Chiral phosphine ligands

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Example 526 29 mg of 3,5-difluorophenol, 79 mg of tripotassium phosphate, 4.7 mg of 2-(di-tert-butylphosphino)-2′,4′,6′-triisopropylbiphenyl and 6.8 mg of tris(dibenzylideneacetone)dipalladium(0) were added to 1.4 mL of toluene solution containing 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 3 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 10:1] to obtain 71 mg of tert-butyl 2-(benzamido)-4-(3,5-difluorophenoxy)benzoate as colorless oil. 1H-NMR (CDCl3) delta: 1.64 (9H, s), 6.56-6.63 (3H, m), 6.73 (1H, dd, J = 8.8, 2.4 Hz), 7.50-7.60 (3H, m), 8.01-8.07 (3H, m), 8.70 (1H, d, J = 2.4 Hz), 12.34 (1H, s).

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, A mixture of Fe2(l-pdt)(CO)6 (0.097 g, 0.25 mmol), Ph2P(CH2Ph) (0.083 g, 0.3 mmol) and Me3NO2H2O (0.034 g, 0.3 mmol) was dissolved in MeCN (15 mL). The mixture was stirred at room temperature for 0.5 h to give a brown-red solution. The solvent was removed on a rotary evaporator and the residue was subject to preparative TLC separationusing CH2Cl2/petroleum ether (v/v1:5) as eluent. From the main red band, 1(0.076 g, 48%) was obtained as a red solid. Anal. Calcd for C27H23Fe2O5PS2: C, 51.13; H,3.66%. Found: C, 50.95; H, 3.87%. FT-IR (KBr disk, cm-1): mCO 2041 (vs.), 1979 (vs.),1954 (s), 1922 (m). 1H NMR (600 MHz, CDCl3, TMS, ppm): 7.68 (s, 4H, 2xPPhH-o), 7.44 (s,6H, 2xPPhH-m,p), 7.17 (s, 1H, CH2PhH-p), 7.11 (s, 2H, CH2PhH-o), 6.71 (s, 2H, CH2PhHm),3.87 (s, 2H, CH2Ph), 1.86 (s, 2H, 2xSCHeHa), 1.65-1.51 (m, 2xSCHeHa and CH2).31P{1H} NMR (243 MHz, CDCl3, 85% H3PO4, ppm): 63.14 (s).

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Zhao, Pei-Hua; Ma, Zhong-Yi; Hu, Meng-Yuan; Jing, Xing-Bin; Wang, Yan-Hong; Liu, Xu-Feng; Journal of Coordination Chemistry; vol. 71; 16-18; (2018); p. 2941 – 2952;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgOTf (0.0513 g, 0.2 mmol) into the reaction flask. After stirring for 18 h and then filtrating, the filtrate was slow evaporated at ambient temperature. 8 days later, colorless block-shaped crystals were obtained. Yield: 39.2percent (0.0935 g). Anal. Calc. for(C63H52AgF3O4P4S): C, 63.38; H, 4.36; N, 0. Found: C, 63.26; H,4.32; N, 0percent. IR (cm-1, KBr pellets): 3467br, 3055m, 1968w,1660m, 1587m, 1564m, 1482s, 1461s, 1435vs, 1280vs, 1253vs,1223s, 1160s, 1097s, 1069m, 1029vs, 999m, 877w, 798m, 746s,724m, 694vs, 636s, 572w, 512s, 473m, 448w, 421w. 1H NMR(600 MHz, CDCl3): 2.90 (d, 4H, dppe), 6.66?7.28 (m, 48H, Ph). 31P{1H} NMR (243 MHz, CD3Cl): 5.1 (br, d, JAg?P = 364.5 Hz, dppe),5.3 (dt, J19F?P = 211.4 Hz, dppe), 10.1 (2d, J19F?P = 102.1 Hz, DPEphos),11.3 (2d, J19F?P = 116.7 Hz, DPEphos), 11.5 (dd, J109Ag?P = 245.4 Hz,J107Ag?P = 235.7 Hz, DPEphos)., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 2-dimethylamino-2′-(diphenylphosphino)biphenyl (34.3 mg, 0.0899 mmol) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (17.5 mg, 0.0899 mmol) in dry dichloromethane, and the mixture was heated to reflux with stirring for one hour. Then, 2,9-di-n-butyl-1,10-phenanthroline (26.3 mg, 0.0899 mmol) was added to the obtained solution, which was heated to reflux for additional one and half hours. The reaction solution was filtrated, and the filtrate was concentrated and then the residue was dissolved in chloroform followed by slow diffusion of diethylether. The pale yellow precipitate was filtrated, and the filtrated matter was subjected to vacuum drying, thereby providing 45.0 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (1).

240417-00-9, The synthetic route of 240417-00-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

32.6mg mesityl -Cu and 3ml of toluene were added to 34.6mg (0.18mmol) of 8-PyQ and 79.5mg (0.18 mmol) of dppb in a glove box. It forms a dark Redsolution. This was filtered and coated with n-hexane layer. it forms redcrystals. under UV (356nm), they emit a strong red. the solution in the sameway emits a strong red. Yield: 70%.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 330 g (7.17 mol) of absolute ethanol are cooled to -15 C. under a nitrogen atmosphere. 26.5 g (1.56 mol) of ammonia gas are introduced thereto at this temperature with constant stirring. 200 g (0.907 mol) of chloro(diphenyl)-phosphine are then added dropwise at this temperature. The mixture is then allowed to come to room temperature with stirring and is then kept under reflux for 11 hours until virtually no more ammonia gas escapes. The mixture is then cooled, filtered by suction, washed with ethanol and dried. 48 g of crude ammonium chloride are obtained. The filtrate is freed from ethanol and any ammonia present in vacuo. The remaining residue is freed from a slight salt precipitate by filtration through a glass frit. 170 g of ethyl diphenylphosphinite are then obtained by thin film distillation at a bath temperature of 160 to 175 C. and a pressure of 0.5 mbar. This corresponds to a yield of 82% of theory., 1079-66-9

As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5705669; (1998); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

564483-18-7, Example 430 Production of N-{3-[(2-anilinoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide A mixture of N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (100 mg, 0.242 mmol), iodobenzene (32 mul, 0.290 mmol), tris(dibenzylideneacetone)dipalladium (0) (11 mg, 24.2 mumol), dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (23 mg, 48.4 mumol), sodium tert-butoxide (34 mg, 0.362 mmol) and toluene (2 mL) was stirred under an argon atmosphere with heating at 80 C. for 5 hr. After the reaction mixture was allowed to cool to room temperature, saturated aqueous sodium hydrogencarbonate solution was added to the mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=0/100?50/50) to give the title compound (19 mg, 16%) as a pale-green powder. 1H-NMR (DMSO-d6, 300 MHz) delta 6.78 (1H, t, J=7.3 Hz), 6.96-7.07 (2H, m), 7.18-7.25 (2H, m), 7.36-7.50 (3H, m), 7.65-7.72 (3H, m), 7.79 (1H, t, J=7.6 Hz), 7.98 (2H, d, J=9.2 Hz), 8.18-8.32 (2H, m), 8.91 (1H, s), 10.58 (1H, s).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.6 (1R,2S)-2-(4-Nitrobenzamido)-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9b fx15 Purified by flash column chromatography (50/50, hexanes/ EtOAc) to yield 0.300 g (43percent) of product as a yellow oil. [alpha]D23 = -18.9 (c, 1.04 CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.94 (d, J = 7.0 Hz, 3H), 4.61-4.68 (m, 1H), 6.29 (d, J = 2.8 Hz, 1H), 7.06-7.09 (m, 1H), 7.19-7.23 (m, 4H), 7.30-7.38 (m, 11H), 7.43-7.50 (m, 3 H), 7.99 (d, J = 8.8 Hz, 2 H), 8.05-8.08 (m, 1H), 8.18 (d, J = 8.8 Hz, 2H). 13C NMR (100 MHz, CDCl3): delta 13.95, 50.41, 79.33, 123.66, 126.10, 128.13, 128.49, 128.52, 128.59, 128.68, 128.75, 128.89, 129.08, 129.17, 130.78, 130.82, 132.42, 133.28, 133.46, 133.76, 133.96, 134.10, 135.11, 135.43, 135.66, 136.75, 136.81, 136.90, 137.15, 138.26, 138.48, 140.25, 149.43, 164.88, 167.33. 31P NMR (162 MHz, CDCl3): delta -5.39. IR v (cm-1, neat): 3068, 2982, 1717, 1660, 1524, 1346, 1250, 729, 698. ESI HRMS for C35H29N2O5P: calcd (M+H) 589.1892, found 589.1901.

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate