Brief introduction of 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent).

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Analyzing the synthesis route of 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: A mixture of quinone monoketal (0.6 mmol), H-phosphine oxide(0.5 mmol), and catalyst (20 mol% of H2O for allylic substitution,20 mol% of Et3N for 1,6-substitution) was dissolved in toluene underN2 atmosphere, stirred at 100 C or 80 C for 12 h. Uponcompletion of the reaction, the mixture was concentrated undervacuum. Removal of the solvent under a reduced pressure gave thecrude product; pure product was obtained by passing the crudeproduct through a short silica gel column using Hexane/EtOAc(2:1-5:1) as eluent., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Xiong, Biquan; Wang, Gang; Zhou, Congshan; Liu, Yu; Yang, Chang-An; Zhang, Panliang; Tang, Kewen; Zhou, Quan; Journal of Organometallic Chemistry; vol. 885; (2019); p. 21 – 31;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Some tips on 6163-58-2

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6163-58-2,Tri-o-tolylphosphine,as a common compound, the synthetic route is as follows.

6163-58-2, (4E)-5-(3-Pyridyl)-4-penten-2-ol A mixture of 3-bromopyridine (7.50 g, 47.46 mmol), 4-penten-2-ol (4.90 g, 56.96 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (575 mg, 1.89 mmol), triethylamine (28.4 mL, 204.11 mmol) and acetonitrile (25 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (7.50 g, 81.0 %).

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Targacept, Inc.; US6492399; (2002); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 50777-76-9

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Brief introduction of 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 2-(Diphenylphosphino)benzaldehyde (0.101g, 0.346mmol) was added to methanol (15mL), followed by the addition of benzene-1,4-diamine (0.0186g, 0.172mmol). The reaction mixture was refluxed at 68¡ãC for 6h, and stirred overnight at ambient temperature to yield a yellow suspension. A light yellow powder was collected by suction filtration, washed with hexane and dried in vacuo. Yield: 0.0985g, 88percent. Melting point: 206.4?210.4¡ãC. 1H NMR (399.95MHz, CDCl3): delta (ppm)=9.06 (d, 4JHP=5.10Hz, 2H, HC=N); 8.19 (m, 2H, Hd); 7.45 (t, 3JHH=7.80Hz, 2H, Hc); 7.33 (m, 22H, PPh2 & Hb); 6.94 (m, 2H, Ha); 6.88 (s, 4H, He). 31P NMR (162.00MHz, CDCl3): delta (ppm)=?22.2. FT-IR (KBr, cm?1): nu=3435 (w, N?H); 1610 (m, C=N). MS-EI+: m/z 653 ([M]+, 40percent); 652 ([M?H]+, 94percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adams, Muneebah; De Kock, Carmen; Smith, Peter J.; Chibale, Kelly; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 736; (2013); p. 19 – 26;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Brief introduction of 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound NF-OH (50 mg, 0.16 mmol) and 2-(diphenylphosphino)benzoic acid (161.7 mg, 0.528 mmol) were dissolved in dichloromethane and then added4-(Dimethylamino)-pyridine-4-toluenesulfonate (141.3 mg, 0.48 mmol) and N,N’-diisopropylcarbodiimide (60.6 mg, 0.48 mmol). The reaction system was stirred at room temperature for 5 hours under argon gas. It is then extracted with ethyl acetate and the organic phase is separated.Drying over anhydrous sodium sulfate and column chromatography gave the product: NF-P., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Hubei University; Wang Feiyi; Yang Guichun; Chai Yun; Chen Zuxing; Lu Cuifen; Nie Junqi; Ma Chao; (12 pag.)CN109608495; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 2-methoxyphenylacetylene (0.066 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuCl (0.01 g, 0.1 mmol), di-tert-butyl peroxide(0.45 g, 3 mmol),And N-methylpyrrolidone (2 mL),70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the reaction is separated by column chromatography(Ethyl acetate: petroleum ether = 1:1) gave the desired product (yield: 73%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Simple exploration of 4559-70-0

4559-70-0, As the paragraph descriping shows that 4559-70-0 is playing an increasingly important role.

4559-70-0, Diphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of dicyclohexylcarbonyl peroxide (127 mg, 0.5 mmol), copper oxide (7.9 mg, 0.1 mmol), 3,4,7,8-tetramethyl-1,10-phenanthroline (11.8 mg, 0.05 mmol), dichloromethane (1 mL) and diphenylphosphoryl (50.5 mg, 0.25 mmol), stirred at 40 C, and monitored by TLC until the end of the reaction;The crude product obtained after the completion of the reaction was separated by column chromatography ( petroleum ether: acetone = 4:1) to give the desired product (yield: 77%).

4559-70-0, As the paragraph descriping shows that 4559-70-0 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Tao Zekun; (13 pag.)CN110229187; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Downstream synthetic route of 50777-76-9

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, In a Schlenk tube under nitrogen, 2-amino-2-deoxy-1,3,3,6-tetra-O-trimethylsilyl-alpha-d-glucopyranose7 (1?g, 2.1?mmol) and ? 2-(diphenylphosphino)benzaldehyde (621?mg, 2.1?mmol) were stirred in ? toluene (40?mL) at 60?¡ãC for 12?h. After concentration, the residue was purified by flash chromatography on silica gel, eluting with ethyl acetate/hexane, 5:1 (Rf?=?0.82). Yellow oil, 1.2?g, 77percent yield, [alpha]20D=+41.6 [alpha]D20=+41.6 (c 0.5, CHCl3); 1H NMR (600?MHz, CDCl3): delta?=?0.10, 0.18, 0.25, 0.31 (4s, 36H, 4OSi(CH3)3), 3.25 (dd, 1H, J?=?9.4, 3.2, H-2), 3.71 (dd, 1H, J?=?9.6, 8.6, H-4), 3.84?3.90 (m, 2H, H-6, H-6?), 3.99 (ddd, 1H, J?=?9.6, 3.7, 2.8, H-5), 4.41 (dd, 1H, J?=?9.4, 8.6, H-3), 4.80 (d, 1H, J?=?3.2, H-1), 7.35?7.52 (m, 13H, C6H5), 8.34?8.36 (m, 1H, C6H5), 9.19 (d, 1H, J?=?6.1, NCH). 13C NMR (150?MHz, CDCl3): delta?=?0.0, 0.2, 1.1, 1.5 (4OSi(CH3)3), 62.5 (C-6), 72.5, 72.8 (C-4, C-5), 74.6 (C-2), 77.0 (C-3), 95.4 (C-1), 127.3 (d, J?=?4.4, C6H5), 128.4, 128.7, 128.8, 129.0, 129.1, 130.6, 133,7, 133.9, 134.0, 134.1, 134.2, 134.3, (C6H5), 136.2 (d, J?=?5,6, C6H5), 136.7 (d, J?=?9.9, C6H5), 138.0 (d, J?=?18.8, C6H5), 139.7 (d, J?=?17.8, C6H5), 161.1 (d, J?=?27.5, NCH). C37H58NO5PSi4 (740.18): calcd C 60.04, H 7.90, N 1.89; found C 60.01, H 7.86, N 1.96.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Olszewska, Beata; Szulc, Izabela; Kryczka, Boguslaw; Kubiak, Agnieszka; Porwanski, Stanislaw; Zawisza, Anna; Tetrahedron Asymmetry; vol. 24; 4; (2013); p. 212 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

Simple exploration of 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solutions of a (0.0256 g, 0.1 mmol)ofH2dz in 10 cm3 of methanol, (0.1 mmol, 0.0273 g)of NiCl2.6H2O in 10 cm3 of methanol) and (0.0554 g,0.1mmol of 1,1′-bis(diphenyl phosphine) ferrocene(dppf) were mixed and refluxed at 55oC for 2 h togive red-brown colored precipitate and the solutionswas filtered and finally it was dried in an open air.Yield= 72percent, d.p= 265¡ãC. Anal. Calc. percent for C47 H41 ClN4 P2 Ni S Fe: C, 62.32; H, 4.56; N, 6.19, S, 3.54, Ni,6.48, Cl,3,91 . Found percent: C, 61.83.7; H, 4.72; N, 5.94, S; 2.89,Ni; 6.93, Cl, 3.98. The Proposed GeometricalStructure shown in Figure 1., 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Mohamad, Hikmat Ali; Oriental Journal of Chemistry; vol. 34; 4; (2018); p. 1919 – 1925;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate