Chiral phosphine ligands

657408-07-6, Dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,657408-07-6

To an oven-dried 25 mL round bottom flask equipped with a Teflon-coated magnetic stir bar and rubber septum was added 2-dicyclohexylphosphino-2’6’dimethoxybiphenyl (5.13 g, 12.5 mmol) and CH2Cl2 (5 mL). The solution was cooled to 0 C. using an ice/water bath and then concentrated H2SO4 (32.5 mL, 625 mmol) was added dropwise. The solution slowly turned yellow in color. The solution was heated to 40 C. in a preheated oil bath and was allowed stir for 24 h. At this time it was cooled to 0 C. using an ice/water bath and crushed ice (50 g) was added. The solution turned cloudy and white in color. An aqueous solution of NaOH (6.0 M, 200 mL) was then added dropwise to the cooled solution until it became neutral (pH 7.0 as judged by pH paper). The aqueous solution was extracted with CH2Cl2 (3¡Á300 mL) and concentrated under reduced pressure to give a light yellow solid. The crude material was then dissolved in a minimum amount of cold methanol (20 mL), filtered and concentrated (this cycle was repeated) to give sodium 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl-3′-sulfonate (2) as a light yellow solid (6.35 g, 99%). Mp=165 C. (turned red, dec.) 1H NMR (400 MHz, CD3OD) delta: 7.88 (d, 1H, J=8.8 Hz), 7.60 (m, 1H), 7.36 (m, 2H), 7.22 (m, 1H), 6.76 (d, 1H, J=8.8 Hz) 3.70 (s, 3H), 3.39 (s, 3H), 1.14-2.01 (m, 22H). 13C NMR (125 MHz, CD3OD) delta: 161.3, 157.1, 143.3, 142.9, 137.9, 137.8, 133.7, 133.6, 133.3, 133.2, 131.9, 130.0, 129.3, 128.0, 127.9, 127.8, 105.9, 61.6, 56.1, 50.0, 37.0, 36.9, 34.8, 34.6, 31.7, 31.6, 31.5, 31.2, 31.0, 30.8, 30.7, 28.9, 28.8, 28.7, 28.4, 28.34, 28.31, 28.2, 27.8, 27.7. 31P NMR (162 MHz, CD3OD) delta: -8.02. IR (neat, cm-1): 3453, 2925, 2849, 1577, 1462, 1448, 1400, 1229, 1191, 1099, 1053, 736. Anal. Calcd for C26H34NaO5PS: C, 60.92; H, 6.69. Found: C, 60.40; H, 6.85. 1H NMR (d4-MeOH/D2O) is shown in FIG. 7. 31P NMR (d4-MeOH) is shown in FIG. 7.

As the paragraph descriping shows that 657408-07-6 is playing an increasingly important role.

Reference£º
Patent; Massachusetts Institute of Technology; US2006/173186; (2006); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

Compound Re-9 (65mg, 0.12mmol) and tris(4-methoxyphenyl)phosphine (2, 56mg, 0.16mmol) in acetonitrile (anhydrous, 10mL) were added into a flask under a stream of nitrogen. After reflux at 100C overnight and concentrated, the Re-10 (light yellow solid, 38.6mg, 37%) was obtained via a silica gel chromatography (dichloromethane/methane=20/1, v/v). 1H NMR (400MHz, MeOD-d4) delta 7.67-7.62 (m, 6H, CH-Ph), 7.27-7.24 (m, 6H, CH-Ph), 6.21 (t, J=2.28Hz, 2H, CH-Cp), 5.63 (t, J=2.28Hz, 2H, CH-Cp), 3.93 (s, 9H, PhOCH3), 3.23-3.15 (m, 2H, O=C-CH2), 2.67 (t, J=6.84Hz, 2H, CH2-P), 1.73-1.62 (m, 4H, CH2-CH2), 1.59-1.54 (m, 2H, CH2). 31P NMR (400MHz, MeOD-d4) delta 21.38. HRMS (+TOF MS): m/z calculated for C35H35ReO7P+ [M]+ 785.1672, found 785.1676.

855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Li, Xiaoyan; Chen, Shuting; Liu, Zelan; Zhao, Zuoquan; Lu, Jie; Journal of Organometallic Chemistry; vol. 871; (2018); p. 28 – 35;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, General procedure: The following procedure was used in place of the general procedure for this reaction: SiO2 (0.0561 g) and di-(mu-acetato)bis-{2-[(N,N-dimethylamino)methyl]phenyl-C,N}dipalladium(II) 1a (0.0222 g, 0.0370 mmol) were mixed first in a small round-bottomed flask. A stir bar was inserted and the flask, septum, and stirring spatula were all transferred to a glove box with an atmosphere of N2. Benzyldiphenylphosphine 7 (0.020 g, 0.072 mmol) was then added to the flask and thoroughly mixed with the spatula. The reaction was allowed to stir at room temperature in the glove box. The flask was capped with the septum before being removed from the glove box and put in a preheated oil bath (100 C) for 2 h. No CaCl2-filled syringe was used in this reaction. The reaction mixture was filtered into a flask with LiCl as described in the general procedure and purified using preparative TLC in CH2Cl2.

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Lamb, Jessica R.; Stepanova, Valeria A.; Smoliakova, Irina P.; Polyhedron; vol. 53; (2013); p. 202 – 207;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

15929-43-8, Bis(4-(trifluoromethyl)phenyl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

169 mg (0.5 mmol) of bis(4-trifluoromethylphenyl)phosphorus,115.5 mg (0.75 mmol) of 4,4-dimethoxy-2,5-cyclohexadien-1-one,0.05 mmol of water and 1.0 mL of toluene were placed in a Schlenk tube under nitrogen, and the reaction was stirred at 100 C for 12 hours. After completion of the reaction, it was purified by column chromatography, and the isolated yield was 69%., 15929-43-8

15929-43-8 Bis(4-(trifluoromethyl)phenyl)phosphine oxide 12022239, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Hunan Institute of Science and Technology; Xiong Biquan; Wang Gang; Tang Kewen; Xu Weifeng; (8 pag.)CN109096331; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Example 4 15 g of 2-chlorobenzonitrile, 14.8 g of p-tolueneboronic acid and 28.9 g of sodium carbonate together with 50 ml of p-xylene, 40 ml of DMSO and 10 ml of water are heated to 120 C. At 80 C., a mixture of 24.7 g of palladium acetate and 0.55 ml of 0.6 M aqueous TPPTS solution in 2.5 ml of DMSO is added. After the reaction is complete, the phases are separated. The aqueous phase is washed with 50 ml of xylene. The combined organic phases are washed with 20 ml of water and dried over sodium sulfate. The solvent is evaporated and the residue is crystallized from n-heptane. This gives 18.6 g (88%) of 4′-methylbiphenyl-2-carbonitrile having a melting point of 48-49 C.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Clariant GmbH; US2001/20104; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Several ml of toluene were condensed into evacuated ampoule containing the mixture of 5mg (1 eq) of (CO)2Rh(SQ) and 1.1 eq of corresponding diphos under intensive cooling by liquid N2. Solution was quickly brought to room temperature with shaking and placed into EPR cavity immediately. All of reactions were carried out without isolation of the products.

13991-08-7, As the paragraph descriping shows that 13991-08-7 is playing an increasingly important role.

Reference£º
Article; Kozhanov; Bubnov; Teplova; Abakumov; Cherkasov; Journal of Molecular Structure; vol. 1147; (2017); p. 541 – 548;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787618-22-8,Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

787618-22-8, General procedure: Representative procedure for the preparation of rPdtoptionally substituted (Ri?), allyl)(liqand)(X) complexes: A dry Schlenk tube is charged with the ligand (4.74 mmol) and [(optionally substituted (Ri2)m- allyl)PdCI]2 (2.36 mmol). The tube is evacuated and backfilled with nitrogen a total of three times. 10 mL of anhydrous solvent (such as THF or toluene) is added and the mixture is stirred at room temperature for a period of time (e.g . 20 minutes). Pentane (5 mL) or hexanes is added to fully precipitate the product. The product is collected by vacuum filtration, washed (3 x 10 mL of pentane, or hexanes) and dried under vacuum

The synthetic route of 787618-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, Example 13B tert-butyl (1S)-2-({6-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)-1-(1H-indol-3-ylmethyl)ethylcarbamate A solution Example 13A (1.50 g, 3.125 mmol), Pd2(dba)3 (71 mg, 0.078 mmol) and tri-o-tolylphosphine (71 mg, 0.23 mmol) in DMF (30 mL) was treated with 4-vinylpyridine (492 mg, 4.68 mmol) and triethylamine (1.30 mL, 9.4 mmol), purged with nitrogen, and heated to 100 C. for 4 hours. The mixture was cooled to room temperature, treated with ethyl acetate (200 mL), washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 75% ethyl acetate/hexanes to provide the desired product (1.37 g, 87%). MS (APCI) m/e 505, 507 (M+H)+.

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert; Dinges, Jurgen; Hutchins, Charles; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.; US2003/187026; (2003); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1160861-53-9,Di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A 250-mL round-bottomed flask equipped with a stirbar was charged with 2-aminobiphenylpalladium chloride dimer (3.41 g, 5.5 mmol, 0.50 eq) and silver triflate (2.82 g, 11 mmol, 1.00 eq.) and shielded from light. Then dichloromethane (100 mL) was added and the mixture was stirred at room temperature for 30 min. The suspension was then filtered through a wet pad of Celite into a 500-mL round-bottomed flask equipped with a stir bar containing tBuBrettPhos (5.33 g, 11 mmol, 1.00 eq). An additional portion of dichloromethane (50 mL) was used to rinse the first flask and elute the mixture through the Celite plug. The resulting mixture was stirred at room temperature for 2 h, until becoming deep red in color. After removing 90% of the solvent via rotary evaporation, pentane (200 mL) was added to precipitate the precatalyst. The suspension was sonicated for 30 minutes, crushed with a spatula and filtered. The resulting solid was dried under vacuum overnight to give the title compound as a dark orange solid. Yield: 9.59 g, 96%. FIG. 9.

1160861-53-9, The synthetic route of 1160861-53-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Massachusetts Institute of Technology; Bruno, Nicholas C.; Buchwald, Stephen L.; US2013/331566; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 1-phenylpropyne (0.058 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI (0.019 g, 0.1 mmol), phenyl isopropyl hydroperoxide(0.31 g, 2 mmol) and acetonitrile (2 mL),50oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 91%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate