Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.25 methyl 2-phenyl-5-(4-fluorophenyl)thiazole-4-carboxylate (4e) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 118 mg (76percent). White solid, mp 126-128 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.86 (s, 3H), 7.13 (t, J=8.6 Hz, 2H), 7.44-7.47 (m, 3H), 7.50-7.56 (m, 2H), 7.94-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 166.1, 165.0, 162.5, 161.7, 145.3, 140.9, 132.6, 131.9, 131.8, 130.7, 129.0, 126.8, 126.3, 126.2, 115.5, 115.3, 52.3 ppm; IR (KBr) 2944, 1721, 1528, 1468, 1343, 1224, 1200, 1007, 843, 762, 689 cm-1; HRMS (ESI) calcd for [C17H12FNO2S+H]+ 314.0646, found 314.0649.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

29949-84-6, Tris(3-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 81 7-(3Methoxyphenyl)-1-(4-methylpiperazin-1-yl)naphthalene A mixture of 3-methoxy-1-bromobenzene (0.089 ml, 0.71 mmol), 7-trimethylstannyl-1-(4-methylpiperazin-1-yl)naphthalene (0.25 g, 0.64 mmol), bis-(acetonitrile) palladium chloride (0.0085 g, 0.032 mmol), tri(3-methoxyphenyl)phosphine (0.023 g, 0.064 mmol), and butylated hydroxytoluene (BHT, about 0.001 g, antioxidant) in dimethyl formamide (12 mL) was warned to 110 C. for 2 hours. The reaction was cooled to room temperature and diluted with 1 N aqueous lithium chloride (25 mL) and 1 N sodium hydroxide (2 mL); then extracted with ether (3*). The combined ether layer was washed with 1 N aqueous lithium chloride and brine. The organic phase was dried over calcium sulfate and concentrated. The residue was purified by flash chromatography on silica gel (1*2.5 inches). Elution proceeded as follows: 75% ethyl acetate/hexane, 200 mL, nil; 2% methanol/ethyl acetate 200 mL and 10% methanol/ethyl acetate, 200 mL, 0.084 g of an oil. This oil was further purified by kugelrohr distillation (1 mm Hg). The distillation proceeded as follows: 110-130 C., 0.014 g of a mixture of the title product and 7-methyl-1-(4-methylpiperazin-1-yl)naphthalene: 200-220 C. 0.062 g (23%) of the title compound as a yellow oil: 1H NMR delta 8.43 (incompletely resolved dd, J=1.2Hz, 1 h), 7.90 (d, J=9 Hz, 1 H), 7.74 (dd, J=2,8.5 Hz, 1 H), 7.58 (d, J=8 Hz, 1 H), 7.43 (sym m, 2 H), 7.34 (dt, J=1.5, 7.5 Hz, 1 H), 7.29 (5, J=2 Hz, 1 H), 7.14 (dd, J=1, 7.5 Hz, 1 H), 6.96 (ddd, J=1, 2.5,8 Hz, 1H), 3.92 (s, 3 H) 3.20 (br s, 4 H), 2.75 (br s, 4 H), 2.44 (s, 3 H). The product was dissolved in chloroform and HCL gas was bubbled through the solution to form the hydrochloride salt. Concentration of this solution to about 1 mL. at the boil and addition of about 1 mL of ether caused the white crystalline product to precipitate. The hydrochloride salt weighted 0.057 g: mp 236-238 C. Analysis calculated for C22H24N2O¡¤HCl: C, 71.63; H, 6.83; N, 7.59. Found: C, 71.31; H, 6.92; N, 7.59.

29949-84-6, The synthetic route of 29949-84-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chenard, Bertrand L.; Macor, John E.; Segelstein, Barbara E.; US2001/4669; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, Take a dry 10L three-neck reaction flask, dry nitrogen is fully replaced and under nitrogen flow protection,Add 5.5 L of anhydrous tetrahydrofuran, stir and add 540 g of bis(acetonitrile)palladium dichloride.The obtained ligand di-tert-butyl-4-dimethylaminophenylphosphine was further reacted for 30 minutes, and a yellow solid was precipitated. After the reaction was continued for 9 hours at room temperature,After filtration, the filter cake was dipped in anhydrous tetrahydrofuran, drained and dried in a vacuum oven at 60 C.Obtaining a yellow crystalline powdery target product, namely dichlorodi-tert-butyl-(4-dimethylaminophenyl)phosphine palladium, yielding 1440 g to 1445 g,Elemental analysis showed that the product content exceeded 98.0%, the palladium content exceeded 15.0%, and the palladium calculated yield was 97.7% to 98.1%.

As the paragraph descriping shows that 932710-63-9 is playing an increasingly important role.

Reference£º
Patent; Shanxi Ruike New Materials Co., Ltd.; Zhang Wen; Zhao Lei; Hou Yunji; Cai Wanyu; (11 pag.)CN108659054; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

2-Chloromethyl-3-hydroxypyridine hydrochloride (4) (0.40 g, 2.22 mmol) was added to a solution of tris- (2-thienyl)phosphine (0.93 g, 3.32 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 12 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloroform and washed with water. The aqueous layer was separated, dried in vacuo, and recrystallized from acetone. The yield was 0.24 g (24%), a white crystalline compound, m.p. 197-198 C. 1H NMR (DMSO-d6), d: 5.29 (d, 2 H, CH2P, J = 14.4 Hz); 7.22 (ABX-system, 1 H, 5-PyH, J1 = 8.0 Hz, J2= 4.6 Hz); 7.34 (ABX- system, 1 H, 4-PyH, J = 8.0 Hz); 7.49 (m, 3 H, P(2-thien)3 (thien means thienyl)); 7.91 (ABX-system, 1 H, 6-PyH, J = = 4.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1 = 8.3 Hz, J2 = 3.4 Hz); 8.45 (t, 3 H, P(2-thien)3, J = 4.6 Hz); 10.83 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 32.92 (d, CH2P, J = 64.3 Hz); 120.00 (d, Cthien, J = 112.2 Hz); 122.70 (s, CPyr); 124.62 (s, CPyr); 129.99 (d, Cthien, J = 16.2 Hz); 137.83 (d, Cthien, J = 3.9 Hz); 138.53 (s, CPyr); 140.51 (d, Cthien, J = 4.1 Hz); 141.98 (d, CPyr, J = 12.1 Hz); 152.36 (d, CPyr, J = 8.0 Hz). 31P NMR (DMSO-d6), d: 10.68. HRMS, found: m/z 388.0048 [M – 2 Cl – H]+. C18H16NOPS3Cl2. Calculated: [M – 2 Cl – H] = 388.0048., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the dimeric complex [Pd(mu-Cl)(Cl)(NHC)]2(0.10 mmol) and the appropriate diphosphine ligand (0.10 mmol) was dissolved in CH2Cl2 (5.0 mL) and stirred at ambient temperature overnight. The reaction mixture was filtered over Celite, the solvent was reduced under vacuum to about 1.0 mL and the yellow precipitate formed by careful addition of n-hexane (c.a. 10 mL). The yellow solid was then filtered off, washed with n-hexane, and dried under vacuum.

19845-69-3, As the paragraph descriping shows that 19845-69-3 is playing an increasingly important role.

Reference£º
Article; Yang, Jin; Li, Pinhua; Zhang, Yicheng; Wang, Lei; Journal of Organometallic Chemistry; vol. 766; (2014); p. 73 – 78;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of quinone monoketal (0.6 mmol), H-phosphine oxide(0.5 mmol), and catalyst (20 mol% of H2O for allylic substitution,20 mol% of Et3N for 1,6-substitution) was dissolved in toluene underN2 atmosphere, stirred at 100 C or 80 C for 12 h. Uponcompletion of the reaction, the mixture was concentrated undervacuum. Removal of the solvent under a reduced pressure gave thecrude product; pure product was obtained by passing the crudeproduct through a short silica gel column using Hexane/EtOAc(2:1-5:1) as eluent., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiong, Biquan; Wang, Gang; Zhou, Congshan; Liu, Yu; Yang, Chang-An; Zhang, Panliang; Tang, Kewen; Zhou, Quan; Journal of Organometallic Chemistry; vol. 885; (2019); p. 21 – 31;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

The terminating ligand dpepo was obtained by oxidizing the precursor DPEphos (diepiii phosph) with hydrogen peroxide., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; HOKKAIDO UNIVERSITY; STANLEY ELECTRIC COMPANY LIMITED; OSAKA PREFECTURE UNIVERSITY; HASEGAWA, YASUCHIKA; NATORI, SHIORI; NAKANISHI, TAKAYUKI; KITAGAWA, YUICHI; FUSHIMI, KOJI; AKAGI, TSUTOMU; NAITO, HIROYOSHI; FUKUDOME, JUN; (32 pag.)JP2018/35101; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

19845-69-3, 1,6-Bis(diphenylphosphino)hexane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dppb (59.4mg, 97%, 0.15mmol) was added to a DCM solution (10mL) of (C14H9C?CAu)n (119.4mg, 0.30mmol) with stirring at room temperature, then the solution was kept stirring for 1h. After filtration, addition of ethyl ether to the concentrated solution gave the product as brown powder (yield 100.8mg, 55%).

19845-69-3, 19845-69-3 1,6-Bis(diphenylphosphino)hexane 2754312, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Chen, Jing; Huang, Miao-Miao; Shi, Yanhui; Li, Xiu-Ling; Journal of Organometallic Chemistry; vol. 834; (2017); p. 58 – 63;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tri(4-fluorophenyl)phosphine: 1H-1,2,4-triazole: potassium carbonate: copper iodide molar ratio of 3: 15: 30: 1. Into a 50 mL three-neck round bottom flask equipped with magnetic stirrer, reflux condenser and thermometer, were charged tri(4-fluorophenyl)phosphine (3 mmol), 1H-1,2,4-triazole (1.035 g, 15 mmol), potassium carbonate (4.14 g, 30 mmol), CuI (0.191 g, 1 mmol), 20 mL DMF, stirred at 100 deg. C for 12 hours. After completion of the reaction, the reaction solution was cooled to room temperature, filtered, the filtrate was added with 100 mL of water, precipitation, filtration, collecting filter cake, yield 66percent.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tianjin Normal University; Wang, Ying; (6 pag.)CN104370965; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate