Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.032 g,0.5 mmol) and POP (0.22 g, 0.4 mmol) reacted in CH3CN (5 mL) at60 C for 24 h. The resulting mixture was filtered through a plug ofCelite and concentrated to ca. 1 mL. Addition of Et2O (10 ml) to thefiltrate afforded a pale yellow precipitate, which was collected andwashed with Et2O. And the productwas recrystallized with ethanol., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Wang, Jinglan; Liu, Shaobo; Xu, Shengxian; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Organometallic Chemistry; vol. 846; (2017); p. 351 – 359;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

1 was labeled with99mTc by heating99mTc in a vehicle solution containing tricine and 3,3′,3″-phosphanetriyltris(benzenesulfonic acid) trisodium salt (TPPTS) in high purity and yield. Typically, 2 mug of 1 was mixed 5-10 mCi / 100 mu99iotaetaTau04, followed by addition of with 200 of the vehicle solution in a vial. The mixture was heated at 95 C for 10 min, and cooled to room temperature to yield the99mTc-labeled product as analyzed by radio- HPLC. Radio-HPLC analysis was performed using Waters RP-HPLC (Milford, MA) on a reverse-phase analytical column (Phenomenex, Jupiter 4 mu Proteo 90A, 250 x 4.6 mm, 4 micron) with a gradient from 10% to 70 % aqueous acetonitrile containing 25 mM ammonium formate at a flow rate of 1 mL/min over 40 min.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; YALE UNIVERSITY; THE UNITED STATES OF AMERICA as represented by THE DEPARTMENT OF VETERANS AFFAIRS; SADEGHI, Mehran; YE, Yunpeng; KIM, Hye-Yeong; HUANG, Henry (Yiyun); TOCZEK, Jakub; (85 pag.)WO2017/177144; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: To a solution of [Fe2(CO)6(m-SCH2CH2CH2S)] (0.039 g, 0.10 mmol) and methyl diphenylphosphinite(0.022 g, 0.10 mmol) in CH2Cl2 (5 mL) was added a solution ofMe3NO2H2O (0.011 g, 0.10 mmol) in MeCN (5 mL). The mixture was stirred at roomtemperature for 1 h and then the solvent was reduced on a rotary evaporator. Theresidue was subjected to TLC using CH2Cl2/petroleum ether 1:5 (v/v) as eluent.From the main red band, 0.045 g (78%) of 2 was obtained as a red solid. IR (CH2Cl2,cm1): mCO 2045 (vs), 1983 (vs), 1933 (m). 1H NMR (500 MHz, CDCl3): 7.78 (s, 4H, PhH),7.45 (s, 6H, PhH), 3.61 (d, J12.5 Hz, 3H, CH3), 1.88 (s, 2H, CH2), 1.63 (s, 4H, 2SCH2)ppm. 31Pf1Hg NMR (200 MHz, CDCl3, 85% H3PO4): 167.75 (s) ppm. 13Cf1Hg NMR(125 MHz, CDCl3): 213.67 (d, JP-C 13.7 Hz, PFeCO), 209.61 (s, FeCO), 139.22 (d, JP-C 42.9 Hz, i-PhC), 131.07 (d, JP-C 12.2 Hz, o-PhC), 130.73 (s, p-PhC), 128.43 (d, JP-C 9.7 Hz, m-PhC), 53.16 (s, CH3), 30.09 (s, SCH2), 22.01 (s, CH2) ppm. Anal. Calcd. forC21H19Fe2O6PS2: C, 43.93; H, 3.34. Found: C, 44.06; H, 3.52%.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yan, Lin; Hu, Meng-Yuan; Mu, Chao; Li, Ao; Liu, Xu-Feng; Zhao, Pei-Hua; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2499 – 2516;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Example 1 Diphenyl(phthalimidomethyl)phosphine oxide IV Toluene (25 ml) was added to a mixture of ethyl diphenylphosphinite (5 g, 21.71 mmole) and the N-(bromomethy)phthalimide III (5.21 g, 21.70 mmole) at room temperature. The reaction mixture was heated to 90 C. and maintained at this temperature for 48 h when the reaction was complete as indicated from the TLC of the reaction mixture. The reaction mixture was concentrated under reduced pressure, triturated with toluene and filtered to furnish the phosphine oxide compound IV as a solid; yield: 6 g, 76.5%.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; HELVETICA INDUSTRIES (P) LIMITED; US2011/263870; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

A mixture of 0.23 g (0.6 mmol) of iodo aminoester (S)-2-(t-butyloxycarbonylamino)allyl-4-iodobutanoate (III’) and 0.42 g (1.2 mmol) of [tri-(4- methoxyphenyl)]phosphine in 0.5 mL of dry THF was stirred under argon at 80C. After three hours, 3 mL of toluene followed by 30 mL of diethyl ether were added to the mixture at room temperature. The white precipitate was washed with 2 x 25 mL of diethyl ether and purified by chromatography with a mixture of acetone / petroleum ether (3 : 7) as eluent. The phosphonium salt (II’c) was isolated in 70% yield. Pale yellow solid 31P NMR (121 MHz, CDCl3) : 5(ppm) = +21 (s).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE BOURGOGNE; JUGE, Sylvain; BAYARDON, Jerome; REMOND, Emmanuelle; ONDEL-EYMIN, Marie-Joelle; WO2013/30193; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Complex 2: Solid AgSCN (0.0718 g, 0.43 mmol) was added to the solution of benzyldiphenylphosphine (0.2376 g, 0.86 mmol) in acetonitrile(50 cm3). The reaction mixture was heated under reflux for 5.5 h. The solution was filtered hot and the solvent was reduced to 10 cm3 by means of evaporation. The solution was left to crystallise from which small white crystals were isolated (0.2446 g,78%), mp 81-83 C. The product obtained was recrystallised from acetonitrile (5 cm3), from which large clear cubic crystals were isolated.Anal. Calc. for C39H34AgNSP2CH3CN: C, 64.83; H, 4.91; N,3.69; S, 4.22. Found: C, 64.88; H, 4.68; N, 2.35; S, 4.27%. Solid FTIR(m in cm1): 3054 (m(C-H), aromatic), w) 2950 (m(C-H) benzyl,w) 2359, 2341 (m); 2083 (m(SCN), s); 1598, 1584, 1494, 1480,1433, 1418 (m(CC), aromatic, m); 1452.34, (d(CH2), benzyl), m);1307 (m(C-H rock), benzyl, m), 1275 (w); 1096 (m(P-C), m); 1064(m); 1027, 997 (m); 917 (w); 841 (d(C-H), aromatic, m); 776 (d(C-H), aromatic, s); 743 (d(C-H), aromatic, s); 692 (d(C-H), aromatic,s). 1H NMR (400 MHz, CDCl3): d (ppm) 3.66 (d, 2J(H-P)= 6.8 Hz, CH2 benzyl, 2H); 6.99 (s, H-aromatic); 7.02 (d,3J = 6.0 Hz, H-aromatic); 7.27 (m, H-aromatic); 7.36 (t, 3J = 7.0 Hz,H-aromatic). 13C{H} NMR (100 MHz, CDCl3): d(ppm) 35.25 (d, 1J(P-C) = 8.9 Hz, CH2, benzyl); 126.73 (s, ortho C, benzyl); 128.67 (s,meta C, benzyl); 128.78 (d, 2J(P-C) = 9.1 Hz, ortho C, phenyl);129.55 (d, 3J(P-C) = 5.6 Hz, meta C, phenyl); 130.41 (s, para C, phenyl);131.67 (d, 1J(P-C) = 23.8 Hz, ipso C, phenyl); 133.15 (d, 2J(P-C)= 15.2 Hz, ipso C, benzyl); 134.69 (s, para C, benzyl). 31P{H} NMR(161 MHz, CDCl3): d (ppm) 11.14.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Potgieter, Kariska; Cronje, Marianne J.; Meijboom, Reinout; Inorganica Chimica Acta; vol. 437; (2015); p. 195 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried 10 mL screw-capped vial was charged with [(allyl)PdCl]2 (3.7 mg, 0.010 mmol),1a (0.12 g, 0.20 mmol) and toluene (1 mL) under a gentle stream of nitrogen. The vessel washeated at 140 C for 24 h followed by cooling. An aqueous solution of H2O2 (ca. 30%, a fewdrops) was added, and the mixture was stirred at room temperature for 1 h. The mixture wasfiltered through a short pad of silica gel, and the pad was washed with EtOAc. The filtrate wasevaporated, and the residue was purified by GPC to give 2a (70 mg, 93%) as a yellowish whitesolid., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Baba, Katsuaki; Masuya, Yoshihiro; Chatani, Naoto; Tobisu, Mamoru; Chemistry Letters; vol. 46; 9; (2017); p. 1296 – 1299;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-[3-(2-trifluoromethylphenyl)-1 H-1,2,4-triazol-5-yl]pyridine (80 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:n-hexane=1:3 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a white crystalline product, referred to as complex E4 (77.2% yield; 144 mg). The reaction scheme for producing the complex E4 is represented as follows: The spectrum analysis for the complex E4 is: 1H NMR (400 MHz, CDCl3, 298 K) delta 9.07 (d, J=7.9 Hz, 1H), 8.17 (d, J=2.0 Hz, 1H), 7.99 (d, J=7.7 Hz, 1H), 7.83-7.88 (m, 4H), 7.79 (d, J=7.7 Hz, 1H), 7.56-7.62 (m, 2H), 7.44-7.53 (m, 7H), 7.08-7.15 (m, 2H), 6.99 (t, J=7.1 Hz, 1H), 6.79 (dd, J=2.2, 6 Hz, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.29 (s, 9H), 19F NMR (400 MHz, CDCl3, 298 K) delta -58.2, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.35, FAB-MS m/z 815.8 M+

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To AgNO3 (0.025g, 0.15mmol) solution in MeOH (20ml) in dark and stirring condition, 1,3-bis(diphenylphosphino)propane (dppp) (0.0605g, 0.15mmol) was added and stirred for 1h. Then L (0.0368g, 0.15mmol) was added to this solution and was magnetically stirred for 2h. Light yellow solution was obtained. It was filtered and kept undisturbed for crystallisation., 19845-69-3

The synthetic route of 19845-69-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Roy, Suman; Mondal, Tapan Kumar; Layek, Animesh; Saha, Rajat; Sinha, Chittaranjan; Inorganica Chimica Acta; vol. 469; (2018); p. 523 – 535;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate