Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78%).2

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Weigh 0.2 mmol of (E)-1,3-diphenylpropene, 0.3 mmol of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone into a 15 mL pressure-resistant reaction tube and add magnetic stirring. The mixture was reacted with 2 mL of nitromethane at room temperature for 5 min, monitored by TLC, and then reacted with 0.4 mmol of bis(naphthalen-1-yl)phosphine oxide for 6 h. After completion of the reaction, it was extracted with 20 ml of sodium sulfite solution, 10 mL of ethyl acetate, dried over anhydrous sodium sulfate at 20 C for 10 minutes and filtered, and finally distilled under reduced pressure at -0.09 MPa at 40 C to remove organics. The product (E)-(1,3-diphenylallyl)bis(naphthalen-1-yl)phosphine oxide was obtained as a solvent in a yield of 96%., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Guangdong University of Technology; Wen Chunxiao; Chen Qian; Wang Xiaofeng; Yu Guodian; Huo Yanping; Zhang Kun; (15 pag.)CN108774263; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Under nitrogen, a mixture of 1 (115 mg, 0.138 mmol) and ethyl diphenylphosphinite (600 muL, 2.78 mmol) in a 25 mL flask was heated for 30 min at 100 C. Toluene (2 mL) was then added and the mixture was heated at reflux for 2 h. The product mixture was purified by column chromatography (silica gel) using a non-polar eluent (EtOAc/CH2Cl2, 1:1) to remove by-products and then a polar mixture (EtOAc/MeOH, 9:1) to separate the product. The eluate was concentrated and dried under vacuum to give a white solid foam 2 (175 mg, 95%).1HNMR (400 MHz, CDCl3) delta 7.71-7.66 (m, 12H, Ar-H), 7.50-7.39 (m, 18H, Ar-H),7.04 (dd, 3JHH=7.9 Hz, 4JHP=1.7 Hz, 6H, Ar-H), 6.97 (d, 3JHH = 7.9 Hz, 6H, Ar-H), 4.08 (q, J = 7.1 Hz, 6H, -COCH2CH3),3.65 (d, 2JHP =13.7 Hz, 6H, CH2P(O)Ph2),3.18 (d, J = 15.7 Hz, 6H, ArCHaHb), 2.95 (s,6H, ArCH2-), 2.80 (d, J = 15.7 Hz, 6H, ArCHaHb), 1.18 (t, J = 7.1 Hz, 9H, -COCH2CH3); 13C NMR (100MHz, CDCl3) delta 176.5 (s, -C=O), 136.8 (d, 5JCP = 2.6 Hz, Ar-C), 135.8 (s, Ar-C), 132.6 (d, 1JCP= 97.6 Hz, Ar-C), 132.2 (d, 4JCP = 2.4 Hz, Ar-C), 131.6 (d, 3JCP = 9.2 Hz, Ar-C), 130.4 (d, 3JCP = 4.8 Hz, Ar-C), 130.1 (d, 4JCP = 2.4 Hz, Ar-C), 129.9 (d, 2JCP = 8.0 Hz, Ar-C), 128.9 (d, 2JCP = 11.6 Hz, Ar-C), 61.1, 56.1, 43.7, 40.3, 38.1 (d, 1JCP = 66.2 Hz, CH2P(O)Ph2), 14.1;31P NMR (162 MHz, CDCl3) delta 31.2; HRMS-FAB (NOBA) Calcdfor C84H82O9P3 (M+H+): m/z (rel intensity) 1330.5272 (12.1%),1330.5248 (1.7%), 1329.5239 (40.8%), 1329.5214 (1.8%), 1328.5205 (90.9%),1327.5172 (100.0%),Observed: m/z (relintensity) 1330.5010 (M+4, 16), 1329.5145 (M+3, 44), 1328.5295 (M+2,90),1327.5162 (M+H+, 100), 1277.3716 (11), Elemental analysis: Calcd forC84H81O9P3: C, 76.00; H, 6.15; O,10.85; P, 7.00, Observed: C, 75.78; H, 6.20.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lim, Dong Seob; Sahoo, Suban K.; Cho, Chan Sik; Kim, Yang; Choi, Heung-Jin; Tetrahedron Letters; vol. 56; 41; (2015); p. 5665 – 5669;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: NMR titration experiments of the guests HPCy3+, N-tosyldiallylamine (7) and Cy3P=O withsulfocalixarenes 1 as hosts: The titration experiments were performed at least in duplicate using a standard?constant guest? method in 600-640 muL D2O with addition of 7-10 muL MeOD-d4 or 10 muL DMSO-d6as internal standard (deltaH (MeOD-d4) = 3.31 ppm; deltaH (DMSO-d6) = 2.50 ppm) at room temperature. AllH-atoms of the guests HPCy3+, N-tosyldiallylamine (7) and Cy3P=O were evaluated using MestRe-C [32]and MestReNova [33]. Kass and log K values of the receptors were obtained by analysising the course ofthe chemical shifts of the protons of the guest HPCy3+, N-tosyldiallylamine (7) and Cy3P=O using theprogram HypNMR2008 [34,35].

13689-19-5, As the paragraph descriping shows that 13689-19-5 is playing an increasingly important role.

Reference£º
Article; Tomasek, Jasmine; Sessler, Miriam; Groeger, Harald; Schatz, Juergen; Molecules; vol. 20; 10; (2015); p. 19130 – 19141;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 1000 ml by adding reaction bottle 95.2g (0.44mol) diphenylmethoxyphosphine and 77g (0.45mol) m-methoxybenzyl chloride making between, to elevate temperature under stirring condition 60 C, and in this temperature 12 hours, cooling to the end of the 20 C, directly enters the reaction of the next., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Chenghe Pharmaceutical & Chemical Co., Ltd.; Xia, Qiujing; (6 pag.)CN105541569; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

As the paragraph descriping shows that 6372-42-5 is playing an increasingly important role.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

The compound was synthesized with some minor changes to the published procedure [37]. Thus, freshly distilled tris(dimethy-lamino) phosphine (11.1 g, 0.068 mol) was placed in a round bottom flask equipped with thermometer, flushed with argon and 1-bromohexane (10.0 mL, 0.071 mol) was added dropwise at r.t. with gentle stirring. The stirring was continued at 25 C for 13 h, whereupon the reaction mixture was slowly heated to 105 C, at which temperature an exothermic effect was evident. External heating was then discontinued and the reaction temperature was maintained at 105 C for 30 min by air-cooling (Caution: the reaction is very exothermic and the sharp temperature jump ispossible, thus requiring constant temperature monitoring). Finally heating was resumed and stirring was continued for 15 min at110 C. Upon cooling to r.t. the reaction mass solidified. Unreacted reagents were partially removed by heating to 80 C/10-12 mm Hg for 2 hours. The obtained solid mass was consequently washed with anhydrous ethyl acetate and hexane. After evaporation of residual solvents at 60 C/10-12 mm Hg, the product was dissolved in anhydrous dichloromethane and boiled with charcoal. The charcoal was then filtered off and dichloromethane was stripped off under reduced pressure at 30 C. The product was obtained as white crystalline solid, which was finally dried at 60 C/1 mm Hg for 5 h (hereinafter with a special flask filled with P2O5 and introduced into the vacuum line). Yield: 14.5 g (66%); mp = 67-68 C; 1H NMR (400 MHz, CDCl3): 2.86-2.84 (d, 18H, CNE=3), 2.60-2.56 (m, 2=, CE=2), 1.61-1.51 (m, 4=, E=2E=2(E=2)2E=3), 1.33-1.30 (m, 4=, E=2E=2E=3), 0.91-0.87 (m, 3=, E=2E=3); IR (KBrpellet): 3006 (w, nE-=), 2929 (s, nE-=), 2856 (s, nE-=), 2816 (m,nE-=), 2732 (w, nE-=), 1488 (m), 1468 (w), 1306 (s), 1262 (w), 1169(m), 1071 (m), 998 (vs, nP-N), 962 (vs, nP-N), 812 (m), 791 (m), 737(w), 622 (w) cm1., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Shaplov, Alexander S.; Lozinskaya, Elena I.; Vlasov, Petr S.; Morozova, Sofia M.; Antonov, Dmitrii Y.; Aubert, Pierre-Henri; Armand, Michel; Vygodskii, Yakov S.; Electrochimica Acta; vol. 175; (2015); p. 254 – 260;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

To a stirred solution of CsF (63 mg, 0.42 mmol) in anhydrous acetonitrile 1 mL was consecutively added 2,5 dimethyl-(o-trimethyl silyl)phenyl triflate (25 mg, 0.077 mmol) and ethoxydiphenylphosphine (60 mg, 0.31 mmol). Reaction mixture was allowed to stir at room temperature (30 C.) for 30 hrs. The reaction mixture was concentrated and directly loaded on silica gel column and purified by using solvent gradient of Pet. Ether: Ethyl Acetate (1:1) to yield a white solid phosphine oxide (19 mg, 81%). Reaction Time: 30 h; Rf: 0.3 (1:1 EtOAc:Pet Ether); White Solid; mp 157-159 C.; 19.0 mg, 81%; 1H NMR (400 MHz, CDCl3, TMS) delta 7.75-7.60 (m, 4H), 7.59-7.52 (m, 2H), 7.51-7.43 (m, 4H), 7.26-7.20 (m, 1H), 7.19-7.13 (m, 1H), 6.88 (d, J=14.4 Hz, 1H), 2.37 (s, 3H), 2.21 (s, 3H); 13C NMR (100 MHz, CDCl3, TMS) delta 140.0 (d, J=7.7 Hz), 134.7 (d, J=13.1 Hz), 133.9 (d, J=12.3 Hz), 132.9 (d, J=103.3 Hz), 132.8 (d, J=2.3 Hz), 131.9 (d, J=10.0 Hz), 131.8, 131.7 (d, J=3.1 Hz), 130.4 (d, J=103.3 Hz), 128.5 (d, J=11.6 Hz), 21.2 (d, J=4.6 Hz), 21.0; 31P NMR (162 MHz, CDCl3) delta 31.7; HRMS-ESI (m/z) calcd (C20H19OP+H)+: 307.1246 found: 307.1244

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Mhaske, Santosh Baburao; Dhokale, Ranjeet Ashokrao; US2015/210725; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgOTf (0.0513 g, 0.2 mmol) into the reaction flask. After stirring for 18 h and then filtrating, the filtrate was slow evaporated at ambient temperature. 8 days later, colorless block-shaped crystals were obtained. Yield: 39.2percent (0.0935 g). Anal. Calc. for(C63H52AgF3O4P4S): C, 63.38; H, 4.36; N, 0. Found: C, 63.26; H,4.32; N, 0percent. IR (cm-1, KBr pellets): 3467br, 3055m, 1968w,1660m, 1587m, 1564m, 1482s, 1461s, 1435vs, 1280vs, 1253vs,1223s, 1160s, 1097s, 1069m, 1029vs, 999m, 877w, 798m, 746s,724m, 694vs, 636s, 572w, 512s, 473m, 448w, 421w. 1H NMR(600 MHz, CDCl3): 2.90 (d, 4H, dppe), 6.66?7.28 (m, 48H, Ph). 31P{1H} NMR (243 MHz, CD3Cl): 5.1 (br, d, JAg?P = 364.5 Hz, dppe),5.3 (dt, J19F?P = 211.4 Hz, dppe), 10.1 (2d, J19F?P = 102.1 Hz, DPEphos),11.3 (2d, J19F?P = 116.7 Hz, DPEphos), 11.5 (dd, J109Ag?P = 245.4 Hz,J107Ag?P = 235.7 Hz, DPEphos)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

cis-RuC12(slMes)(t-butylvinylidene)(Ph2P(OMe)), cis-C777v: trans-C 71 9v (5.0 g, 7.0 mmol) was placed in a round-bottomed flask with a magnetic stir bar under nitrogen, to which degassed CH2C12 was added (40 mL). Phosphinite Ph2P(OMe) (2.26 g, 10.5 mmol) was added via syringe. The reaction vessel was evacuated and refilled with N2 (3x). The reaction was stirred under N2 for 60 mm at ambient temperature (20 – 25 C) yielding a yellow crystalline solid. The crude material was filtered, washed with heptanes and dried under high vacuum to provide a crude yellow solid (3.6 g). The crude yellow solid (1.6 g) was dissolved in degassed CH2C12 (2000 mL) and filtered through Celite. The filtrate was concentrated under high vacuum and the resulting solid was recrystallized in CH2C12/heptanes. The crystals were filtered and washed with heptanes and dried under high vacuum to yield a yellow solid. Yield: 1.3g. ?H NMR (400 IVIHz, CD2C12, ppm): oe 7.46 -7.41 (m, 1H), 7.39- 7.28 (m, 5H), 7.18 – 7.14 (m, 3H), 7.000 (s, 1H), 6.95 (s, 1H), 6.90 – 6.85 (m, 2H), 6.64 (s, 1H), 4.06 – 3.85 (m, 4H), 3.35 (d, J= 11 Hz, 3H), 2.80 (s, 3H), 2.77 (s, 3H) 2.40 (s, 6H), 2.33 (s, 3H), 2.09 (s, 3H), 1.93 (d, J= 5 Hz, 1H), 0.33 (s, 9H). 3?P NIVIR (161.8 IVIHz, C6D6, ppm): oe 135.15 (s)., 4020-99-9

The synthetic route of 4020-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MATERIA, INC.; GIARDELLO, Michael, A.; TRIMMER, Mark, S.; WANG, Li-Sheng; DUFFY, Noah, H.; JOHNS, Adam, M.; RODAK, Nicholas, J.; FIAMENGO, Bryan, A.; PHILLIPS, John, H.; (127 pag.)WO2017/53690; (2017); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate