Chiral phosphine ligands

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, [Step 4] tert-Butyl 8-[(3S)-3,4-dimethylpiperazin-1-yl]-7,10-dimethyl-5-oxo-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate A suspension of tert-butyl 7,10-dimethyl-5-oxo-8-{[(trifluoromethyl) sulfonyl]oxy}-1,5-dihydro-2H-chromeno[3,4-c]pyridine-3(4H)-carboxylate (1.063 g), cesium carbonate (2.2 g), chloro-(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl] palladium (II)-methyl-t-butyl ether adduct (91 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl (52 mg), and (2S)-1,2-dimethylpiperazine (510 mg) in toluene (30 ml) was stirred while heating in a nitrogen atmosphere at 110 C. for 2.5 hours. The reaction solution was diluted with chloroform and a small volume of methanol and an insoluble solid was filtered off and the mother liquid was concentrated. The residue was purified by silica gel column chromatography (4-8% methanol/chloroform) to obtain the title compound (710 mg) as a solid. 1H-NMR (CDCl3) delta: 1.13 (3H, d, J=6.1 Hz), 1.50 (9H, s), 2.29-2.40 (1H, m), 2.33 (3H, s), 2.37 (3H, s), 2.46-2.62 (2H, m), 2.66 (3H, s), 2.87-2.98 (2H, m), 2.99-3.14 (4H, m), 3.58-3.65 (2H, m), 4.40 (2H, s), 6.70 (1H, s). MS (ESI/APCI) m/z: 442 [M+H]+

As the paragraph descriping shows that 787618-22-8 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; Ota, Masahiro; Inoue, Hidekazu; Kawai, Junya; Ohki, Hitoshi; Toki, Tadashi; (25 pag.)US2019/284198; (2019); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,1′-Bis(diphenylphosphino)ferrocene (dppf) (0.554 g, 1.0 mmol) was added to a solution of silver(I) cyanide (0.134 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture in dark at room temperature.The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h. Slowly, the colour of the solution changed from light orange to dark yellowish orange. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of cyclohexane (250 mL) to this solution led to yellowish orange needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (1.116 g, 70 percent).Anal. Calc. for C77H68N3P4Ag3Fe2: C, 57.97; H, 4.27; N, 2.63. Found: C, 58.12; H, 4.45; N, 2.68. IR (cm-1, KBr): nu = 3440, 3052, 2926, 2136(CN), 1958, 1892, 1650, 1581, 1478, 1430, 1310, 1165, 1158, 1094, 1087, 1030, 898, 818, 742, 696, 630, 495. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K): 8.05e7.30 (m, 40H, Ph), 4.32(s, 8H, C5H4), 4.20 (s, 8H, C5H4). 31P{1H}: d 2.56 (sbr). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 266 (10,548), 460 (24,204). ESI-MS (m/z) :1594.1 (M+).

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

The resulting precursor P – 3 (4.8 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of light yellow crystalline precipitation, filtration to obtain pure complex [(NHC – 3) Cu (POP)]+PF6-(8.1 G, 7.5 mmol), yield is 75percent., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A benzene solution (20mL) of 1 (50mg, 0.074mmol) and dppb (33mg, 0.074mmol) was refluxed for 5h. The solvent was removed under reduced pressure and the residue was chromatographed by TLC on silica gel. Elution with n-hexane/CH2Cl2 (7:3 v/v) developed two bands in addition to intractable, presumably decomposed, material. The faster moving band gave [ Fe4(CO)10 (mu3-Te)4 (kappa2-dppb)] (8) (13mg, 12%) as black crystals and the second band afforded [Fe3(CO)8(mu3-Te)2(kappa2-dppb)] (4) (20mg, 25%) as red crystals after recrystallization from hexane/CH2Cl2 at 4C. Characterization data for 4: IR (nu(CO), CH2Cl2): 2042s, 2021s, 1998vs, 1964s cm-1. 1H NMR (CDCl3): delta 7.70-7.67 (m, 4H), 7.59-7.34 (m, 10H), 7.24-7.03 (m, 10H). 31P{1H} NMR (CDCl3): delta 74.2 (s). ESI-MS: m/z 1093.24 (M+, calc. 1093.27). Characterization data for 8: IR (nu(CO), CH2Cl2): 2053s, 2029vs, 1977s, 1908w cm-1. 1H NMR (CDCl3): delta 7.67-7.04 (m, 24H). 31P{1H} NMR (CDCl3): delta 53.5 (s). ESI-MS: m/z 1460.33 (M+, calc.1460.34).

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Rahaman, Ahibur; Lisensky, George C.; Tocher, Derek A.; Richmond, Michael G.; Hogarth, Graeme; Nordlander, Ebbe; Journal of Organometallic Chemistry; vol. 867; (2018); p. 381 – 390;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-18-7, Example 412 55 mg of 2-nitroaniline, 0.17 g of cesium carbonate, 2.4 mg of tris(dibenzylideneacetone)dipalladium(0), 1.2 mg of palladium acetate and 6.3 mg of 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl were added to 2.0 mL of toluene solution containing 0.10 g of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 4 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added and insoluble were removed by filtration. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane: ethyl acetate = 1:1] to obtain 94 mg of tert-butyl 2-(benzamido)-4-(2-nitroanilino)benzoate as yellow solid. 1H-NMR (CDCl3) delta: 1.64 (9H, s), 6.90-6.96 (2H, m), 7.50-7.60 (4H, m), 7.66 (1H, dd, J = 8.5, 1.2 Hz), 8.02 (1H, d, J = 8.5 Hz), 8.02-8.08 (2H, m), 8.22 (1H, dd, J = 8.7, 1.6 Hz), 8.94 (1H, d, J = 2.2 Hz), 9.53 (1H, s), 12.33 (1H, s).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1079-66-9,Chlorodiphenylphosphine,as a common compound, the synthetic route is as follows.

To an ice-cold solution of methyl alcohol (6 mL, 1.2 mmol) in toluene (13 mL), a solution of chlorodiphenylphosphine (0.25 mL, 1.38 mmol) in toluene (3 mL) was added dropwise. After 40 min stirring, azide 5 (440 mg, 1.2 mmol) was added as a solid. The obtained mixture was heated at 60 C for 40 min and then kept at room temperature for 12 h. The collected precipitate was analytically pure product 6 (300 mg, 48%). Crystals suitable for X-ray diffraction were obtained by crystallization from MeCN-DMF (3 : 1). M.p. 245 C. Found (%): P, 5.66. C27H21BrN3O2. Calculated (%): P, 5.70. IR (KBr), nu/cm-1: 1706 (C=O), 1606 (C=N), 3346 (NH). 31P NMR (DMSO-d6), delta: 23.45. 1H NMR (DMSO-d6), delta: 4.72-4.76 (m, 1 H, CHNP); 6.43-7.97 (m, 8 H, Ar); 11.01 (s, 1 H, NH).

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Gololobov, Yu. G.; Krasnova, I. Yu.; Barabanov; Fedyanin; Andronati; Pavlovskii; Russian Chemical Bulletin; vol. 64; 1; (2015); p. 233 – 236; Izv. Akad. Nauk, Ser. Khim.; 1; (2015); p. 233 – 236,4;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

247940-06-3, 2-(Dicyclohexylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 32A 3′-ethoxy-6-methyl(1,1′-biphenyl)-3-carbonitrile A mixture of 3-chloro-4-methylbenzonitrile (3.03 g, 20 mmol), 3-ethoxyphenylboronic acid (4.98 g, 30 mmol), palladium acetate (74 mg, 0.4 mmol), 2-dicyclohexylphosphanyl-biphenyl (0.210g, 0.6 mmol), and KF (3.48g, 60 mmol) in THF (25 mL) at room temperature was stirred for 12 hours and concentrated. The concentrate was dissolved in ethyl acetate (10 mL), washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 4:100 ethyl acetate/hexanes to provide 4.68 g (99%) of the desired product. MS (DCI/NH3) m/z 255 (M+NH4)+; 1H NMR (CDCl3) delta7.54-7.51 (m, 2H), 7.36-7.31 (m, 2H), 6.93 (m, 1H), 6.85-6.78 (m, 2H), 4.07 (q, 2H), 2.32 (s, 3H), 1.34 (t, 3H).

247940-06-3, As the paragraph descriping shows that 247940-06-3 is playing an increasingly important role.

Reference£º
Patent; Claiborne, Akiyo K.; Gwaltney II, Stephen L.; Hasvold, Lisa A.; Li, Qun; Li, Tongmei; Lin, Nan-Horng; Mantei, Robert A.; Rockway, Todd W.; Sham, Hing L.; Sullivan, Gerard M.; Tong, Yunsong; Wang, Gary; Wang, Le; Wang, Xilu; Wang, Wei-Bo; US2003/87940; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, mixing dimethyl sulfide gold chloride with a phosphine ligand BrettPhos in dichloromethane, stirring the reaction for 5 min at room temperature, filtering, and spinning, That is, the BrettPhosAuCl catalyst is obtained, and the ratio of the phosphine ligands BrettPhos, dimethyl sulfide, gold chloride, and dichloromethane is 1 mmol: 1 mmol: 1 mL;

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanyang Normal College; Li Ting; Li Bo; Yang Yuhan; Yang Ping; (9 pag.)CN109053654; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, In a test cylinder containing a coolant, the molecular sieve 4 is activated. The solution of L(+)-leucine (65.5 mg, 0.5 mmol, 1 eq.) and potassium hydroxide (28 mg, 0.5 mmol, 1 eq.) in degassed anhydrous methanol (2 mL per mmol) is added. Orthodiphenylphosphine-benzaldehyde (145 mg, 0.5 mmol, 1 eq.) is then added and the mixture is kept under vigorous agitation for 3 hours at 40¡ã C. The solvent is then evaporated. The potassium iso-leucine phosphinoazomethinylate (Ib-K) is obtained in the form of a yellowish solid (209 mg, 95percent). The RMN characteristics of this compound are as follows:RMN 1H: (400 MHz, CD3DO) delta (ppm): 8.88 (d, H,PJ=5.5 Hz, 1H, H1); 8.06-8.02 (m, 1H, H9); 7.28-7.07 (m, 12H, H7, H8, H10-19); 6.72-6.69 (m, 1H, H5); 3.70 (dd 2J=4.4 Hz, 2J=9.7 Hz, 1H, H2); 1.55 (qd, 3J=4.4 Hz, 2J=9.7 Hz, 2H, H3); 0.89 (m, 1H, H4); 0.62 (d, 3J=6.6 Hz, 3H, H5′); 0.51 (d, 3J=6.4 Hz, 3H, H5)RMN 31P: (162 MHz, CD3DO) delta (ppm): -14.59 (s, 1P)RMN 13C: (100 MHz, CD3DO) delta (ppm): 180.90 (10, C20); 161.59 (1C, C1); 141.42 (1C, C21); 139.32 (1C, C24); 139.13 (10, C23); 138.0 (10, C6); 137.74 (1C, C22); 135.8 (4C, C10,14,15,19) 134.33 (1C, C9); 131.87-129.13 (8C, C7,8,11-13,166-18); 76.94 (1C, C2); 44.54 (10, C4); 25.7 (1C, C5); 24.3 (1C, C5′); 21.9 (1C, C3)

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Patent; Mauduit, Marc; Rix, Diane; Crevisy, Christophe; Wencel, Joanna; US2010/267956; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: All syntheses were carried out in the same fashion. Each reaction was monitored by TLC for 24 h to determine when the starting materials had been consumed. All TLC analyses were run on Selecto Scientific flexible silica gel-coated plates containing a fluorescent indicator and were developed using a hexanes-ethyl acetate (4:1) solution as the eluent. The following procedure is representative of the synthesis of all chalcones (see [Chart 1] and [Chart 2] for structures): A 25-mL round-bottomed flask was charged with the appropriate derivatives of both acetophenone (3 mmol) and benzaldehyde (3 mmol), and mixed with 10 mL of 95percent EtOH. The mixture was then stirred magnetically while being gently heated (in a 30 ¡ãC water bath) until both starting materials dissolved. In a separate flask, NaOH (3.5 mmol) was added to 10-mL of an ethanol-water (1:1) and the mixture was stirred magnetically until the solid dissolved. The NaOH solution was then added dropwise (using a Pasteur pipet) to the ethanolic solution of acetophenone and benzaldehyde described above. In most cases, the reaction mixture turned yellow and solidified within a few minutes. Ice water (2 mL) was added to the flask and the mixture was stirred vigorously. The solid was collected on a Hirsch funnel, washed with cold water, and air-dried overnight. The purity of the crude product was determined at this point using a combination of TLC analysis, melting point measurement, and 1H NMR spectroscopy. In case of an oily product, the reaction mixture was extracted with two 10-mL portions of CH2Cl2 and the organic phase was collected, dried over Na2SO4, and removed using a rotary evaporator. The purity of the oily product was then determined as described above. All impure products (solid or oil) were purified by column chromatography using Merck Silica gel (grade 60, 230-400 mesh) and 4:1 hexanes-ethyl acetate as eluent. In case of a solid, chromatographic separation was followed by recrystallization from either methanol or ethanol-water mixture. In all cases, the purity of the final product was checked again as described above; the spectral characteristics were found to be in good general agreement with those found in the literature.4 The organic chalcones prepared for this study were either pale-yellow solids or oils of the same color (as specified); the ferrocenyl analogs were reddish-orange solids or oils. For each of the reported compounds below, the 1H NMR data is presented as delta (multiplicity, integral ratio), and the IR data as nuCO, nuCC. The following percent yield and physical data are for new chalcones prepared for this study. Data for other chalcones (not given below) have been reported elsewhere[4], [5] and [6] and are also available online as Supplementary data., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Attar, Saeed; O’Brien, Zachary; Alhaddad, Hasan; Golden, Melissa L.; Caldero?n-Urrea, Alejandro; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 2055 – 2073;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate