Chiral phosphine ligands

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Step 3: 1-(4-(1-(4-Methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]inden-4-ol 4-Bromo-1-(4-(1-(4-methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]indene (1.3 g, 3.31 mmol), 2-di-t-butylphosphino-2′,4′,6′-tri-i-propyl-1,1′-biphenyl (150 mg, 0.353 mmol), tris(dibenzylideneacetone)dipalladium(0) (170 mg, 0.186 mmol), and potassium hydroxide (270 mg, 4.81 mmol) were suspended in 1,4-dioxane (15 mL) and water (1.5 mL) under an atmosphere of nitrogen and the mixture was heated at 100 C. for 7 h. The reaction system was diluted with water and extracted with DCM. The organic phase was dried over magnesium sulfate and evaporated in vacuo. The crude product was purified via flash chromatography on silica gel (solvent gradient: 0-10% methanol in DCM) to yield 760 mg (67%) of the title compound as a yellow solid. LCMS (ESI): [M+H]+=468.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgCl (0.0286 g, 0.2 mmol) and DMF (2 ml) into the reaction flask. Stirring for 12 h, and then filtrating, the filtrate was slow evaporated at ambient temperature. 16 days later, colorless block shaped crystals were obtained. Yield: 22.5percent (0.0427 g). Anal. Calc.for (C103H95Ag2Cl2NO5P6): C, 65.14; H, 5.01; N, 0.74. Found: C,65.45; H, 4.94; N, 0.74percent. IR (cm-1, KBr pellets): 3436br, 3050m, 2924m, 2853m, 1950w, 1676vs, 1583m, 1565m, 1480s, 1461s, 146vs, 1385s, 1330m, 1311m, 1257s, 1223s, 1184m, 1161m, 1127m, 1094s, 1070s, 1026m, 997m, 878m, 801m, 747s, 696s,543w, 529w, 506s, 481m, 470m, 433w, 420w. 1H NMR (600 MHz,CDCl3): 2.90 (d, 4H, dppe), 3.48 (s, 6H, DMF), 6.76?7.28 (m, 76H,Ph), 8.02 (s, 1H, DMF). 31P {1H}NMR (243 MHz, CDCl3): 5.7 (br,dppe), 11.9 (br, d, JAg?P = 286.8 Hz, DPEphos)., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146960-90-9,1,1′-Bis(dicyclohexylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

1,1′-Bis(dicyclohexylphosphino)ferrocene (dcpf) (0.578 g, 1.0 mmol) was added to a solution of gold(I) cyanide (0.223 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture at room temperature. The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h. Slowly, the colour of the solution changed from light yellowish orange to dark yellowish orange colour. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of hexane (100 mL) to this solution led to yellow needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (0.768 g, 75 %). Anal. Calc. for C36H52N2P2Au2Fe: C, 42.19; H, 5.08; N,2.73. Found: C, 42.32; H, 5.32; N, 2.94. IR (cm-1, KBr): n 3401, 2930, 2850, 2360, 2340, 2151(CN), 1730, 1440, 1240, 1164, 1110, 1032, 868, 630, 490. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K), 4.40 (s, 4H, C5H4), 4.22 (s, 4H, C5H4), 2.71-1.22 (m, 44H, Cy). 31P{1H}: delta 41.6 (s) (Sharp). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 267 (10,727), 460 (23,595). ESI-MS (m/z): 1024.1 (M+)., 146960-90-9

146960-90-9 1,1′-Bis(dicyclohexylphosphino)ferrocene 44558250, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, c Methyl (+-)-3-carbomethoxy-4-[2-bis(tert-butoxycarbonyl)aminomethyl-4-methoxyphenyl ]-3-butenoate A 500 mL flask was charged with 3-bis(tert-butoxycarbonyl)aminomethyl-4-bromoanisole (15 g, 36 mmol), dimethyl itaconate (7.5 g, 47 mmol), tri-o-tolylphosphine (1 g, 3 mol), palladium acetate (0.4 g, 2 mmol), diisopropylethylamine (12.8 mL, 72 mmol), and propionitrile (150 mL). The mixture was purged with argon (several evacuation/argon flush cycles), then was heated to reflux under argon for 1 hr. The reaction was allowed to cool to RT, then was poured into ice-cold ethyl ether (500 mL). The resulting precipitate was removed by filtration and the filtrate was concentrated. The residue was purified by chromatography on silica gel (10% – 20% ethyl acetate in hexane) to give the title compound (11.8 g, 66%) as a pale yellow oil: 1H NMR (CDCl3) delta7.94 (s, 1 H), 7.15 (d, J =8.1 Hz, 1 H)), 6.77 (d, J=8.1 Hz, 1 H), 6.76 (s, 1 H), 4.73 (s, 2 H), 3.81 (s, 3 H), 3.79 (s, 3 H), 3.71 (s, 3 H), 3.38 (s, 2 H), 1.45 (s, 18 H).

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Heerding, Dirk; US2001/14737; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ru(acac)2(CH3CN)2 (0.100 g, 0.262 mmol) and 1,1-bis(diphenylphosphino)ferrocene (dppf) (0.145 g, 0.262 mmol) were dissolved in 40 mL of toluene and refluxed under an argon atmosphere for 8 h. After the refluxing was complete, the solvent was removed under vacuum. Slow diffusion of petroleum ether vapor into a CH2Cl2 solution of Ru(acac)2(dppf) afforded the desired yellow crystal. Yield 91percent, 0.203 g. Anal. Calcd (percent) for RuFeC44H42O4P2: C, 61.91; H, 4.96. Found: C, 61.85; H, 4.99. ESI-MS (CH3CN): m/z 854.1 [M+H]+. IR (cm-1): 3058 (m), 2922 (s), 2848 (m), 1747 (m),1573 (s), 1516 (s), 1435 (m), 1400 (m), 1261 (w), 1094 (w), 1024(w), 816 (w), 748 (m), 690 (s), 615 (w), 551 (s). 1H NMR (600 MHz, CDCl3) (delta/ppm): 7.76?7.73 (m, 4 phenyl protons);7.34?7.32 (m, 6 phenyl protons); 7.29?7.24 (m, 6 phenyl protons);7.17?7.14 (m, 4 phenyl protons); 4.82 (s, 2H, CH(acac)); 4.74, 4.35,4.32, 4.19 (four singlets, 8H, (C5H4)2Fe); 1.70 (s, 6H, CH3(acac));1.49 (s, 6H, CH3(acac)). 31P (delta/ppm): 52.45 (s).

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Gao, Li-bin; Sun, Xin-zhi; Li, Lin; Li, Jian-zhong; Polyhedron; vol. 124; (2017); p. 200 – 205;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

EXAMPLE 14 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs, 1H).

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (R, R) -cyclohexanediamine (1.26 g, 11.0 mmol), 2-diphenylphosphine benzoic acid (6.74 g), DCM (100.0 mL) were added successively under nitrogen, followed by sequential EDCI (4.22 g, 22.0 mmol) and DMAP (1.34 g, 11.0 mmol) were stirred at room temperature for 6 hours, quenched with 1 N aqueous hydrochloric acid and extracted with DCM (3 x 50.0 mL). The organic phases were combined, Dried over magnesium sulfate and spin-dried to give the indicated product Trostligand;(17.4 mL, 35percent w / w) was added at 0 ¡ã C, stirred at 0 ¡ã C for 4 hours, diluted with water (100.0 mL), and the mixture was stirred at 0 ¡ã C, The aqueous phase was extracted with DCM (3 x 50.0 mL) and the combined organic phases were dried over anhydrous magnesium sulphate and spin-dried to give the indicated product as a white solid, 4.34 g, 86percent yield.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES; SHI, YIAN; HUANG, HU; PAN, HONGJIE; CAI, YUDONG; LIU, MAO; TIAN, HUA; (24 pag.)CN104447606; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

2622-14-2, Tricyclohexylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Reactions for each substrate were run in triplicate. For substrate oxidation reactions, either 21 mg pyridine-N-oxide (220 mumol) or 27 mg of x-PVP-N-oxide (220 mumol) was added to 100 mumol of substrate in 500 muL of acetonitrile in a J-Young NMR tube and sealed in the glovebox. The reactions were taken out of the glovebox and heated at 110 C for 24 hours. After cooling to room temperature, the solvent was transferred to a clean vial and 100 muL of a 0.333 M of 2-adamantanone solution in chloroform was added as an internal standard. The solution volume was diluted to 2.0 mL with chloroform, filtered, and analyzed by GC/FID. Product peaks were identified by comparison to GC/FID chromatograms of authentic samples of the expected products, and percent conversions were determined by comparison to 2-adamantanone as a standard., 2622-14-2

Big data shows that 2622-14-2 is playing an increasingly important role.

Reference£º
Article; Bauer, Anna M.; Ramey, Erin E.; Oberle, Kjersti G.; Fata, Gretchen A.; Hutchison, Chloe D.; Turlington, Christopher R.; Tetrahedron Letters; vol. 60; 43; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (2)Compound 2 (156 mg, 0.5 mmol), diphenyl phthalic acid (184 mg, 0.6 mmol), dicyclohexylcarbodiimide (288 mg, 1.4 mmol),4-Dimethylaminopyridine (61.1 mg, 0.5 mmol) was mixed with dichloromethane (anhydrous grade).The reaction was stirred at room temperature, and monitored by TCL plate until Compound 2 disappeared, and the reaction was carried out for 12 h;The resulting product is subjected to suction filtration,Wash with saturated brine and extract three times with dichloromethane.Purified by silica gel column chromatography,The eluent used was dichloromethane and methanol (mound ratio of dichloromethane to methanol was 15:1).A brownish green solid of 195 mg was obtained.The calculated yield is 65%;

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Inner Mongolia University; Wang Jianguo; Jiang Guoyu; Zhu Wenping; (19 pag.)CN109796493; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate