Catalytic asymmetric cyclocarbonylation of o-isopropenylphenols: Enantioselective synthesis of six-membered ring lactones was written by Dong, Chune;Alper, Howard. And the article was included in Journal of Organic Chemistry in 2004.Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) This article mentions the following:
Cyclocarbonylation of o-isopropenylphenols with CO and H2, using Pd(OAc)2 and (+)-DIOP as the chiral catalyst, in CH2Cl2 afforded 3,4-dihydro-4-methylcoumarins, e.g., I, in good yields and enantiomeric excess. The stereoselectivity was influenced by the structure of the chiral phosphine ligands and substrates, as well as by the reaction conditions. In the experiment, the researchers used many compounds, for example, (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)).
(((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine) (cas: 37002-48-5) belongs to chiral phosphine ligands. Thousands of arylphosphines have been used as chiral ligands for metal-catalyzed asymmetric reactions. Most of these phosphines are acyclic, usually possess low nucleophilic activity, and generally display poor enantioselectivities for phosphine organocatalysis. Name: (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)
Referemce:
Phosphine ligand,
Chiral phosphines in nucleophilic organocatalysis