Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

Compound 3 was obtained while attempting to synthesize the tetrakis adduct. TFFPP (0.0800 g, 0.232 mmol) was added to a solution of [AuCl(C4H8S)] (0.0134 g, 0.058 mmol) in tetrahydrofuran (20 mL) at -80 ¡ãC and the reaction stirred for 2 h. The solvent was removed by purging nitrogen gas into the solution, until all the solvent dried up. The residue was then recrystallized from CH2Cl2/n-hexane mixture. After nine days partial evaporation of the solvent provided x-ray quality crystals. Yield is 94percent. 1H NMR [delta (ppm)]: 7.2(m) and 7.7(m). 31P NMR [delta (ppm)]: 81.1.

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Agbeworvi, George; Assefa, Zerihun; Sykora, Richard E.; Taylor, Jared; Crawford, Carlos; Journal of Molecular Structure; vol. 1108; (2016); p. 508 – 515;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 5mg (1 eq) of (CO)2Rh(SQ) and 3.6mg (1.04 eq) of PPh3 was dissolved in 5ml of toluene. The mixture was kept at room temperature until complete disappearance of initial (CO)2Rh(SQ) signal in EPR spectrum. Forming violet solution was degassed, frozen by liquid N2 and 1.1 eq of corresponding diphos was added under vacuum. The mixture was quickly brought to room temperature and placed into EPR cavity immediately. All of reactions were carried out without isolation of the products.

13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Kozhanov; Bubnov; Teplova; Abakumov; Cherkasov; Journal of Molecular Structure; vol. 1147; (2017); p. 541 – 548;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c Methyl (+-)-3-carbomethoxy-4-[2-bis(tert-butoxycarbonyl)aminomethyl-4-methoxyphenyl]-3-butenoate A 500 mL flask was charged with 3-bis(tert-butoxycarbonyl)aminomethyl-4-bromoanisole (15 g, 36 mmol), dimethyl itaconate (7.5 g, 47 mmol), tri-o-tolylphosphine (1 g, 3 mol), palladium acetate (0.4 g, 2 mmol), diisopropylethylamine (12.8 mL, 72 mmol), and propionitrile (150 mL). The mixture was purged with argon (several evacuation/argon flush cycles), then was heated to reflux under argon for 1 hr. The reaction was allowed to cool to RT, then was poured into ice-cold ethyl ether (500 mL). The resulting precipitate was removed by filtration and the filtrate was concentrated. The residue was purified by chromatography on silica gel (10% -20% ethyl acetate in hexane) to give the title compound (11.8 g, 66%) as a pale yellow oil.

6163-58-2 Tri-o-tolylphosphine 80271, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; SmithKline Beecham Corporation; US2002/32187; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 21A N-(2-Fluoro-4-nitrophenyl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 8 mg (50 mumol) of 4-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine, 9 mg (60 mumol) of 2-fluoro-4-nitroaniline, 4 mg (5 mmol) of tris(dibenzylideneacetone)dipalladium and 5 mg (10 mumol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 10 mg (70 mumol) of potassium carbonate in 1.00 ml of degassed tert-butanol is stirred at 100 C. in a sealed pressure vessel for 3 h. After cooling to RT, the mixture is filtered through Celite, the Celite is washed with methanol and the filtrates are concentrated under reduced pressure. The residue is purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 1:1). Yield: 12 mg (87% of theory) LC-MS (Method 3): Rt=1.63 nm n. MS (ESI pos.): m/z=287 (M+H)+. 1H-NMR (DMSO-d6, 300 MHz): delta=2.13 (s, 3H), 6.82-6.96 (m, 2H), 7.18 (s, 1H), 7.94 (d, 1H), 8.08-8.18 (m, 2H).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

224311-51-7, 2-(Di-tert-Butylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50 ml of degassed, anhydrous methanol were heated to reflux temperature, and 2.36 g (7.9 mmol) of 2-(di-tert-butylphosphino)biphenyl were added slowly to the methanol until the phosphine compound was completely dissolved. Subsequently, 0.59 g (2.6 mmol) of copper(II) bromide was added to the solution in portions. After the copper bromide had been added, the solution was heated to reflux temperature for a further 15 min, and then the solution was cooled. After the solution had been cooled, a solid precipitated out and was filtered off, and was washed with a little ethanol and diethyl ether and subsequently dried. 0.93 g (1.1 mmol) of the abovementioned compound was obtained. The yield was 80percent of theory.

224311-51-7 2-(Di-tert-Butylphosphino)biphenyl 2734215, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Scholz, Ulrich; Kunz, Klaus; Gaertzen, Oliver; Benet-Buchholz, Jordi; Wesener, Joachim; US2004/198997; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131274-22-1,Tri-tert-butylphosphonium tetrafluoroborate,as a common compound, the synthetic route is as follows.

Step A (2E)-3-(2-Phenyl-5-pyrimidinyl)-2-propenoic Acid Methyl Ester Dioxane (1.3 mL) was added to a mixture of 5-bromo-2-phenylpyrimidine (310 mg, 1.32 mmol, prepared as described in Org. Lett. 2002, 4, 513), tri-t-butylphosphonium tetrafluoroborate (11 mg, 0.038 mmol), and tris(dibenzylideneacetone)dipalladium(0) (18 mg, 0.020 mmol). N-Methyldicyclohexylamine (0.31 mL, 1.45 mmol) and methyl acrylate (0.24 mL, 2.67 mmol) were added and the mixture was stirred for 72 h at room temperature. The mixture was diluted with ethyl acetate, filtered through a small plug of silica gel which was washed with additional ethyl acetate, and the combined filtrates were concentrated. The residue was triturated with 5:1 hexane/ethyl acetate and the solid was filtered and dried in vacuo to provide 178 mg (56%) of the title compound as an off-white solid. MS 241 (M+H)+.

131274-22-1 Tri-tert-butylphosphonium tetrafluoroborate 2734635, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Henninger, Todd C.; Macielag, Mark J.; Tennakoon, Manomi A.; Xu, Xiaodong; US2003/220272; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexylcarboxylic acid (136 mg, 1 mmol), 4-dimethylaminopyridine (DMAP, 18.3 mg, 0.15 mmol), dicyclohexylcarbodiimide (DCC, 340 mg, 1.65 mmol), and hydrogen peroxide to the reaction flask. (57 muL 1.9 mmol) and dichloromethane (5 mL), stirred at room temperature for 2 hours, filtered, and distilled off the solvent in the filtrate to obtain a concentrate;To the concentrate were added copper bromide (17.8 mg, 0.08 mmol), 6,6′-dimethyl-2,2′-bipyridine (14.7 mg, 0.08 mmol), and ethylene glycol dimethyl ether (1 mL). And diphenylphosphine (50.5 mg, 0.25 mmol), stirred at 60 oC, TLC monitoring until the end of the reaction;The crude product obtained after the reaction was separated by column chromatography (petroleum ether: acetone = 4: 1) to obtain the target product (yield 75%).

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

To a colourless solution of [(C6F5)2Pt(mu-PPh2)2Pt(NCMe)2] (0.150g, 0.127mmol) in acetone (5mL) was added dppf (0.071g, 0.127mmol). The resulting yellow solution was stirred at room temperature for 1h and then evaporated to 2mL. Complex 1 crystallized as a yellow solid, which was filtered, washed with Et2O (2¡Á2mL) and vacuum-dried. Yield: 0.178g, 85percent. Anal. Found (Calc. for C70H48F10FeP4Pt2): C, 51.07 (50.99); H, 3.08 (2.93). IR (Nujol, cm?1): 1161 (vs), 821 (s) dppf; 952 (vs), 781(vs) (Fermi res., C6F5), 772 (vs) (X-sensitive C6F5). 1H NMR (thf-d8, 295K, 400MHz): delta 4.10 (s, CbetaH, 4H), 4.41 (s, CgammaH, 4H), from 6.5 to 8.5 (m, Ph, 40H). 19F NMR (thf-d8, 300K, 376.5MHz): delta ?116.7 (4 o-F, 3JF,Pt(1)=325Hz), ?168.8 (m, 4 m-F), ?169.6 (t, 2 p-F, 3JF,F=20Hz); 31P{1H} NMR (thf-d8, 295K, 162MHz): delta 12.0 (m, 2JP(3),P(1)=2JP(4),P(2)=239Hz, 2JP(3),P(4)=55Hz, 2JP(3),P(2)=2JP(4),P(1)=14Hz, 1JP,Pt=2210Hz, P3/4), ?98.6 (m, 2JP(1),P(3)=2JP(2),P(4)=239Hz, 2JP(1),P(2)=111Hz, 2JP(1),P(4)=2JP(2),P(3)=14Hz, 1JP,Pt(1)=1802Hz, 1JP,Pt(2)=1745Hz, P1/2) ppm. 195Pt{1H} NMR (thf-d8, 295K, 86MHz): delta ?3761 (m, Pt1), ?4235 (m, Pt2), ppm.

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Giardina-Papa, Daniela; Ara, Irene; Ibanez, Susana; Mastrorilli, Piero; Gallo, Vito; Fornies, Juan; Polyhedron; vol. 120; (2016); p. 44 – 53;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

255835-82-6, Dicyclohexyl(2′-methoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

25 mL of Schlenk tube, 76.1 mg (0.2 mmol) of 2-dicyclohexylphosphino-2′-methoxybiphenyl was added,(1,5-cyclooctadiene) chlorine2.5 g of rhodium (I) dimer (2.5% of moles of raw material), 48 mg (0.6 mmol) of lithium tert-butoxide, Gas three times, under the protection of argon by adding 1,4-dioxane 1mL, bromobenzene 47.1mg (0.3mmol). 138 C for 36 hours and cooled After cooling at room temperature, the solvent was evaporated under reduced pressure, separated by 200-300 mesh silica gel column, petroleum ether: ethyl acetate = 100: 1 elution, true Dried in vacuo to give product 59.0 mg of a pale yellow solid in 65% yield

255835-82-6 Dicyclohexyl(2′-methoxy-[1,1′-biphenyl]-2-yl)phosphine 11794186, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Nanjing University; Qiu Xiaodong; Wang Minyan; Zhao Yue; Pu Xinghui; Hu Jiefeng; Shi Zhuangzhi; (26 pag.)CN106674279; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl-2,2,4,4-tetramethyl chroman-6-carboxylate (Compound 23) A solution of 6-bromo-2,2,4,4-tetramethylchroman (synthesis is described in U.S. Pat. No. 6,252,090)(2.2 g, 8.08 mmol), palladium acetate (0.145 g, 0.65 mmol) and 1,3-bis(diphenylphosphino)propane (0.267 g, 0.65 mmol) in a mixture of N,N-dimethylformamide (25 mL), ethanol (20 mL) and triethyl amine (7 mL) was heated at 90 C. under an atmosphere of carbon monoxide overnight. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ethyl acetate. The combined organic extract was washed with brine (*1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to an oil which was subjected to flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent to afford the title compound (1.9 g, 90%). 1H NMR (300 MHz, CDCl3): delta8.00 (d, 1H, J=2.3 Hz), 7.76 (dd, 1H, J=2.1,8.5 Hz), 6.79 (d, 1H, J=8.5 Hz), 4.33(q, 2H, J=7.1 Hz), 1.85 (s, 2H), 1.36(s, 6H), 1.37 (s, 6H), 1.39-1.33(m, 3H).

As the paragraph descriping shows that 6737-42-4 is playing an increasingly important role.

Reference£º
Patent; Yuan, Yang-Dar; Vasudevan, Jayasree; Thacher, Scott; Chandraratna, Roshantha A.; US2004/77721; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate