Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: The reactions were run in a CEM Corp. MARS microwave fitted with a fiber optic temperature probe and a port on top for a reflux condenser.1 mmol of Mo(CO)6 and dppe (0.425 g, 1.1 mmol) were combined with 20 mL of 1-propanol in a two-neck 100 mL RB flask. To this mixture was added NaBH4 (0.128 g, 3.3 mmol). The flaskwas placed in themicrowave and a reflux condenser attached through a hole in the top of the microwave. The mixture was sparged with nitrogen. The mixture was heated under nitrogen at 400 W for 1.5 min to reach reflux temperature. Once the reflux temperature was reached the microwave power was reduced and the temperature maintained for 18 min. The mixture was cooled to room temperature and 2?4 mL of water was added to the reaction to dissolve excess NaBH4 and promote product precipitation. The reaction was cooled ?10 ¡ãC for several hours. The light yellow complex was filtered in air and washed with 2¡Á5 mL of petroleum ether/diethyl ether(1:1) mixture resulting in 580 mg of Mo(CO)4dppe after drying, a 95percent yield.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Birdwhistell, Kurt R.; Schulz, Brian E.; Dizon, Paula M.; Inorganic Chemistry Communications; vol. 26; (2012); p. 69 – 71;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6163-58-2,Tri-o-tolylphosphine,as a common compound, the synthetic route is as follows.

6163-58-2, Preparation One N-(5-Vinyl-pyridin-2-yl)-acetamide. A solution of N-(5-bromo-pyridin-2-yl)-acetamide (4.30 g, 20 mmol) in acetonitrile (15 ml) and triethylamine (5.04 ml) was treated with palladium acetate (45 mg, 0.2 mmol) and tri-o-tolylphosphine (203 mg, 0.66 mmol). The mixture was placed in a pressure reactor under 50 psig of ethylene pressure and heated at 85C for 66 hours. The reaction mixture was cooled, vented, and partitioned between phosphate buffer (0.1 M, pH 6.6) and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice more. The combined ethyl acetate extracts were washed with additional phosphate buffer, brine and dried over sodium sulfate. The extracts were filtered and evaporated to afford 2.06 g (63%) of the title product as a flaky crystalline residue. Recrystallization from ethyl acetate/cyclohexane gave colorless flakes. mp 120 – 121 C 1H NMR (CDCl3): delta = 8.55 (br, 1 H); 8.24 (d, 1 H); 8.15 (d, 1 H); 7.76 (d of d, 1H); 6.64 (d of d, 1 H); 5.73 (d, 1 H); 5.28 (d, 1 H); 2.19 (s, 3 H). MS (Cl): m/z= 163 (M+H+).

The synthetic route of 6163-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Products Inc.; EP994105; (2000); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: Dpa (0.0368 g, 0.2 mmol) and POP (0.0539 g, 0.1 mmol) wereadded into the stirring solution of AgClO4 (0.0208 g, 0.1 mmol),in a mixture of CH3CN (5 ml) and H2O (5 ml) at ambient temperature.The mixture was stirred for 6 h. The insoluble residues wereremoved by filtration, and the brown filtrate was evaporatedslowly at room temperature for about four days to yield whitecrystals. Yields: 42percent., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Zhang, Yan-Ru; Cui, Yang-Zhe; Jin, Qiong-Hua; Yang, Yu-Ping; Liu, Min; Li, Zhong-Feng; Bi, Kai-Lun; Zhang, Cun-Lin; Polyhedron; vol. 122; (2017); p. 86 – 98;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A (the ratio of 2 : 1 in a hexane solution). Theaddition of compound 2 (0.63 g, 2.5 mmol) to a solution of ester 1b(1.15 g, 5 mmol) in hexane (3 mL) was accompanied by warmingup and deepening of the color. Trituration of the reaction mixtureled to the restructuring of the crystals. The reaction mixture wasallowed to stand at 20-25 C for 24 h, thus obtaining (3,5bistertbutyl4hydroxyphenyl)diphenylphosphoryl(diphenyl)ethoxyphosphoniomethyl ylide (3b) (0.95 g, 59%), m.p. 212-215 C(toluene-heptane, 4 : 1). Found (%): C, 75.35; H, 7.18; P, 9.45.C41H46O3P2. Calculated (%): C, 75.92; H, 7.09; P, 9.57. 31P NMR(CDCl3), delta: deltaP(1) 27.82 (2JP,P = 49.40 Hz, phosphine oxide), deltaP(2)50.49 (2J = 49.4 Hz, ylide). 1H NMR (CDCl3), delta: 1.30 (s, 18 H,CMe3); 1.70 (t, 3 H, CH3, 3JH,H = 7 Hz); 4.80 (q, 2 H, CH2,3JP,H = 3JH,H = 7 Hz); 4.95 (s, 1 H, OH); 6.92 (d, 2 H, C6H2,2JH,H = 2 Hz); 7.40-8.10 (m, 20 H, C6H5). The concentration ofthe toluene-heptane mother liquor gave (3,5bistertbutyl4hydroxyphenyl)bis(diphenylphosphoryl)methane (5b) (0.26 g,16.8%), m.p. 260-263 C (toluene; cf. Ref. 12: 262-264 C).1H NMR (CDCl3), delta: 1.25 (s, 18 H, CMe3); 4.72 (t, 1 H, CH,3JP,H = 12 Hz); 5.10 (s, 1 H, OH); 6.95 (s, 2 H, C6H2); 7.20-8.30(m, 20 H, C6H5)., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov; Ismagilov; Shamsutdinova; Tarakanova; Karimova; Russian Chemical Bulletin; vol. 65; 12; (2016); p. 2943 – 2947; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 12; (2016); p. 2943 – 2947,5;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dichloromethane solution of [Fe3(mu3-YTe)(CO)9] {Y = S (1), Se(2), Te(3)} (0.1 mmol) was reacted with bis-(diphenylphosphino) ferrocene (55 mg, 0.1 mmol) at room temperature under continuous stirring condition and nitrogen atmosphere for 3 h. The reaction was monitored by TLC. On completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using preparative TLC. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated a red compound, [Fe3YTe(CO)8{eta2-(PPh2)(C5H4)Fe(C5H4)(PPh2)}] {Y = S (8), Se(9), Te(10)} (Yields = 62 mg, 56percent (8), 70 mg, 61percent (9), 86 mg, 72percent (10)) along with unreacted [Fe3YTe(CO)9] and trace amount of a black product and decomposition during the work-up.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Tirkey, Vijaylakshmi; Boddhula, Rajkumar; Mishra, Sasmita; Mobin, Shaikh M.; Chatterjee, Saurav; Journal of Organometallic Chemistry; vol. 794; (2015); p. 88 – 95;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, REFERENCE EXAMPLE 1 Synthesis of o-(diphenylphosphinylmethyl)phenol In a reactor equipped with a thermometer, a stirrer and a condenser were placed 99.2 g of o-(hydroxymethyl)phenol and 400 ml of tetrahydrofuran. They were made into a uniform solution. Thereto was added 184 g of ethyldiphenylphosphinite. The resulting mixture was subjected to reaction for 3 hr with heating and stirring. The reaction mixture was cooled and the resulting white crystal precipitate was separated by filtration and then dried to obtain 180 g of o-(diphenylphosphinylmethyl)phenol. Yield: 73% Melting point: 179 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; US4621123; (1986); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 250mL round-bottomed flask equipped with magnetic stir bar and reflux condenser was charged with benzhydrazide (0.68g, 5.00mmol), 2-(diphenylphosphino)benzaldehyde (1.60g, 5.50mmol) and 150mL ethanol. The mixture was heated at boiling temperature under magnetic stirring for 12h. A white precipitate was formed, which was collected by filtration and dried in vacuum. Yield: 1.83g, 89.6%. 1H NMR (400MHz, DMSO-d6, ppm) delta 12.01 (s, 1HNH), 9.19 (d, J=3.6Hz, 1Hbenzene), 8.09 (s, 1HCH), 7.89 (d, J=5.6Hz, 2Hbenzene), 7.58 (d, J=4.8Hz, 1Hbenzene), 7.46-7.54 (m, 3Hbenzene), 7.38-7.44 (m, 7Hbenzene), 7.22 (d, J=3.2Hz, 4Hbenzene), 6.85 (t, J=4.8Hz, 1Hbenzene). Elemental analysis calcd for C26H21N2OP: H 5.18, C 76.46, N 6.86%. Found: H 5.29, C 75.39, N 6.75%. ESI-MS calcd for C26H21N2OP: 408.1391, found 409.1485 [M+H]+, 431.1318 [M+Na]+., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Zheng, Sijia; Zhao, Liang; Wei, Jianwei; He, Cheng; Liu, Guangzhou; Duan, Chunying; Inorganic Chemistry Communications; vol. 109; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (1R,5S)-(?)-cytisine (571mg, 3.00mmol) in CH3OH (10mL) was added platinum (IV) oxide hydrate (80percent Pt) (82mg, 0.30mmol) and the mixture was stirred at room temperature under a hydrogen atmosphere (balloon) for 48h. The solids were removed by filtration through Celite and the filter cake was washed with CH2Cl2/CH3OH (9:1). The filtrate was evaporated under reduced pressure to give the crude product. Purification by flash column chromatography (silica gel, CH2Cl2/CH3OH/Et3N=20:1:0.5) gave lactam 4 (314mg, 54percent) as a white solid [8b]. To a mixture of 2-diphenylphosphinobenzoic acid (76mg, 0.25mmol), N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (58mg, 0.30mmol) and hydroxybenzotriazole (41mg, 0.30mmol) in dry CH2Cl2 (5mL) under an argon atmosphere lactam 4 (63mg, 0.32mmol) was added at room temperature. The mixture was stirred at room temperature for 24h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH=50:1) to give 116mg (97percent yield) of 5 as a white solid; m.p. 194?196¡ãC. [alpha]D20=?18.2 (c 0.31, CHCl3). 1H NMR (600MHz, CDCl3, 293K): delta=7.42 (t, JH,H=7.4Hz, 1H, Har), 7.35?7.30 (m, 6H, Har), 7.29?7.28 (m, 3H, Har), 7.25 (dt, JH,H=7.7Hz, 1H, Har), 7.23?7.21 (m, 2H, Har), 7.02 (dd, JH,H=7.3, 4.0Hz, 1H, Har), 5.06 (d, JH,H=13.9Hz, 1H, 2-Heq), 4.60 (d, JH,H=13.8Hz, 1H, 4-Heq), 3.50?3.46 (m, 1H, 12-H), 3.44 (d, JH,H=12.5Hz, 1H, 6-H), 2.98 (d, JH,H=12.5Hz, 1H, 6-H), 2.81 (d, JH,H=14.0Hz, 1H, 4-Hax), 2.78 (d, JH,H=14.0Hz, 1H, 2-Hax), 2.52?2.43 (m, 2H, 9-H, 10-H), 2.22 (dq, JH,H=13.0, 3.0Hz, 1H, 11-H), 1.96?1.85 (m, 4H, 9-H, 10-H, 11-H, 13-H), 1.80 (brs, 2H, 1-H, 5-H), 1.70?1.63 (m, 1H, 13-H) ppm. 13C NMR (150.9MHz, CDCl3, 293K): delta=170.32 (Cq, C=O, lactam), 170.12 (Cq, C=O, amide), 142.65 (d, J31P,13C=32.6Hz, Cq, Car), 136.55 (d, J31P,13C=9.9Hz, Cq, Car), 136.14 (d, J31P,13C=10.1Hz, Cq, Car), 133.99 (d J31P,13C=20.3Hz, 2 CH, Car), 133.73 (CH, Car), 133.28 (d, J31P,13C=19.6Hz, 2 CH, Car), 131.67 (Cq, CCO), 129.79 (CH, Car), 128.82 (CH, Car), 128.70 (CH, Car), 128.50 (CH, Car), 128.49 (d, J31P,13C=6.5Hz, 2 CH, Car), 128.32 (d, J31P,13C=6.9Hz, 2 CH, Car), 127.52 (d, J31P,13C=7.1Hz, CH, Car), 59.53 (CH, 12-C), 51.80 (CH2, 6-C), 45.72 (CH2, 4-C), 41.63 (CH2, 2-C), 33.02 (2 CH2, 9-C, 10-C), 32.70 (CH, 1-C), 28.15 (CH, 5-C), 28.10 (CH2, 11-C), 20.16 (CH2, 13-C) ppm. 31P{1H} NMR (242.92MHz, CDCl3, 293K): delta=?12.20ppm. IR(KBr): nu=3058, 2922, 2861, 1624, 1584, 1439, 1422, 1254, 1182, 779, 692cm?1. MS (ESI): m/z=483 (100, [M+1]+), 289 (52). C30H31N2O2P (482.55): calcd. C 74.67, H 6.48, N 5.81, found C 74.58, H 6.71, N 5.89., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, A mixed solution of Compound 558-4 (10.0 g, 0.023 mol), nickel(II) chloride (1.79 g, 0.0138 mol), and benzonitrile was heated to 180 C. and stirred for 1 hour in a two neck round bottom flask (two neck r.b.f) under nitrogen. Ph2POEt (ethyl diphenylphosphinite) (8.48 g, 0.0368 mol) was slowly added dropwise to the above mixture and then stirred for 2 hours. The reaction mixture cooled to room temperature was extracted with MC (methylene chloride)/H2O and dried using MgSO4 and then filtered. After being concentrated, the resultant reaction product was separated by column chromatography (SiO2, hexane_MC=2:1). As a result, a white solid compound 571 (6.4 g, 58%) was obtained.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEESUNG MATERIAL LTD.; JANG, SO HYUN; KIM, KEE YONG; HONG, JANG MI; CHOI, JIN SEOK; CHOI, DAE HYUK; EUM, SUNG JIN; LEE, JOO DONG; (114 pag.)KR101558495; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate