MS m/z 815.8 M+

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To AgNO3 (0.025g, 0.15mmol) solution in MeOH (20ml) in dark and stirring condition, 1,3-bis(diphenylphosphino)propane (dppp) (0.0605g, 0.15mmol) was added and stirred for 1h. Then L (0.0368g, 0.15mmol) was added to this solution and was magnetically stirred for 2h. Light yellow solution was obtained. It was filtered and kept undisturbed for crystallisation., 19845-69-3

The synthetic route of 19845-69-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Roy, Suman; Mondal, Tapan Kumar; Layek, Animesh; Saha, Rajat; Sinha, Chittaranjan; Inorganica Chimica Acta; vol. 469; (2018); p. 523 – 535;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.

6737-42-4, 4-[Isopropyl-(7-isopropyl-3,3,6-trimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid methyl ester (Compound 67) Following general procedure O and using 7-isopropyl-5-[isopropyl-(4-trifluoromethanesulfonyloxy-phenyl)-amino]-3,3,6-trimethyl-2,3-dihydro-benzofuran (Compound 63, 0.052 g, 0. 107 mmol), triethyl amine (0.4 mL, 0.28 mmol), palladium(II)acetate (0.030 g, 0.13 mmol) and 1,3-bis(diphenylphosphino)propane (0.041 g, 0.1 mmol) in a mixture of 3 mL of methanol, 2 mL of dimethylsulfoxide and 1 mL of 1,2-dichloroethane, the title compound (0.037 g, 84%) was obtained as a brown oil. 1 H NMR (300 MHz, CDCl3): delta 7.81 (d, 2H, J=9.2 Hz), 6.59 (s, 1H), 6.40 (d, 2H, J=9.2 Hz), 4.32 (heptet, 1H, J=6.6 Hz), 4.24 (s, 2H), 3.83 (s, 3H), 3.19 (heptet, 1H, J=7.0 Hz), 2.00 (s, 3H), 1.36-1.26 (m, 15H), 0.98 (d, 3H, J=6.6 Hz).

The synthetic route of 6737-42-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, Inc.; US6093838; (2000); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

80 g (199.8 mmol in terms of sulfur trioxide) of fuming sulfuric acid containing 20% by mass of sulfur trioxide was placed in a 3-neck flask having an internal capacity of 200 ml, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line, and 27.65 g (100.07 mmol) of diphenyl(2-methylphenyl)phosphine (hereinafter referred to as a DPOTP) was added thereto for 1 hour. Further, the liquid temperature was controlled to a range of 25 C. to 30 C. After completion of the addition, the reaction was carried out at the same temperature for 2 hours. (0220) While controlling the liquid temperature to a range of 25 C. to 30 C., the reaction solution was diluted with 600 g of ion exchange water and then transferred to a separatory funnel, and 250 g of toluene and 250 g of tetrahydrofuran were added thereto, thereby acquiring an organic phase. To the organic phase was added 20 g of an aqueous 20%-by-mass sodium hydroxide solution to separate the organic phase, thereby acquire a lower phase. The lower phase was concentrated until the liquid amount reached 95 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 23.53 g of a pale yellow solid. (0221) To this acquisition was added 120 g of ion exchange water to obtain an aqueous solution, and then 24 g of an aqueous 50%-by-mass sulfuric acid solution was added dropwise thereto. Further, 70 g of toluene and 70 g of tetrahydrofuran were added thereto, followed by sufficiently mixing, thereby acquiring an organic phase. To the organic phase was added 10.52 g (103.96 mmol) of triethylamine, followed by stirring in the range of 20 C. to 30 C. for 1 hour. This liquid was concentrated until the liquid amount reached 50 g in the range of 35 C. to 70 C. and 4 kPa to 55 kPa. A precipitate formed by stirring this concentrated solution at 10 C. for 1 hour was collected by filtration by natural filtering, thereby acquiring 15.36 g of a pale yellow solid. (0222) 31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) delta: a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt as a mono-form showed a peak at -13.19, and an oxide formed by oxidation of the phosphorous atoms showed a peak at 28.73. (0223) The acquisition was a mixture including 14.63 g (31.98 mmol, 95.42% by mole) of a diphenyl(6-methyl-3-sulfonatophenyl)phosphine triethylammonium salt and 0.73 g (1.54 mmol, 4.58% by mole) of an oxide formed by oxidation of the phosphorous atoms. From the viewpoint that 15.36 g (33.52 mmol in terms of phosphorous atoms) of a desired product could be acquired using 27.65 g (100.07 mmol in terms of phosphorous atoms) of DPOTP, the yield based on phosphorous atoms was 33.5%. This phosphorous compound was referred to as a ligand K.

5931-53-3 Diphenyl(o-tolyl)phosphine 80040, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; KURARAY CO., LTD.; YOSHIKAWA, Tatsuya; TSUJI, Tomoaki; (30 pag.)US2016/46549; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, REFERENCE EXAMPLE 584 Preparation of (2S)-1-[4-({[t-butyl(dimethyl)silyl]oxy}methyl)phenyl]-2-(trifluoromethyl)pyrrolidine A suspension of [(4-bromobenzyl)oxy](t-butyl)dimethylsilane (1.0 g), (2S)-2-(trifluoromethyl)pyrrolidine (695 mg), tris(dibenzylideneacetone)palladium(0) (302 mg), 2-dicyclohexyl-phosphino-2′,6′-diisopropoxybiphenyl (308 mg) and sodium t-butoxide (638 mg) in 1,2-dimethoxyethane (50 mL) was stirred for 2 hours at 90 C. under nitrogen atmosphere. NH-silica gel and ethyl acetate were added to the reaction mixture, and the insoluble materials were removed by filtration. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (solvent: hexane/ethyl acetate=100/0 to 50/50), followed by silica gel column chromatography (solvent: hexane/ethyl acetate=90/10 to 20/80) to yield the titled compound (1.12 g, 94% yield). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.21 (d, J=8.70 Hz, 2H), 6.74 (d, J=8.70 Hz, 2H), 4.65 (s, 2H), 4.21 (m, 1H), 3.60-3.69 (m, 1H), 3.16-3.26 (m, 1H), 2.12-2.29 (m, 2H), 1.95-2.11 (m, 2H), 0.93 (s, 9H), 0.08 (s, 6H).

As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei; US2015/239889; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

[0139] Under argon atmosphere, tris(3-sulfonatophenyl)phosphine hydrate sodium salt (c) (42.6 mg, 0.075 mmol) and acetylacetonato iridium(1,5-cyclooctadiene) (10.0 mg, 0.025 mmol) were placed in a Schlenk flask. One-half milliliters of a degassed aqueous formic acid solution (98 vol %) was added thereto with a syringe, and the flask was tightly sealed, followed by stirring the resulting mixture at 60 C. for 1 hour. Thereafter, the aqueous formic acid solution was removed under reduced pressure, and the resultant was washed with ethanol, to obtain the iridium hydride complex C as white powder (46.6 mg). Spectroscopic Data of the Iridium Hydride Complex C: [0140] 1H NMR (D2O), delta: 6.97-8.00 (m, 24H), [fac: -10.64 (t, JH-P=18.4 Hz, 1H), -11.83 (ddd, JH-P=102.7, 20.4 Hz, JH-H=4.8 Hz, 2H)]

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY; Muranaka, Makoto; Oshiki, Toshiyuki; US2013/244865; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate