7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
7650-91-1, 1. “A”reaction. Benzyldiphenylphosphine (approximately 2.0 g or 13 mmol from Strem Chemicals, Inc. of Newburyport, Massachusetts (“Strem”) ) and platinum (II) chloride (approximately 1.8 g or 12 mmol ; Strem) can be combined in the presence of tetrabutylammonium chloride (approximately 330 mg or 0.12 mmol from Sigma-Aldrich Corp. of St. Louis, Missouri (“Aldrich”)) in chlorobenzene (approximately 100 mL; ALDRICH) and can be stirred at approximately 130 C for approximately 10 minutes under nitrogen, after which time the volatile components can be removed in vacuo. The solid residue may be suspended in methanol, and the resulting solid can be isolated via filtration, washed with ether, and allowed to dry in vacuo. The yield of this resulting solid can be approximately 3.5 g. 2. “B”reaction. The entire yield of the resulting solid from the A reaction can be combined with 2,2, 6,[6-TETRAMETHYL-3, 5-HEPTANEDIONE, sodium salt (approximately 1.8 g or 8.7 mmol that can be prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2- ethoxyethanol (approximately 50 mL; ALDRICH). The contents may be stirred under nitrogen at approximately 120 C for approximately 45 minutes. The volatile components can then be removed in vacuo. The desired product can be purified from a resulting crude dark brown solid via silica gel flash chromatography with hexanes/ethyl acetate (at a ratio of approximately 20: 1) as the eluting solvent (product Rf = 0.7). The desired product (approximately 250 mg or 0.38 mmol, 3.2% from PtCI2) can be isolated as a colorless foamy solid that exhibits blue luminescence under 254 and 365 nm illumination. 1H NMR (300 MHz, CD2CI2, 296 K): 7.76-7. 83 (4H, m), 7.38-7. 46 (4H, m), 7.13-7. 25 (2H, m), 6.90-7. 13 (3H, m), 5.86 (1H, s), 3.71 (2H, d, J = 11.6 Hz), 1.29 (9H, s), 1.09 (9H, s) ppm.
As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.
Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate