Electric Literature of 1608-26-0. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1608-26-0, Name is Tris(dimethylamino)phosphine
Hydrolysis of 2?,3?-O-methyleneadenosin-5?-yl 5?-O-methyluridin-2?-yl 5?-O-methyl-2?- trifluoroacetamido-2?-deoxyuridin-3?-yl phosphate (1b) has been followed by HPLC over a wide pH range to study the effects of potential hydrogen bonding interactions of the 2?-trifluoroacetamido function on the rate and product distribution of the reaction. At pH < 2, decomposition of 1b (and its 3?,3?,5?-isomer 1a) is first-order in hydronium-ion concentration and cleavage of the P-O3? bond of the 2?- trifluoroacetamido-modified nucleoside is slightly favored over cleavage of the P-O5? bond. Between pH 2 and 4, the overall hydrolysis is pH-independent and the P-O3? and P-O5? bonds are cleaved at comparable rates. At pH 5, the reaction becomes first-order in hydroxide-ion concentration, with P-O3? bond cleavage predominating. At 10 mmol L-1 aqueous sodium hydroxide, no P-O5? bond cleavage is observed. Compared to the 2?-OH counterpart 2, a modest rate enhancement is observed over the entire pH range studied. The absence of P-O5? fission under alkaline conditions suggests hydrogen bond stabilization of the departing 3?-oxyanion by the neighboring 2?-trifluoroacetamido function. If you are hungry for even more, make sure to check my other article about 1608-26-0. Electric Literature of 1608-26-0
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Phosphine ligand,
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate