Chiral phosphine ligands

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D1 (0.12 g, 0.4 mmol), copper powder (0.032 g, 0.5 mmol), and POP (0.22 g, 0.4 mmol) werereacted in CH3CN (5 mL) at 60 ¡ãC for 24 h. The resulting mixture was filtered through a plugof Celite and concentrated to 1 mL. Addition of Et2O (10 mL) to the filtrate afforded a paleyellow precipitate, which was collected, washed with Et2O, and recrystallized with ethanol.Yield: 0.29 g, 80percent. 1H NMR (400 MHz, DMSO) delta (ppm): 8.32 (s, 1H), 8.02 (t, J = 6.4 Hz, 3H), 7.53(s, 1H), 7.43?7.37 (m, 5H), 7.33 (d, J = 6.9 Hz, 5H), 7.26 (d, J = 6.7 Hz, 4H), 7.17?7.05 (m, 9H), 6.92 (s, 4H), 6.66 (s, 2H), 3.44 (s, 3H); 13C NMR (101 MHz, DMSO) delta (ppm): 157.93, 148.14,140.51, 133.66, 132.91, 132.38, 132.10, 131.80, 131.61, 131.42, 129.82, 128.73, 125.00, 124.72,123.83, 122.44, 120.47, 116.92, 112.23, 37.52; 31P NMR (162 MHz, DMSO) delta (ppm): ?8.80 (s),?143.57 (quint). HRMS (m/z, ESI+): Calcd for C45H37CuN3OP2 ([M]+) 760.1708; found 760.1723.Anal. Calcd for C45H37CuF6N3OP3 (906.25): C, 59.64; H, 4.12; N, 4.64. Found: C, 59.97; H, 4.47;N, 4.52., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Shaobo; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Coordination Chemistry; vol. 70; 4; (2017); p. 584 – 599;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Ru3(CO)10(arphos) (52.3mg, 0.051mmol) and PCy3 (14.0mg, 0.051mmol) was heated in refluxing hexane (25ml) for 1h. Completion of the reaction was monitored by TLC. The solvent was removed under reduced pressure. The reaction mixture was separated by preparative TLC (2:3 dichloromethane:hexane), affording three bands. The first band (Rf=0.76) gave the starting material Ru3(CO)10(arphos), the second band (Rf=0.57) gave the major product, characterised as Ru3(CO)9(arphos)PCy3, and the third band was only obtained in trace amounts and was not characterised. The results are as follows. Yield: 21.7mg (33.28%),

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Shawkataly, Omar Bin; Sirat, Siti Syaida; Khan, Imthyaz Ahmed; Fun, Hoong-Kun; Polyhedron; vol. 63; (2013); p. 173 – 181;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2; To 250 ml three-necked bottle were added 50 ml tetrahydrofuran and 1.1 g metallic sodium, 4.4 g chlorodiphenylphosphine. The mixture reacted at 35¡ã C. for 2.5 h so that chlorodiphenylphosphine reacted completely to form diphenylphosphine sodium, the temperature was dropped to 0¡ã C., the resulted mixture was added to 100 ml tetrahydrofuran system containing 6.3 g lithium o-chlorobenzoate and reacted for 3 h to form lithium diphenylphosphinobenzoate, and then concentrated hydrochloric acid was added to perform hydrolysis, followed by concentration, 3.1 g o-diphenylphosphinobenzoic acid was obtained, HPLC=98.9percent, yield was 50.5percent.

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; GAO, Jianxun; Luo, Junlu; Wang, Bibo; Wang, Yamin; Dong, Hongrong; Zhou, Dong; Xu, Lei; Shi, Jinbiao; US2011/77426; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting precursor P – 1 (3.8 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of colorless crystalline precipitation, filtration to obtain pure complex [(NHC – 1) Cu (POP)]+PF6-(7.2 G, 7.3 mmol), and the yield is 73percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, General procedure: Representative procedure for the preparation of rPdtoptionally substituted (Ri?), allyl)(liqand)(X) complexes: A dry Schlenk tube is charged with the ligand (4.74 mmol) and [(optionally substituted (Ri2)m- allyl)PdCI]2 (2.36 mmol). The tube is evacuated and backfilled with nitrogen a total of three times. 10 mL of anhydrous solvent (such as THF or toluene) is added and the mixture is stirred at room temperature for a period of time (e.g . 20 minutes). Pentane (5 mL) or hexanes is added to fully precipitate the product. The product is collected by vacuum filtration, washed (3 x 10 mL of pentane, or hexanes) and dried under vacuum

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5518-52-5,Tri(furan-2-yl)phosphine,as a common compound, the synthetic route is as follows.

5518-52-5, EXAMPLE 44A 1,3-dinitro-2-vinylbenzene 1-Chloro-2,6-dinitrobenzene (1.00 g, 4.94 mmoles, purchased from Lancaster) tris(dibenzylideneacetone)dipalladium (0.113 g, 0.123 mmoles), tri-2-furylphosphine (0.229 g, 0.987 mmoles), copper(I) iodide (0.094 g, 0.494 mmoles), and lithium chloride (0.628 g, 14.8 mmoles) in N,N-dimethylformamide (15 mL) were treated with tributylethenylstannane (2.90 mL, 9.87 mmoles). The reaction mixture was degassed with nitrogen, stirred overnight at room temperature and then heated at 80 C. for 4 hours. The reaction mixture was then diluted with ethyl acetate and washed with water and brine. The organic phase was dried with sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 10% ethyl acetate/hexanes) to provide the title compound (0.669 g, 70%). MS (DCI) m/z 194 (M+H)+.

5518-52-5 Tri(furan-2-yl)phosphine 521585, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Link, James T.; Sorensen, Bryan K.; Patel, Jyoti R.; Arendsen, David L.; Li, Gaoquan; US2002/156311; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

Dppf (11.36 mg, 0.0205 mmol) was added to a solution of complex [PtCl{(kappa2-P,C)P(OC6H4) (OPh)2}SMe2], 3, (25 mg, 0.041 mmol) in acetone. The solution was stirred for 3 h at room temperature. The solvent was then removed by rotary evaporator to give an orange solid which was washed with 2 mL of n-hexane. 38percent yield; mp = 254 ¡ãC. Anal. Calcd. for C70H56O6Cl2P4FePt2: C, 51.45; H, 3.45percent; Found: C, 52.28; H, 3.62percent. NMR data in CDCl3: delta(1H) = 4.65 [br s, 4H, beta Cp protons]; 4.75 [br s, 4H, alpha Cp protons]; 8.43 [br, 1H, H1 of phenyl adjacent to platinum]; other aromatic protons: 6.83-7.40; delta(31P) = 16.2 [d, 2P, 2JP(a)P(c) = 24.4 Hz, 1JPtP(a) = 1881 Hz, P of dppf]; 98.2 [d, P, 2JP(c)P(a) = 24.4 Hz, 1JPtP(c) = 6695 Hz, P of cyclometal moiety].

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Paziresh, Sareh; Aghakhanpour, Reza Babadi; Esmaeilbeig, Ahmad R.; Journal of Organometallic Chemistry; vol. 803; (2016); p. 73 – 81;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The complex RuCI2(CO)(dmf)(PPh3)2 (200 mg, 0.25 mmol, 1 equiv) dissolved in CH2CI2 (2 mL) was reacted with the ligand dppf (160 mg, 0.29 mmol, 1 .2 equiv) at room temperature for 2 h. The ligand en (15 muL, 0.37 mmol, 1.5 equiv) was then added and the mixture was stirred at room temperature for 2 h. The solution was concentrated to about 0.5 mL and the complex was precipitated by addition of n-heptane (10 mL). The obtained solid was filtered and thoroughly washed 4 times with ethyl ether (3 mL) and dried under reduced pressure. Yield: 180 mg (88percent). Anal. Calcd (percent) for C37H36CI2FeN2OP2Ru: C, 54.56; H, 4.46; N, 3.44, Found: C, 54.50; H, 4.51 ; N, 3.47. 1H NMR (200 MHz, CD2CI2) delta 7.97 – 7.24 (m, 20H), 5.59 (s, 2H), 5.15 – 4.91 (m, 2H), 4.53 (s, 2H), 4.20 (s, 2H), 3.97 (s, 2H), 3.68 – 3.42 (m, 2H), 2.58 – 2.41 (m, 2H), 2.14 – 1 .85 (m, 2H). 13C NMR (50 MHz, CD2CI2) delta 204.0 (t, J = 14.8 Hz), 135.9 (t, J = 5.7 Hz), 134.2, 134.1 (d, J = 10.1 Hz), 133.4, 132.9 (t, J = 4.7 Hz), 132.0, 130.7, 130.4 (d, J = 2.4 Hz), 129.2 – 128.3 (m), 77.8 (t, J = 4.9 Hz), 75.7 (t, J = 3.2 Hz), 73.5 (t, J = 3.3 Hz), 71 .3 (t, J = 3.0 Hz), 45.7. 31 P NMR (81 .0 MHz, CD2CI2) delta 39.8. IR (cm-1): 1960.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI UDINE; INNOVATION FACTORY S.R.L.; BARATTA, Walter; BALDINO, Salvatore; GIBOULOT, Steven; (76 pag.)WO2017/134618; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of CuI (0.019 g, 0.1 mmol) in CH3CN(5 mL)was added to a stirred solution of 2-PBI (0.020 g, 0.1 mmol)and 2-(Dpp)bp (0.034 g, 0.1 mmol) in CH2Cl2(5 mL). Themixture was stirred for 5 min, with no visible precipitation.After filtration, the filtrate was set aside for evaporation inair. Yellow block crystals of complex 3 were obtained after3 days. Yield: 35.1 mg (48.5percent, based on Cu). Anal. Calc. for3 C36H28N3P1Cu1I1:C, 59.73; H, 3.87; N, 5.81. Found (percent):C, 59.72 H, 3.84; N, 5.78. IR (KBr pellet, cm?1): 3443sh,3077vs, 3054s, 1610w, 1491m, 1443vs, 1326m, 1114w,805m, 746vs, 711vs, 522m.

13885-09-1, The synthetic route of 13885-09-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Di; Chai, Wen-Xiang; Song, Li; Transition Metal Chemistry; vol. 43; 6; (2018); p. 517 – 527;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

[Cu(CH3CN)4]ClO4 (16.3mg, 0.050mmol) was added to a mixture of pipH (7.4mg, 0.025mmol) and POP (26.9mg, 0.050mmol) in DCM under a stream of dry argon by using Schlenk techniques and a vacuum-line system at room temperature. A lemon-yellow solution was obtained quickly and then stirred for 2h at room temperature. After filtration through the absorbent cotton, layering n-hexane dropwise onto the dichloromethane filtrate carefully produced the target product as yellow crystals a few days later. The sample was obtained in an 84.4percent yield (35.8mg) after being dried using infrared dry technique. Anal. Calc. for C90H67Cl2Cu2N5O10P4 (1a) (1697.307): C, 63.64; H, 3.98; N, 4.12. Found: C, 63.55; H, 3.95; N, 4.12percent. ESI-MS (m/z) (see Fig. S2): 1500.35 [Cu2(pip)(POP)2]+ (calcd 1500.28); 898.195 [Cu(pipH)(POP)]+ (calcd 898.192); 601.093 [Cu(POP)]+ (calcd 601.091). 1H NMR (400MHz, DMSO-d6, delta, ppm) (see Fig. S3): 15.25 (s, 1H, NH), 9.06 (d, J=8.0Hz, 2H), 8.94 (s, 1H), 8.84 (s, 0.5H), 8.78 (d, J=8.0Hz, 1H), 8.47 (s, 1H), 8.37 (d, J=8.0Hz, 1H), 8.24 (s, 1H), 8.03 (s, 1H), 7.92 (s, 0.5H), 7.70 (s, 1H), 7.48?7.01 (m, 40H), 6.84?6.67 (m, 16H). 31P NMR (400MHz, DMSO-d6, delta, ppm): ?11.34, ?13.30, ?19.47. Characteristic IR spectrum (KBr, cm?1): 1094s (ClO4?)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Niu, Yan-Wen; Liu, Xia; Zhao, Ling; Guo, Ya-Meng; Li, Wen-Xin; Ma, Miao-Miao; Li, Xiu-Ling; Polyhedron; vol. 157; (2019); p. 241 – 248;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate