Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical & Pharmaceutical Bulletin called Synthesis and pharmacological evaluation of 3-[(4-oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives as orally active AMPA receptor antagonists, Author is Inami, Hiroshi; Shishikura, Jun-ichi; Yasunaga, Tomoyuki; Hirano, Masaaki; Kimura, Takenori; Yamashita, Hiroshi; Ohno, Kazushige; Sakamoto, Shuichi, which mentions a compound: 49609-84-9, SMILESS is O=C(Cl)C1=CC=CN=C1Cl, Molecular C6H3Cl2NO, Computed Properties of C6H3Cl2NO.
3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives I [R = 4-Me, 4-F, 4-Br, etc.] were synthesized and administered them to mice to evaluate their anticonvulsant activity in maximal electroshock (MES)- and pentylenetetrazol (PTZ)-induced seizure tests, and their effects on motor coordination in a rotarod test. compounds I [R = 4-trifluoromethoxy, 2,2-difluoro-2H-1,3-benzodioxol-5-yl] exhibited potent anticonvulsant activity in both seizure tests and induced minor motor disturbances as indicated in the rotarod test. The protective index values of I [R = 4-trifluoromethoxy, 2,2-difluoro-2H-1,3-benzodioxol-5-yl] for MES-induced seizures (10.7 and 12.0, resp.) and PTZ-induced seizures (6.0 and 5.6, resp.) were considerably higher compared with those of YM928 and talampanel.
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Reference:
Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate